Differential Expression of Extracellular Matrix and Growth Factors by Embryoid Bodies in Hydrodynamic and Static Cultures The differences between static and hydrodynamic culture conditions on the expression of extracellular matrix and growth factor molecules during the differentiation of mouse embryonic stem cells were examined at both the gene and protein level. [Tissue Eng] Abstract Enhanced Differentiation of Human Embryonic Stem Cells on ECM-Containing Osteomimetic Scaffolds for Bone Tissue Engineering Scientists investigated the development of a scaffold with native bone extracellular matrix (ECM) components for directing the osteogenic differentiation of human embryonic stem cells. A microsphere-sintering technique was used to fabricate poly(lactic-co-glycolic acid) scaffolds with optimum mechanical and structural properties. [Tissue Eng] Abstract Interleukin-1β Attenuates Myofibroblast Formation and Extracellular Matrix Production in Dermal and Lung Fibroblasts Exposed to Transforming Growth Factor-β1 Using lung and dermal fibroblasts, the authors investigated the effects of interleukin (IL)1β, transforming growth factor-β1 (TGFβ1), and IL1β in combination with TGFβ1 on myofibroblast formation, collagen synthesis and collagen modification (including prolyl hydroxylase, lysyl hydroxylase and lysyl oxidase), and matrix metalloproteinases. [PLoS One] Full Article A Photoactivatable Nanopatterned Substrate for Analyzing Collective Cell Migration with Precisely Tuned Cell-Extracellular Matrix Ligand Interactions Researchers developed a method for analyzing collective cell migration by precisely tuning the interactions between cells and extracellular matrix ligands. [PLoS One] Full Article Cell-Scaffold Interaction within Engineered Tissue A novel gelatin-chitosan scaffold with a unique structure produced by three-dimensional printing technology combining with vacuum freeze-drying has been developed for tissue-engineering applications. [Exp Cell Res] Abstract Soluble Factors Derived from Human Amniotic Epithelial Cells Suppress Collagen Production in Human Hepatic Stellate Cells Scientists investigated whether factors secreted by human amniotic epithelial cells (hAECs) and present in hAEC-conditioned medium have anti-fibrotic effects on activated human hepatic stellate cells. [Cytotherapy] Abstract The Membrane-Targeted Alkylphosphocholine Erufosine Interferes with Survival Signals from the Extracellular Matrix Researchers aimed to understand whether and how the paradigmatic membrane-targeted synthetic phospholipid analog erufosine is relevant for tumor cell adhesion to extracellular matrix proteins, cell survival and migration. [Anti-Cancer Agents Med Chem] Abstract Type III Collagen Regulates Osteoblastogenesis and the Quantity of Trabecular Bone Research findings indicate that Type III collagen plays a role in development of trabecular bone through its effects on osteoblast differentiation. [Calcif Tissue Int] Abstract |