Neuronal Heparan Sulfates Promote Amyloid Pathology by Modulating Brain Amyloid-β Clearance and Aggregation in Alzheimer’s Disease Investigators found that the amounts of various heparan sulfate proteoglycans were increased in postmortem human brain tissues from Alzheimer’s disease patients, suggesting that this pathway may contribute directly to amyloid pathogenesis. [Sci Transl Med] Abstract | Press Release Host Selection of Microbiota via Differential Adhesion Scientists’ simulations predict that host-mediated adhesion can increase the competitive advantage of microbes and create ecological refugia for slow-growing species. They showed how positive selection via adhesion can be transformed into negative selection if the host secretes large quantities of a matrix such as mucus. [Cell Host Microbe] Abstract | Graphical Abstract | Press Release PDGF-AB and 5-Azacytidine Induce Conversion of Somatic Cells into Tissue-Regenerative Multipotent Stem Cells Investigators report that transient treatment with 5-Azacytidine in combination with platelet-derived growth factor–AB (PDGF-AB) converts primary somatic cells into tissue-regenerative multipotent stem (iMS) cells. Importantly, unlike mesenchymal stem cells, iMS cells contribute directly to in vivo tissue regeneration in a context-dependent manner and, unlike embryonic or pluripotent stem cells, do not form teratomas. [Proc Natl Acad Sci USA] Abstract | Press Release | Video Matrix Stiffness-Mediated Effects on Stemness Characteristics Occurring in HCC Cells Investigators explored whether matrix stiffness-mediated effects on stemness characteristics occur in HCC cells. As the substrate stiffness increased, HCC cells exhibited high proportion of cells with CD133+/EpCAM+, high expression levels of CD133, EpCAM, Nanog and SOX2, greater self-renewing ability and oxaliplatin resistance. [Oncotarget] Full Article Short-Chain Ceramides Depress Integrin Cell Surface Expression and Function in Colorectal Cancer Cells Scientists determined the impact of ceramide, which plays a key modulatory role in cancer suppression, on integrin cell surface expression and function in colorectal cancer cells in order to reveal possible ceramide-centric effects on tumor cell motility. [Cancer Lett] Abstract A Novel Fibroblast Growth Factor Receptor 1 Inhibitor Protects against Cartilage Degradation in a Murine Model of Osteoarthritis Researchers investigated the effect of a novel non-ATP-competitive fibroblast growth factor receptor 1 inhibitor, G141, on the catabolic events in human articular chondrocytes and cartilage explants and on the progression of cartilage degradation in a murine model of osteoarthritis. [Sci Rep] Full Article Molecular Basis of the Ligand-Binding Specificity of αvβ8 Integrin Researchers comprehensively determined the binding activity of αvβ8 integrin towards 25 secreted proteins having an Arg-Gly-Asp (RGD) motif. αvβ8 integrin strongly bound to latent TGF-β1 but showed marginal activity for other RGD-containing proteins including fibronectin and vitronectin. [J Biol Chem] Abstract | Full Article The Integrin-Mediated ILK-Parvin-αPix Signaling Axis Controls Differentiation in Mammary Epithelial Cells Expression of integrin linked kinase (ILK) mutants, which weaken the interaction between ILK and Parvin, revealed that Parvins have a role in mammary epithelial differentiation. [J Cell Physiol] Abstract Understanding the Role of ECM Protein Composition and Geometric Micropatterning for Engineering Human Skeletal Muscle Scientists investigated microenvironmental cues that drive myoblast differentiation into aligned myotubes for potential applications in skeletal muscle repair, organ-on-chip disease models and actuators for soft robotics. They used a 2D in vitro system to systematically evaluate the role of extracellular matrix (ECM) protein composition and geometric patterning for controlling the formation of highly aligned myotubes. [Ann Biomed Eng] Abstract |