Extracellular Matrix News Volume 6.46 | Nov 26 2015

Extracellular Mipp1 Activity Confers Migratory Advantage to Epithelial Cells during Collective Migration
Scientists characterized Drosophila multiple inositol polyphosphate phosphatase 1 (mipp1). They showed that Mipp1 facilitates formation and/or stabilization of filopodia in leading cells through its extracellular activity. [Cell Rep] Full Article | Graphical Abstract | Press Release

RA-XII Inhibits Tumor Growth and Metastasis in Breast Tumor-Bearing Mice via Reducing Cell Adhesion and Invasion and Promoting Matrix Degradation
Researchers investigated the in vitro effects of cyclopeptide glycoside, RA-XII on cell adhesion, invasion, proliferation and matrix degradation, and its underlying mechanism in murine breast tumor cells, 4T1. [Sci Rep] Full Article

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes
Researchers designed a defined differentiation process using recombinant laminin substrates to provide instruction. They demonstrated efficient hepatocyte specification, cell organization, and significant improvements in cell function and phenotype. [Stem Cell Rep] Full Article | Press Release

Characterization of a Novel Collagen Scaffold for Corneal Tissue Engineering
Scientists characterized the physical and biological properties of a novel collagen-based scaffold. In vitro biocompatibility was assessed by culturing the scaffold with epithelial or keratocyte spheres. [Tissue Eng Part C Methods] Abstract

Elastoviscous Transitions of Articular Cartilage Reveal a Mechanism of Synergy between Lubricin and Hyaluronic Acid
Investigators developed a novel framework for cartilage lubrication based on the elastoviscous transition to show that lubricin and hyaluronic acid lubricate by distinct mechanisms. [PLoS One]
Full Article | Press Release

Three-Dimensional Platelet-Rich Plasma Hydrogel Model to Study Early Tendon Healing
Scientists compared the culture of human tendon cells in two dimensions with platelet-rich plasma (PRP)‑supplemented media to culture in matching three-dimensional PRP hydrogels. Cell proliferation, cell shape, and the pattern of gene and protein expression were examined. [Cells Tissues Organs] Abstract

Arterial Decellularized Scaffolds Produced Using an Innovative Automatic System
Researchers developed an innovative system for the automatic decellularization of blood vessels, used to process pig arteries. Outcomes showed scaffolds with no cellular or nuclear remnants and a well-preserved tissue structure, corroborated by mechanical properties similar to native tissue. [Cells Tissues Organs] Abstract

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Halozyme to Expand with a Satellite Office in San Francisco
Halozyme Therapeutics, Inc., a biotechnology company developing novel oncology and drug-delivery therapies, announced it will be expanding its facilities by opening a satellite office in San Francisco. [Halozyme Therapeutics, Inc.] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Professor – Bioengineering (University of Colorado Denver and Anschutz Medical Campus)

Postdoctoral Position – Scaffold Design & Drug/Gene Delivery for Neural Tissue Engineering (Nanyang Technological University)

Postdoctoral Position – Stem Cell Engineering Research (Nanyang Technological University)

Postdoctoral Position – hPSC-Derived Cardiomyocyte Grafts in Injured Hearts (University Health Network)

Faculty Position – Neuromuscular Bioengineering (Northwestern University)

Postdoctoral Position – Structural Studies of Bacterial Protein Secretion (University of Brussels)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Position – Biomaterials for Cell Reprogramming (Institute of Tissue Regeneration Engineering)

Director – Clinical Development (Novadip Biosciences)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

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