Laminin-111 Peptides Conjugated to Fibrin Hydrogels Promote Formation of Lumen Containing Parotid Gland Cell Clusters Researchers created three-dimensional salivary cell clusters using a modified fibrin hydrogel matrix containing immobilized Laminin-111 peptides. They indicated that the YIGSR peptide improved morphology and lumen formation in rat parotid Par-C10 cells as compared to cells grown on unmodified fibrin hydrogel. [Biomacromolecules] Abstract PDL Progenitor–Mediated PDL Recovery Contributes to Orthodontic Relapse Force-triggered orthodontic tooth movement and the following relapse were used as models to demonstrate the response of periodontal ligament (PDL) progenitors and their role in PDL remodeling upon and after mechanical force. Upon orthodontic force, PDL collagen on the compression side significantly degraded, showing a broken and disorganized pattern. [J Dent Res] Abstract E2 Regulates MMP-13 via Targeting miR-140 in IL-1β-Induced Extracellular Matrix Degradation in Human Chondrocytes Investigators aimed to determine the role of miR-140 in the estrogen-dependent regulation of matrix metallopeptidase 13 (MMP-13) in human chondrocytes. [Arthritis Res Ther] Full Article Optimization of Liver Decellularization Maintains Extracellular Matrix Micro-Architecture and Composition Predisposing to Effective Cell Seeding The authors aimed to develop a decellularization technique that reliably maintains hepatic microarchitecture and extracellular matrix components. [PLoS One] Full Article Simulation of Extracellular Matrix Remodeling by Fibroblast Cells in Soft Three-Dimensional Bioresorbable Scaffolds Scientists hypothesized that individual cells are capable of remodeling extracellular matrix within a short proximity of themselves in order to match the stiffness of the broader surrounding matrix. This theory was implemented in a three-dimensional finite element model to simulate soft tissue remodeling of human fibroblast cells in two collagen–chitosan scaffolds with different mechanical properties. [Biomech Model Mechanobiol] Abstract Soft-Matrices Based on Silk Fibroin and Alginate for Tissue Engineering Investigators described the development of hydrogels based on the blend between alginate and silk fibroin. They report two main strategies to combine cells with biomaterials: cells are either seeded onto prefabricated hydrogels films, or encapsulated during hydrogel microcapsules formation. [Int J Biol Macromol] Abstract Transfer of Fibroblast Sheets Cultured on Thermoresponsive Dishes with Membranes Researchers evaluated plates covered with thermoresponsive polymers as supports for the formation of fibroblast sheets and developed a damage-free procedure for cell sheet transfer with the use of membranes as transfer tools. [J Mater Sci Mater Med] Full Article Carboxy-Terminal Modulator Protein Attenuated Extracellular Matrix Deposit by Inhibiting Phospho-Akt, TGF-β1 and α-SMA in Kidneys of Diabetic Mice Renal decreased carboxy-terminal modulator protein, enhanced phospho-Akt (Ser 473), TGF-β1, α-SMA and extracellular matrix deposit were found in diabetic mice. [Biochem Biophys Res Commun] Abstract |