Extracellular Matrix News 7.27 July 14, 2016 | |
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TOP STORYResearchers determined if the incorporation of chitosan into collagen scaffolds could improve the mechanical and biological properties of the scaffold. In addition they assessed if collagen, derived from salmon skin, can provide an alternative to collagen derived from bovine tendon for tissue engineering applications. [Acta Biomater] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators assessed stem cell chondrogenesis within extracellular matrix-derived scaffolds loaded with escalating levels of transforming growth factor-β3. [J Tissue Eng Regen Med] Abstract Researchers tested the hypothesis that native cardiac extracellular matrix (ECM) and three-dimensional (3D) cultures might enhance the maturation of induced pluripotent stem cells (iPSC)-derived cardiomyocytes (CMs) in vitro. They demonstrated that maturation of iPSC-derived CM was enhanced when cells were seeded into a 3D cardiac ECM scaffold, compared to two-dimensional culture. [Tissue Eng Part A] Abstract The authors investigated the capacity for high fat diet-induced obesity to alter adipose-derived stromal cell relative quantity and extracellular matrix gene expression, and determine the extent to which exercise training can mitigate such changes. [Stem Cell Res] Abstract Scientists found that extracellular matrix alignment induced spatial anisotropy of cells’ matrix probing by promoting protrusion frequency, persistence, and lengthening along the alignment axis and suppressing protrusion dynamics orthogonal to alignment. [Integr Biol] Abstract Researchers present a microfluidic chip-based tumor tissue culture model that integrates 3D tumor spheroids (TSs) with cancer-associated fibroblast in proximity within a hydrogel scaffold. HT-29 human colorectal carcinoma cells grew into 3D TSs and the growth was stimulated when co-cultured with fibroblasts as shown by a 1.5-fold increase in diameter over five days. [PLoS One] Full Article Investigators developed a procedure that can enable decellularization and recellularization of intact articular cartilage matrix. [PLoS One] Full Article Scientists found that a high concentration of extracellular Mg2+ inhibited the mineralization of the extracellular matrix in tendon-derived stem cells and that 100 μM ATP reversed this inhibitory effect in vitro. [Biochem Biophys Res Commun] Abstract The authors investigated the expression and the biological function of microRNA-34a in intervertebral disc degeneration. In this study, microRNA-34a expression was assessed in nucleus pulposus specimens and in IL-1β-stimulated nucleus pulposus cells by real-time polymerase chain reaction. [Exp Biol Med] Abstract Synthetic Hydrogel Supports the Function and Regeneration of Artificial Ovarian Tissue in Mice Investigators engineered an artificial ovarian tissue from immature follicles using a synthetic hydrogel, poly(ethylene glycol) vinyl sulfone, as a supportive matrix. [npj Regen Med] Full Article | |
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REVIEWSMechanotransduction Pulls the Strings of Matrix Degradation at Invadosome The authors present recent findings in protease-dependent mechanisms elucidating the ways the force affects extracellular matrix degradation by targeting protease expression and activity at invadosome. [Matrix Biol] Abstract The authors aim to address the advances and challenges concerning the design, development, and current status of anti-matrix metalloproteinase (MMP) agents in this new era of post-broad-spectrum MMP inhibitors. [Metalloproteinases Med] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.
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INDUSTRY NEWSTELA Bio, Inc. announced the commercial launch of the company’s OviTexâ„¢ portfolio of products for use in ventral hernia repair and abdominal wall reconstruction following U.S. Food and Drug Administration 510(K) clearance. [TELA Bio, Inc. (PR Newswsire Association LLC.)] Press Release First Patient Is Randomized in STEMTRA Trial for Traumatic Brain Injury SanBio, Inc. announced the randomization of the first patient in the STEMTRA Phase II clinical trial study for traumatic brain injury. [SanBio, Inc.] Press Release | |
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POLICY NEWSAfter Protest, Canada’s Health Science Funder Reverses Course on Peer-Review Changes Canada’s scientific community carved a major notch in its belt by successfully forcing Canadian Institutes of Health Research President Alain Beaudet into a partial retreat from his controversial introduction of online peer review. [ScienceInsider] Editorial Science’s Status Shifts in New Brexit Government Three weeks after UK voters chose to leave the European Union, the country has a new prime minister, Theresa May — and a revamped administration that is poised to change science’s place in government. [Nature News] Editorial Beat It, Impact Factor! Publishing Elite Turns against Controversial Metric A paper posted to the preprint server bioRxiv, authored by senior employees at several leading science publishers (including Nature’s owner, SpringerNature), calls on journals to downplay the figure in favor of a metric that captures the range of citations that a journal’s articles attract. [Nature News] Editorial | Article The Past, Present and Future of the PhD Thesis According to one of those often-quoted statistics that should be true but probably isn’t, the average number of people who read a PhD thesis all the way through is 1.6. And that includes the author. More interesting might be the average number of PhD theses that the typical scientist — and reader of Nature — has read from start to finish. [Nature News] Editorial Major Funders Launch International Repository of Cutting-Edge Cancer Models U.S. and European funding agencies are launching the Human Cancer Models Initiative, which aims to give the research community tumor cells that behave more like actual human tumors. [ScienceInsider] Editorial
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EVENTSNEW 4th International Oncology Conference Visit our events page to see a complete list of events in the extracellular matrix community.
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JOB OPPORTUNITIESNEW PhD Student – Regenerative Therapies (Universitätsklinikum Carl Gustav Carus Dresden) NEW Postdoctoral Positions – Regenerative Engineering (The University of Queensland) Faculty Positions – Cell Biology and Physiology (Washington University School of Medicine) Postdoctoral Positions – Vascular Biology and Metabolism (University of Pittsburgh Medical Center) Postdoctoral Position – Angiogenesis, Proteases and Extracellular Matrix (GENYO) Postdoctoral Scientist – Intracellular Calcium Cycling (Cedars-Sinai Heart Institute) Postdoctoral Position – Biomechanics (Massachusetts General Hospital & Harvard Medical School) Postdoctoral Position – Extracellular Matrix Genes during Aging (ETH Zurich) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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