Extracellular Matrix News Volume 7.28 | Jul 21 2016

TOP STORY

Glutathione Peroxidase 3 Localizes to the Epithelial Lining Fluid and the Extracellular Matrix in Interstitial Lung Disease

In lung tissue homogenates, glutathione peroxidase 3 (Gpx3), but not superoxide dismutase 3, was upregulated and detergent solubility profiling indicated that Gpx3 associated with extracellular matrix proteins. [Sci Rep] Full Article

(Ranked by impact factor of the journal)

Lymphocytes Influence Intracranial Aneurysm Formation and Rupture: Role of Extracellular Matrix Remodeling and Phenotypic Modulation of Vascular Smooth Muscle Cells

Lymphocyte-deficient and wild-type mice were subjected to a robust intracranial aneurysm (IA) induction protocol. Rates of IA formation and rupture were measured, and cerebral artery tissue was collected and utilized for histology and gene expression analysis. [J Neuroinflammation] Full Article

Liver Extracellular Matrix Promotes BM-MSCs Hepatic Differentiation and Reversal of Liver Fibrosis through Activation of Integrin Pathway

Researchers investigated the hepatogenicity and underlying mechanism of liver-specific ECM (L-ECM) as well as its potential regulative role in the mesenchymal stem cell-based liver recovery. L-ECM was prepared by homogenization of decellularized whole porcine liver. [J Tissue Eng Regen Med] Abstract

Stimulatory Effects of Advanced Glycation Endproducts (AGEs) on Fibronectin Matrix Assembly

Cellular changes due to AGE accretion in the extracellular matrix (ECM) were investigated. Non-enzymatic glycation of proteins in a decellularized fibroblast ECM was achieved by incubating the ECM in a solution of methylglyoxal. [Matrix Biol] Abstract

Filamin A Regulates the Organization and Remodeling of the Pericellular Collagen Matrix

Investigators examined the role of the actin-binding protein, filamin A (FLNa), in pericellular collagen remodeling. Compared with wild-type, mice with fibroblast-specific deletion of FLNa exhibited higher density but reduced organization of collagen fibers after increased loading of the periodontal ligament for 2 weeks. [FASEB J] Abstract

Extracellular Matrix Composition Defines an Ultra-High-Risk Group of Neuroblastoma within the High-Risk Patient Cohort

Scientists used advanced morphometric approaches to quantify and characterize blood vessels, reticulin fibre networks, collagen type I bundles, elastic fibres and glycosaminoglycans in 102 high-risk neuroblastomas specimens. [Br J Cancer] Abstract

Extracellular Heat Shock Protein 90 Binding to TGFβ Receptor I Participates in TGFβ-Mediated Collagen Production in Myocardial Fibroblasts

Extracellular heat shock protein 90 (Hsp90) inhibition lessened the yield of collagen production as well as the canonical transforming growth factor β (TGFβ) signaling cascade, and collagen protein synthesis was drastically reduced in Hsp90aa1 KO mice. [Cell Signal] Abstract

3D Bioprinting of BM-MSCs-Loaded ECM Biomimetic Hydrogels for In Vitro Neocartilage Formation

Scientists demonstrated how to print 3D biomimetic hydrogel scaffolds for cartilage tissue engineering with high cell density, high cell viability and high printing resolution through a two coaxial-needles system. After printing, samples were cultured in expansion and chondrogenic media to evaluate the possible differentiating effect exerted by the biomimetic matrix or the synergistic effect of the matrix and chondrogenic supplements. [Biofabrication] Abstract

3D Meshes of Carbon Nanotubes Guide Functional Reconnection of Segregated Spinal Explants

Researchers showed that a multiwalled carbon nanotube self-standing framework, consisting of a three-dimensional (3D) mesh of interconnected, conductive, pure carbon nanotubes, can guide the formation of neural webs in vitro where the spontaneous regrowth of neurite bundles is molded into a dense random net. [Sci Adv] Abstract

Polymers, Scaffolds and Bioactive Molecules with Therapeutic Properties in Osteochondral Pathologies: What’s New?

The authors describe current and recent strategies of enhancing osteochondral repair through the use of cells, scaffolds, and bioactive molecules. They review the latest innovative patents in osteochondral regeneration, emphasizing novel strategies for articular cartilage repair. Finally, they present a summary of ongoing clinical trials that are testing innovative engineered products. [Expert Opin Ther Pat] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Regeneron Announces 2016 Winners of the Regeneron Prize for Creative Innovation

Regeneron Pharmaceuticals, Inc. announced the winners of the fourth annual Regeneron Prize for Creative Innovation, an award designed to acknowledge, reward and foster talented early-career biomedical scientists. This year, Regeneron awarded $155,000 in prize money to 10 awardees and two institutions. [Regeneron Pharmaceuticals, Inc.] Press Release

Investing in Cures for Cancer: GE Poised to Lead Industrialization of Cell Therapy Industry with Acquisition of Biosafe Group SA

GE Healthcare has acquired Biosafe Group SA, a supplier of integrated cell bioprocessing systems for the rapidly growing cell therapy and regenerative medicine industry for an undisclosed sum. [GE Healthcare] Press Release

Chinese Scientists to Pioneer First Human CRISPR Trial

Chinese scientists are on the verge of being first in the world to inject people with cells modified using the CRISPR–Cas9 gene-editing technique. A team led by Lu You, an oncologist at Sichuan University’s West China Hospital in Chengdu, plans to start testing such cells in people with lung cancer next month. [Nature News] Editorial

Dutch Agency Launches First Grants Program Dedicated to Replication

The Netherlands has launched what researchers say is the world’s first national fund dedicated to replication studies: a pot of €3 million over the next 3 years for Dutch scientists to test whether they can reproduce important research results in social and medical sciences. [Nature News] Editorial

First Greek Science Agency Is Rare Source of Joy for Beleaguered Researchers

A massive loan from the European Union’s investment bank gives Greek researchers their first ray of hope since the debt crisis hit six years ago: a government-backed plan to create a Greek research agency. [Nature News] Editorial

NEW 11^th International BMP Conference
October 26-30, 2016
Boston, United States

Visit our events page to see a complete list of events in the extracellular matrix community.

NEW Postdoctoral Scientist – Liver Research (Foundation for Liver Research)

PhD Student – Regenerative Therapies (Universitätsklinikum Carl Gustav Carus Dresden)

Postdoctoral Positions – Regenerative Engineering (The University of Queensland)

Postdoctoral Researcher – Enamel Proteins and Biomineralization (University of California, San Francisco)

Faculty Positions – Cell Biology and Physiology (Washington University School of Medicine)

Postdoctoral Positions – Vascular Biology and Metabolism (University of Pittsburgh Medical Center)

Postdoctoral Scientist – Inflammatory Mechanisms Involved in Aortic Aneurysm (NYU Langone Medical Center)

Postdoctoral Position – Angiogenesis, Proteases and Extracellular Matrix (GENYO)

Postdoctoral Position – Extracellular Matrix Genes during Aging (ETH Zurich)

Postdoctoral Fellow – Cervical Extracellular Matrix (University of Texas Southwestern Medical Center)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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