The Extracellular Matrix Component Psl Provides Fast-Acting Antibiotic Defense in Pseudomonas aeruginosa Biofilms Using a combination of static and continuous-flow biofilm experiments scientists showed that Psl, one major polysaccharide in the Pseudomonas aeruginosa biofilm matrix, provides a generic first line of defense toward antibiotics with diverse biochemical properties during the initial stages of biofilm development. [PLoS Pathog] Full Article Procollagen III N-Terminal Propeptide and Desmosine Are Released by Matrix Destruction in Pulmonary Tuberculosis Researchers investigated the hypothesis that matrix metalloproteinases activity generates matrix turnover products as correlates of lung pathology. [J Infect Dis] Abstract | Press Release The EDA-Containing Cellular Fibronectin Induces Epithelial Mesenchymal Transition in Lung Cancer Cells through Integrin α9β1-Mediated Activation of PI3-K /Akt and Erk1/2 The authors found that cellular fibronectin, but not plasma fibronectin or type 1 collagen, induces lung carcinoma cell scattering in vitro, promotes cell migration and invasion of Matrigel, and stimulates the expression of the mesenchymal marker α-smooth muscle actin, while decreasing the expression of the epithelial marker E-cadherin through PI3-K and Erk pathways. [Carcinogenesis] Abstract The Importance of Size-Exclusion Characteristics of Type I Collagen in Bonding to Dentin Matrices Investigators studied the size-exclusion characteristics of dentin collagen, using a gel-filtration-like column chromatography technique, using dentin powder instead of Sephadex. [Acta Biomater] Abstract Role of Collagen Matrix in Tumor Angiogenesis and Glioblastoma Multiforme Progression Scientists showed that physical compaction (the process in which cells gather and pack together and cause associated changes in cell shape and size) of human glioblastoma cell lines U87MG, U251, and LN229 induces expression of collagen types IV and VI and the collagen crosslinking enzyme lysyl oxidase and up-regulates in vitro expression of the angiogenic factor vascular endothelial growth factor. [Am J Pathol] Abstract In Vitro Evaluation of Plant-Derived Agents to Preserve Dentin Collagen Scientists investigated the effect of various plant-derived agents (hesperidin, proanthocyanidin, epigallocatechin gallate and genipin) on the stability of dentin collagen matrix to resist collagenase degradation. [Dent Mater] Abstract Microrheological Characterization of Collagen Systems: From Molecular Solutions to Fibrillar Gels Using optical-tweezers-based microrheology, researchers investigated mechanical properties both of collagen molecules at a range of concentrations in acidic solution where fibrils cannot form and of gels of collagen fibrils formed at neutral pH, as well as the development of microscale mechanical heterogeneity during the self-assembly process. [PLoS One] Full Article Mesenchymal Stem Cells Exploit Extracellular Matrix as Mechanotransducer Investigators showed that human mesenchymal stem cells harvest and assemble plasma fibronectin into their extracellular matrix fibrils within 24 hours. [Sci Rep] Full Article |