Extracellular Matrix News 7.33 August 25, 2016 | |
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TOP STORYThe authors determined if an extracellular matrix hydrogel therapy could influence outcomes in an inducible rodent model of ulcerative colitis. [J Crohns Colitis] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators developed a combinatorial extracellular matrix (ECM) microarray platform to simultaneously interrogate hundreds of micro-scale multi-component chemical compositions of ECMs on induced pluripotent stem cell-derived endothelial cell response. [Acta Biomater] Abstract Investigators evaluated the potential of keratocytes to produce collagen type II via phenotypic reprogramming with exogenous chondrogenic factors. [Exp Cell Res] Abstract The authors directly implicate first type III repeat of fibrillar fibronectin (FNIII1H) in realignment of stress fibers in human umbilical vein endothelial cells, and, importantly, showed that the matricryptic heparin-binding RWRPK sequence located in FNIII1 is required for the response. [Am J Physiol Heart Circ Physiol] Abstract Scientists investigated the behavior of adipose-derived mesenchymal stromal/stem cells in the context of a cell-derived matrix so as to model the in vivo physiological microenvironment. [Int J Mol Sci] Full Article Investigators tested the hypothesis that repair of volumetric muscle loss injury concomitant to fracture with a small intestine submucosa-extracellular matrix improves musculoskeletal healing. [J Trauma Acute Care Surg] Abstract Researchers elucidated the effect of parathyroid hormone on TGF-β1 and high glucose-induced upregulation of extracellular matrix proteins in primary mesangial cells from Sprague-Dawley rat. [Biochem Biophys Res Commun] Abstract Scientists investigated the effects of NLRC5 on keloid fibroblasts (KFs) and transforming growth factor-β1 (TGF-β1)-induced collagen expression and explored the underlying mechanism. They observed that NLRC5 mRNA and protein levels were highly expressed in KFs, silencing NLRC5 greatly suppressed TGF-β1-induced KFs proliferation. [Biomed Pharmacother] Abstract Researchers investigated the effects of intrinsic spatial heterogeneities due to fibrillar architecture, pore size and ligand density on the microscale and bulk mechanical properties of the extracellular matrix. [Cell Mol Bioeng] Abstract | |
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REVIEWSThe authors describe the extracellular matrix components of the muscle stem cell niche, as well as the influence of exercise and aging on the muscle stem cell niche. [J Appl Physiol] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSTivorsan Pharmaceuticals, Inc. announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to its lead investigational drug, human recombinant Biglycan, for the treatment of Duchenne muscular dystrophy. [Tivorsan Pharmaceuticals, Inc.] Press Release Biostage, Inc. announced that it has received the NI Engineering Impact Award for Regenerating and Restoring Organ Function Damaged by Disease or Trauma for its groundbreaking Cellframeâ„¢ Technology. [Biostage, Inc.] Press Release | |
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POLICY NEWSNew Leader of NIH’s Research Watchdog Faces Staff Revolt The Office of Research Integrity (ORI) in Rockville, Maryland, which guards against misconduct in biomedical research, usually attracts attention with its findings, not its internal workings. But two years ago, its director, David Wright, quit in a public huff, complaining that ORI was hobbled by a dysfunctional federal bureaucracy. Now, his successor is encountering her own rough waters. [ScienceInsider] Editorial Putin Appoints Church Historian as Science Minister Russian President Vladimir Putin has appointed a church historian as the country’s new science and education minister. The president announced that Olga Vasilyeva would succeed the current science minister, Dmitry Livanov, who will become presidential envoy on trade and economic relations with Ukraine, according to the Russian news agency Interfax. [Nature News] Editorial Obama’s Science Legacy: Betting Big on Biomedical Science Ambitious bids to map the brain and cure cancer have not boosted overall research funding. [Nature News] Editorial US Personalized-Medicine Industry Takes Hit from Supreme Court Rejections for US patents related to personalized medicine have spiked after recent Supreme Court decisions tightened the rules for such claims, an analysis of more than 39,000 patent applications reveals. [Nature News] Editorial Chemistry Group Throws Out Election Results after Fears of Vote Rigging Members of the Society of Biological Inorganic Chemistry are reacting with puzzlement and shock after learning that the results of a recent online leadership election have been thrown out because of voting irregularities—raising concerns over possible manipulation. [ScienceInsider] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) Asia 2016 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Molecular and Cell Biology (Stony Brook University) NEW PhD Student – Molecular and Cell Biology (University of Warsaw) PhD Studentship – Fibrosis (NUI Galway) Postdoctoral Fellow/Scientist – Osteoblast Biology (Michigan State University) Industrial Research Manager – Regenerative Medicine and Tissue Engineering (KU Leuven) PhD Position – Signal Transduction of Cell Migration (Bar-Ilan University) Postdoctoral Position – Angiogenesis, Proteases and Extracellular Matrix (GENYO) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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