Extracellular Matrix News Volume 6.27 | Jul 16 2015

Dynamic Tensile Forces Drive Collective Cell Migration through Three-Dimensional Extracellular Matrices
Researchers showed directly that migration of multicellular cohorts through collagenous matrices occured via a dynamic pulling mechanism, the nature of which had only been inferred previously in three-dimensions. [Sci Rep] Full Article

Extracellular Matrix Properties Regulate the Migratory Response of Glioblastoma Stem Cells in 3D Culture
Scientists developed a composite matrix of hyaluronan structurally supported by a collagen-oligomer fibril network to simulate the brain-tumor extracellular matrix composition. [Tissue Eng Part A] Abstract

Laminin Promotes Metalloproteinase Mediated Dystroglycan Processing to Regulate Oligodendrocyte Progenitor Cell Proliferation
Researchers report that oligodendroglial dystroglycan is cleaved by metalloproteinases, thereby uncoupling oligodendroglia from laminin binding. [J Neurochem] Abstract

The Cytoskeleton Regulates Cell Attachment Strength
Scientists showed that focal adhesion proteins FAK, paxillin, and vinculin but not the cytoskeletal protein actin remained behind after shear-induced detachment of HT1080 fibrosarcoma cells. [Biophys J] Abstract

3D Multi-Layered Fibrous Cellulose Structure Using an Electrohydrodynamic Process for Tissue Engineering
Researchers suggest a new three-dimensional (3D) cellulose scaffold consisting of multi-layered struts made of submicron-sized entangled fibers that were fabricated using an electrohydrodynamic direct jet process that is spin-printing. [J Colloid Interface Sci] Abstract

Corneal Regeneration by Deep Anterior Lamellar Keratoplasty (DALK) Using Decellularized Corneal Matrix
The authors demonstrated the feasibility of DALK using a decellularized corneal matrix obtained by HHP methodology. [PLoS One] Full Article

MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma
Increased miR-375 expression in head and neck squamous cell carcinoma cells suppressed extracellular matrix degradation and reduced the number of mature invadopodia. Higher miR-375 expression did not reduce cellular levels of selected invadopodia-associated proteins, nor was tyrosine phosphorylation of cortactin altered. [Arch Pathol Lab Med] Abstract

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CSU Awarded $1.3 Million NIH Grant for Stem Cell Research
Moo-Yeal Lee, Ph.D., and Chandra Kothapalli, Ph.D., of Cleveland State University (CSU) have been awarded a $1.3 million grant from the National Institutes of Health for innovative stem cell research to improve testing for toxic compounds that could harm the development of the human brain. [Cleveland State University] Press Release

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NEW Research Fellow – Tissue Engineering & Regenerative Medicine (National Cancer Centre Singapore)

Biomedical Engineer – Cell Therapies & Regenerative Medicine (FDA’s Center for Biologics Evaluation and Research)

PhD Position – Drug Releasing, Nanostructured Biomaterials for Adult Stem Cells (Karlsruhe Institute of Technology)

Associate Scientist – Biomedical Engineering (Shanghai Jiao Tong University)

Postdoctoral Fellow – Stem Cell Biology (INSERM)

Postdoctoral Position – Proteoglycan and Dislocations (Inserm)

PhD Position – Tumor Biology (University of Duisburg-Essen)

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