β1-Integrin Alters Ependymal Stem Cell BMP Receptor Localization and Attenuates Astrogliosis after Spinal Cord Injury Researchers demonstrated that expression of β1-integrin increases in ependymal zone stem cells (EZCs) following spinal cord injury in mice. Conditional knock-out of β1-integrin increases GFAP expression and astrocytic differentiation by cultured EZCs without altering oligodendroglial or neuronal differentiation. [J Neurosci] Abstract Modifications in Stromal Extracellular Matrix of Aged Corneas Can Be Induced by Ultraviolet A Irradiation To ascertain the implication of ultraviolet A (UVA) exposure in extracellular matrix changes observed with age in human cornea, scientists developed a model of photoaging by chronically exposing corneal stroma keratocytes with a precise UVA irradiation protocol. Using this model, they analyzed UVA-induced transcriptomic and proteomic changes in corneal stroma. [Aging Cell] Full Article Macromolecularly Crowded In Vitro Microenvironments Accelerate the Production of Extracellular Matrix-Rich Supramolecular Assemblies Investigators assessed the influence of macromolecular crowding, a biophysical phenomenon that regulates intra- and extra-cellular activities in multicellular organisms, in human corneal fibroblast culture. [Sci Rep] Full Article The Anti-Fibrotic Effects of Mesenchymal Stem Cells on Irradiated Lungs via Stimulating Endogenous Secretion of HGF and PGE2 To investigate the specific roles of mesenchymal stem cells in ameliorating radiation-induced pulmonary fibrosis, researchers treated control groups of irradiated rats with human skin fibroblasts or phosphate-buffered saline. After mesenchymal stem cells were infused, host secretions of hepatocyte growth factor (HGF) and prostaglandin E2 (PGE2) were elevated compared with those of the controls. [Sci Rep] Full Article Matrix Stiffness-Modulated Proliferation and Secretory Function of the Airway Smooth Muscle Cells The authors report how airway smooth muscle cells (ASMCs) respond to a change in mechanical stiffness of a matrix, to which ASMCs adhere, because mechanical stiffness of the remodeled airways is often different from the physiological stiffness. [Am J Physiol Lung Cell Mol Physiol] Abstract Estrogen Receptor Alpha Mediates Epithelial to Mesenchymal Transition, Expression of Specific Matrix Effectors and Functional Properties of Breast Cancer Cells Estrogen receptor alpha silencing in MCF-7 cells strongly induced cellular phenotypic changes accompanied by significant changes in gene and protein expression of several markers typical of epithelial to mesenchymal transition. Notably, these cells exhibited enhanced cell proliferation, migration and invasion. [Matrix Biol] Full Article The Roles of Integrins in Function of Human Neutrophils after Their Migration through Endothelium into Interstitial Matrix Scientists investigated the changes in neutrophil phenotype and function after transendothelial migration, and the roles played by integrin receptors in their behavior. [PLoS One] Full Article Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs Investigators developed an approach to generate scaffoldless hyaline cartilage from human induced pluripotent stem cells (hiPSCs). They optimized the culture conditions and found BMP2, transforming growth factor β1, and GDF5 critical for GFP expression and thus chondrogenic differentiation of the hiPSCs. [Stem Cell Rep] Full Article | Graphical Abstract | Press Release |