Regulated Delivery of Molecular Cargo to Invasive Tumor-Derived Microvesicles Investigators demonstrated that in amoeboid-like invasive tumor cell lines, VAMP3 regulates delivery of microvesicle cargo such as the membrane-type 1 matrix metalloprotease to shedding microvesicles. [Nat Commun] Abstract Adhesion of Adipose-Derived Mesenchymal Stem Cells to Glycosaminoglycan Surfaces with Different Protein Patterns. Scientists developed surfaces that display glycosaminoglycans and proteins in a spatially controlled fashion. The generated surfaces can be used as a minimalistic but straightforward model aiding the elucidation of cell-extracellular matrix interactions. [ACS Appl Mater Interfaces] Abstract Fabrication of 3-Dimensional Multicellular Microvascular Structures Researchers evaluated the use of 3-dimensional microfibers fabricated by hydrogel electrospinning as templates for microvascular structure formation. Compared to 2-dimensional cultures, they demonstrated that fibrin microfibers induce an increased extracellular matrix protein deposition by vascular cells. [FASEB J] Abstract Hypoxic Culture of Bone Marrow-Derived Mesenchymal Stromal Stem Cells Differentially Enhances In Vitro Chondrogenesis Within Cell-Seeded Collagen and Hyaluronic Acid Porous Scaffolds The authors assessed the effect of hypoxia on in vitro bone marrow mesenchymal stromal stem cell chondrogenesis within clinically approved porous scaffolds composed of collagen and hyaluronic acid. [Stem Cell Res Ther] Abstract Electrical Stimulation Modulates the Expression of Multiple Wound Healing Genes in Primary Human Dermal Fibroblasts Scientists profiled multiple human dermal fibroblast wound-healing genes in response to electrical stimulation (ES) by using the RT2profiler PCR-Array system. The ES modulated genes are involved in cell adhesion, remodeling and spreading, cytoskeletal activity, extracellular matrix metabolism, production of inflammatory cytokines/chemokines and growth factors, as well as signal transduction. [Tissue Eng Part A] Abstract Intervertebral Disc Tissue Engineering with Natural Extracellular Matrix-Derived Biphasic Composite Scaffolds Investigators developed a novel integrated biphasic intervertebral-disc scaffold using a simple freeze-drying and cross-linking technique of pig bone matrix gelatin for the outer annulus fibrosus phase and pig acellular cartilage extracellular matrix for the inner nucleus pulposus phase. [PLoS One] Full Article Remodeling of Extracellular Matrix by Normal and Tumor-Associated Fibroblasts Promotes Cervical Cancer Progression Researchers indicated that in addition to degradation of the basement membrane, invasion of cervical cancer is accomplished by the remodeling of the interstitial stroma, which includes a decrease and partial replacement of fibronectin and collagens by a laminin-rich matrix. [BMC Cancer] Abstract | Full Article The Notch Pathway Mediates the Angiotensin II-Induced Synthesis of Extracellular Matrix Components in Podocytes Researchers aimed to investigate the effects of the Notch pathway on the synthesis of extracellular matrix components in Angiotensin II (AngII)-stimulated podocytes. They revealed that Ang II upregulated Notch1, Notch intracellular domain 1, hairy and enhancer of split-1, transforming growth factor-β1, type IV collagen and laminin expression and downregulated matrix metalloproteinase (MMP)-2 and MMP-9 expression in the cultured podocytes. [Int J Mol Med] Abstract |