| PUBLICATIONS (Ranked by impact factor of the journal) | The Critical Role of ECM Proteins within the Human MSC Niche in Endothelial Differentiation Scientists found that fetal pre-osteoblast and adult trabecular bone-derived mesenchymal stem cells (MSCs) express similar surface markers as bone marrow MSCs and can differentiate into adipocytes, osteoblasts, and chondrocytes. However, when cultured in extracellular matrix (ECM) and endothelial differentiation conditions, bone-derived MSCs more readily form tubular structures and uptake acetylated low-density lipoproteins, fulfilling the functional criteria for endothelial cells. [Biomaterials] Abstract A MicroRNA-30e/Mitochondrial Uncoupling Protein 2 Axis Mediates TGF-β1-Induced Tubular Epithelial Cell Extracellular Matrix Production and Kidney Fibrosis Investigators found that mitochondrial uncoupling protein 2 (UCP2) was induced in kidney tubular epithelial cells after unilateral ureteral obstruction in mice and that mice with ablated UCP2 resisted obstruction-induced kidney fibrosis. [Kidney Int] Full Article The Downregulation of MicroRNA let-7a Contributes to the Excessive Expression of Type I Collagen in Systemic and Localized Scleroderma Systemic and localized scleroderma is characterized by excessive deposition of collagen and tissue fibrosis in the skin. Although they have fundamental common characteristics including autoimmunity, little is known about the exact mechanism that mediates the excessive collagen expression in these disorders. The authors evaluated the possibility that microRNAs play some roles in the pathogenesis of fibrosis seen in these diseases. [J Immunol] Abstract An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation in Response to Candida albicans Researchers report that recognition of purified fungal pathogen-associated molecular pattern β-glucan by human neutrophils causes rapid homotypic aggregation and neutrophil extracellular trap release by a mechanism that requires fibronectin. [J Immunol] Abstract Construction and In Vivo Evaluation of a Dual Layered Collagenous Scaffold with a Radial Pore Structure for Repair of the Diaphragm To mimic the structure of the diaphragm, dual layered collagenous scaffolds were constructed with a radial pore orientation, prepared by inward out freezing, and reinforced by a layer of compressed collagen. Similar scaffolds with a random round pore structure were taken as controls. [Acta Biomater] Abstract The Proteoglycan Trol Controls the Architecture of the Extracellular Matrix and Balances Proliferation and Differentiation of Blood Progenitors in the Drosophila Lymph Gland The pattern of basement membranes, reported by Terribly Reduced Optic Lobes (Trol) expression, is spatio-temporally correlated to hematopoiesis. The central, medullary zone which contain undifferentiated hematopoietic progenitors has many, closely spaced membranes. Loss of trol causes a dramatic change of the extracellular matrix into a three-dimensional, spongy mass that fills wide spaces scattered throughout the lymph gland. [Dev Biol] Abstract The Extracellular Matrix Regulates MaeuCath1a Gene Expression Researchers investigated the extracellular matrix (ECM) for its regulatory role in MaeuCath1 gene expression. Reverse transcription qPCR using RNA isolated from mammary epithelial cells cultured on ECM showed that ECM regulates MaeuCath1a gene expression in a lactation phase-dependent manner. [Dev Comp Immunol] Abstract Influence of Extracellular Matrix Proteins and Substratum Topography on Corneal Epithelial Cell Alignment and Migration Scientists investigated the influence of the combination of exogenous coating of extracellular matrix proteins with substratum topography on cytoskeletal architecture as well as alignment and migration of immortalized corneal epithelial cells. [Tissue Eng Part A] Abstract |
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