Extracellular Matrix News Volume 5.23 | Jun 19 2014

The Influence of Extracellular Matrix Composition on the Differentiation of Neuronal Subtypes in Tissue Engineered Innervated Intestinal Smooth Muscle Sheets
Researchers describe the formation of tissue engineered innervated sheets, where intestinal smooth muscle and enteric neuronal progenitor cells are brought into close association in extracellular matrix based microenvironments. [Biomaterials] Abstract

Tranilast, an Orally Active Antiallergic Compound, Inhibits Extracellular Matrix Production in Human Uterine Leiomyoma and Myometrial Cells
Scientists aimed to determine the effect of tranilast (an antiallergic drug known to suppress fibrosis or to stabilize mast cells) on extracellular matrix production in human leiomyoma and myometrial cells. [Fertil Steril] Abstract

A Biocomposite of Collagen Nanofibers and Nanohydroxyapatite for Bone Regeneration
Researchers designed a synthetic construct that mimics the natural bone extracellular matrix through innovative approaches based on simultaneous type I collagen electrospinning and nanophased hydroxyapatite electrospraying using non-denaturating conditions and non-toxic reagents. [Biofabrication] Abstract

Osteoarthritic Cartilage Explants Affect Extracellular Matrix Production and Composition in Cocultured Bone Marrow-Derived Mesenchymal Stem Cells and Articular Chondrocytes
Investigators established a novel in vitro coculture model to evaluate the influence of osteoarthritic (OA) cartilage explants on composition of newly produced matrix and chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells and the phenotype of OA chondrocytes. [Stem Cell Res Ther]
Abstract | Full Article

Morphofunctional Characterization of Decellularized Vena Cava as Tissue Engineering Scaffolds
The authors evaluated different chemical induced decellularization protocols of the inferior vena cava of rabbits. They assessed the remaining extracellular matrix integrity, residual toxicity and the biomechanical resistance of the scaffolds. [Exp Cell Res] Abstract

Over-Expression of Laminin Correlates to Recovery of Vasogenic Edema following Status Epilepticus
Investigators addressed the question of whether the up-regulation of laminin expression represents the astroglio-vascular responses to status epilepticus in an effort to better understand the role of vasogenic edema in epileptogenic insult. [Neuroscience] Abstract

Distinct Functions of the Laminin Beta LN Domain and Collagen IV during Cardiac Extracellular Matrix Formation and Stabilization of Alary Muscle Attachments Revealed by EMS Mutagenesis in Drosophila
Using an EMS mutagenesis screen for cardiac and muscular abnormalities in Drosophila embryos investigators obtained multiple mutants for two genetically interacting complementation groups that showed similar alary muscle and pericardial cell detachment phenotypes. [BMC Dev Biol] Abstract | Full Article

Bone Tissue Engineering with a Collagen-Hydroxyapatite Scaffold and Culture Expanded Bone Marrow Stromal Cells
The authors developed a collagen-hydroxyapatite scaffold that supports consistent osteogenesis by donor-derived osteoprogenitors, and is more easily degraded than a pure ceramic scaffold. They examined the biological performance in vivo in a critical-size mouse calvarial defect. [J Biomed Mater Res B Appl Biomater] Abstract

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TxCell Receives Certificate of GMP Compliance for Cell Therapy Manufacturing Facility in France
TxCell SA, a biotechnology company developing innovative, personalized cell-based immunotherapies using antigen specific regulatory T-cells for severe chronic inflammatory and autoimmune diseases, announced that it has been granted Certificate of Good Manufacturing Practice (GMP) compliance for its cell therapy manufacturing facility in Besançon, France. [TxCell SA] Press Release

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NEW Scientist – Skin Cell Research (STEMCELL Technologies Inc.)

NEW Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

NEW Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Independent Junior Research Group Leader – Biophysical Aspects of Cell Dynamics, Cell-Cell and/or Cell-Matrix Interactions (Cells in Motion)

Research Associate – Tissue Systems (University of Manchester)

Postdoctoral Associate – Mechanisms of Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF) on Extracellular Matrix (University of Minnesota – Twin Cities)

PhD Research Fellow – Cellular Interactions with the Extracellular Matrix of Tumor Microenvironment (Norwegian University of Science and Technology)

Postdoctoral Position – Proteases and Extracellular Matrix (GENYO)

Postdoctoral Position – 3D Structured Engineered Tissues (Nano Fiber Matrices B.V.)

Postdoctoral Position – Therapeutic Advantages of the Combined Use of Scaffold and Cells for Orthopedic Applications (Bone Therapeutics S.A.)

PhD Position – 3D Structured Self-Assembled Hydrogels for Tissue Engineering (TU Delft)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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