Extracellular Matrix News Volume 6.49 | Dec 17 2015

bFGF Binding Cardiac Extracellular Matrix Promotes the Repair Potential of Bone Marrow Mesenchymal Stem Cells in a Rabbit Model for Acute Myocardial Infarction
Investigators assessed the effect of basic fibroblast growth factor-binding extracellular matrix combined with bone marrow mesenchymal stem cells transplantation on acute myocardial infarction and explored the underlying mechanisms. [Biomed Mater] Abstract

Effects of the Scaffold Proteins Liprin-α1, β1 and β2 on Invasion by Breast Cancer Cells
Liprin-α1 promotes invasion by supporting the protrusive activity at the leading edge of the migrating tumor cell and the degradation of the extracellular matrix by invadopodia. Researchers addressed the role of liprin-α1 in the invasive process in vivo. [Biol Cell] Abstract

Effects of Mesenchymal Stem Cell Treatment on the Expression of Matrix Metalloproteinases and Angiogenesis during Ischemic Stroke Recovery
Scientists investigated the optimal time point of mesenchymal stem cell (MSC) transplantation. After MSC treatment, they also investigated the expression of matrix metalloproteinases, which play a role in vascular and tissue remodeling. [PLoS One] Full Article

Collagen Promotes Higher Adhesion, Survival and Proliferation of Mesenchymal Stem Cells
Researchers studied the effect of extracellular matrix proteins in controlling cell survival, proliferation, migration and directed mesenchymal stem cell differentiation. They found that collagen promoted cell proliferation, cell survival under stress and promoted high cell adhesion to the cell culture surface. [PLoS One] Full Article

In Vitro Evaluation of Decellularized ECM-Derived Surgical Scaffold Biomaterials
Scientists investigated scaffolds derived from dermis, small intestinal submucosa, and mesothelium and evaluated biological properties that modulate cellular responses and recruitment. An assay panel was utilized to assess the extracellular matrix (ECM) scaffold effects upon cells. [J Biomed Mater Res B Appl Biomater] Abstract

Direct E-Jet Printing of Three-Dimensional Fibrous Scaffold for Tendon Tissue Engineering
Investigators report the development of a novel electrohydrodynamic jet printing for engineering 3D tendon scaffold with high porosity and orientated micrometer-size fibers. [J Biomed Mater Res B Appl Biomater] Abstract

The Effects of High-Fat Feeding on Physical Function and Skeletal Muscle Extracellular Matrix
The authors demonstrated links between muscle extracellular matrix structure and physical function in obesity. [Nutr Diabetes] Full Article

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New Center Focuses on Regenerative Medicine
A new center has been formed at Washington University School of Medicine in St. Louis to facilitate research that explores the regenerative properties of cells and tissues. The goal of the Center of Regenerative Medicine is to develop new medical treatments that might one day allow doctors to regrow or replace a damaged heart or severed nerves, or restore lost vision or hearing. [Washington University in St. Louis] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Postdoctoral Fellow – Interactions between Innate Immunity and Extracellular Matrix in Joint Diseases (Lund University)

Postdoctoral Fellow – Statistical Analysis of Cell Migration (Karolinska Institutet)

PhD Position – Cancer Research and Wound Healing (Technion, Israel Institute of Technology)

Postdoctoral Position – Cell Mechanobiology (Washington University in St. Louis)

Research Associate – Cell Biology/Biophysics (University College London)

Postdoctoral Position – Scaffold Design & Drug/Gene Delivery for Neural Tissue Engineering (Nanyang Technological University)

Postdoctoral Position – Stem Cell Engineering Research (Nanyang Technological University)

Postdoctoral Position – hPSC-Derived Cardiomyocyte Grafts in Injured Hearts (University Health Network)

Postdoctoral Research Fellow – Ex Vivo Tumor Organoid Models (Fred Hutchinson Cancer Research Center)

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