Three-Dimensional Aspects of Matrix Assembly by Cells in the Developing Cornea Investigators showed that corneal keratocytes occupy a significantly greater tissue volume than was previously thought, and there is a clear orthogonality in cell and matrix organization, quantifiable by Fourier analysis. [Proc Natl Acad Sci USA] Abstract Engineering Cell Matrix Interactions in Assembled Polyelectrolyte Fiber Hydrogels for Mesenchymal Stem Cell Chondrogenesis Scientists demonstrated the significance of oriented ligand presentation for mesenchymal stem cell (MSC) chondrogenesis, and the importance of facilitating an orderly sequence of differentiation events, initiated by proximal interactions between MSCs and the extracellular matrix for robust neocartilage formation. [Biomaterials] Abstract Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage-Specific Fragmentation and Differential Cleavage of COMP Researchers investigated the proteomic composition of injured tendons during early and late disease stages to identify disease-specific cleavage patterns of the extracellular matrix protein Cartilage oligomeric matrix protein (COMP). [J Biol Chem] Abstract | Full Article SMAD4 Mutations Causing Myhre Syndrome Result in Disorganization of Extracellular Matrix Improved by losartan Scientists showed that losartan normalizes metalloproteinase and related inhibitor transcript levels and corrects the extracellular matrix deposition defect in fibroblasts from Myhre syndrome patients. [Eur J Hum Genet] Abstract Influence of Extracellular Matrix Temporal Deposition on the Swelling and Mechanical Properties of TE Cartilage Using a computational approach, researchers aimed to quantify possible effects of temporal variations in the deposition of glycosaminoglycan at given collagen synthesis rates on the mechanical stiffness of cartilage tissue engineered (TE) constructs. [Tissue Eng Part A] Abstract Expression of Modulators of Extracellular Matrix Structure after Anterior Cruciate Ligament Injury The authors quantified the expression of genes for collagen I and III, decorin, tenascin-C, and alpha smooth muscle actin, as well as matrix metalloproteinase-1 and -13 gene expression within multiple tissues of the knee joint after anterior cruciate ligament injury in a large animal model over a 2-week post injury period. [Wound Repair Regen] Abstract PI3K/Akt1 Signaling Specifies Foregut Precursors by Generating Regionalized Extra-Cellular Matrix The authors found that PI3K signaling promotes the transition from naïve endoderm precursors into committed anterior endoderm. PI3K promoted commitment via an atypical activity that delimited epithelial-to-mesenchymal transition. Akt1 transduced this activity via modifications to the extracellular matrix (ECM) and appropriate ECM could itself induce anterior endodermal identity in the absence of PI3K signaling. [eLife] Full Article | Press Release |