Extracellular Matrix News Volume 7.24 | Jun 23 2016

TOP STORY

Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves

The authors aimed to elucidate the specific functions of cadherin-11 and its downstream targets, RhoA and Sox9, in extracellular matrix remodeling and aortic valve calcification. [Arterioscler Thromb Vasc Biol] Abstract

(Ranked by impact factor of the journal)

Bile Canaliculi Formation and Biliary Transport in 3D Sandwich-Cultured Hepatocytes in Dependence of the Extracellular Matrix Composition

Scientists investigated the influence of different extracellular matrix compositions on morphology, cellular arrangement and bile canaliculi formation as well as bile excretion processes in primary human hepatocytes sandwich cultures systematically. [Arch Toxicol] Abstract

3D Bioprinting Using a Templated Porous Bioink

3D tissue printing with adult stem cells was reported. A novel cell-containing multicomponent bioink was used in a two-step 3D printing process to engineer bone and cartilage architectures [Adv Healthc Mater] Full Article | Press Release

Cadherin-11 Is a Novel Regulator of Extracellular Matrix Synthesis and Tissue Mechanics

Scientists discovered that cadherin-11 (CDH11) regulates collagen and elastin synthesis both affecting the mechanical properties and contractile function of animal tissues. Using a Cdh11 null mouse model, they observed a significant reduction in the mechanical properties of Cdh11^−/− as compared to wild type mouse tissues, such as aorta, bladder and skin. [J Cell Sci] Abstract

Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis

Researchers report the effect of a Th2 cell product, extracellular matrix protein 1 (ECM1), on the differentiation of Th17 cells and the development of experimental autoimmune encephalomyelitis (EAE). They demonstrated that ECM1 administration from day one to day seven following the EAE induction could ameliorate the Th17 cell responses and EAE development in vivo. [J Immunol] Abstract

Randomized Controlled Clinical Study Evaluating Effectiveness and Safety of a Volume-Stable Collagen Matrix Compared to Autogenous Connective Tissue Grafts for Soft Tissue Augmentation at Implant Sites

The authors tested whether or not the use of a collagen matrix (VCMX) results in short-term soft tissue volume increase at implant sites non-inferior to an autogenous subepithelial connective tissue graft (SCTG) and evaluated safety and tissue integration of VCMX and SCTG. [J Clin Periodontol] Abstract

Biological Functionality and Mechanistic Contribution of Extracellular Matrix-Ornamented Three Dimensional Ti-6Al-4V Mesh Scaffolds

Investigators elucidated the effect of cell-derived decellularized extracellular matrix ornamented 3D printed Ti-6Al-4V scaffolds on biological functions, involving cell adhesion, proliferation, and synthesis of vinculin and actin proteins. [J Biomed Mater Res A] Abstract

An Evaluation of Matrix-Containing and Humanised Matrix-Free 3-Dimensional Cell Culture Systems for Studying Breast Cancer

Scientists compared the efficacy of three different 3D cell culture systems; collagen I, low attachment culture vessels and a modification of Fibrolife^®, a specialized humanized cell culture medium devoid of animal-derived components, using breast cancer cell lines representative of the different molecular subtypes of breast cancer, cultured alone or with human mammary fibroblasts with a view to developing matrix-free humanized systems. [PLoS One] Full Article

Quantitative Analysis of 3D Extracellular Matrix Remodelling by Pancreatic Stellate Cells

Researchers present an integrated methodology where cell-extracellular matrix (ECM) interactions can be investigated in 3D environments via ECM remodelling. Monitoring and quantification of collagen-I structure in remodelled matrices, through designated algorithms, show that 3D matrices can be used to correlate remodelling with increased ECM stiffness observed in fibrosis. [Biol Open] Full Article

The Impact of Decellularization Agents on Renal Tissue Extracellular Matrix

The impact of five decellularization agents on renal tissue was examined using slices of porcine kidneys. The NaOH solution induced the most efficient cell removal, and resulted in the highest amount of cell viability and proliferation after recellularization, although it also produced the most significant damage to collagenous fiber networks, glycosaminoglycans and fibroblast growth factor. [J Biomater Appl] Abstract

Extracellular Matrix for Vocal Fold Lamina Propria Replacement: A Review

The authors explored the concept of tissue engineering as it relates to the vocal folds (VFs) as well as recent studies employing both naturally- and synthetically-derived biomaterials, including those from laryngeal and non-laryngeal sources, in combination with stem cells for a tissue-engineered approach to VF repair. [Tissue Eng Part B Rev] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

CorMatrix^® Cardiovascular, Inc. Treats First Patients with New Tyke^® Product for Neonates and Infants

CorMatrix Cardiovascular, Inc. announced the treatment of the first patients using its CorMatrix^® Tyke^®, a product specifically designed and cleared for cardiac tissue repairs in neonates and infants. [CorMatrix Cardiovascular, Inc.] Press Release

AlloSource Announces Two Innovative Bone Fiber Allografts

AlloSource announced the launch of two new innovative demineralized cortical fiber allografts, AlloFuse^® Cortical Fibers and the AlloFuse^® Fiber Boat, for use in a variety of spine and orthopedic procedures. [AlloSource] Press Release

NEW European Society for Medical Oncology (ESMO) 2016
October 7-11, 2016
Copenhagen, Denmark

Visit our events page to see a complete list of events in the extracellular matrix community.

NEW Postdoctoral Positions – Vascular Biology and Metabolism (University of Pittsburgh Medical Center)

Postdoctoral Scientist – Inflammatory Mechanisms Involved in Aortic Aneurysm (NYU Langone Medical Center)

Postdoctoral Position – Angiogenesis, Proteases and Extracellular Matrix (GENYO)

Postdoctoral Research Fellow – Musculoskeletal Regenerative Medicine (Queen Mary University of London)

Postdoctoral Scientist – Intracellular Calcium Cycling (Cedars-Sinai Heart Institute)

Postdoctoral Position – Biomechanics (Massachusetts General Hospital & Harvard Medical School)

Postdoctoral Fellow – Genome Editing for Striated Muscle Regeneration (Duke University)

MSc Position – Extracellular Matrix Genes during Aging (ETH Zurich)

Postdoctoral Position – Extracellular Matrix Genes during Aging (ETH Zurich)

Postdoctoral Fellow – Cervical Extracellular Matrix (University of Texas Southwestern Medical Center)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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