Extracellular Matrix News Volume 7.34 | Sep 1 2016

TOP STORY

Glycoproteomics Reveals Decorin Peptides with Anti-Myostatin Activity in Human Atrial Fibrillation

Investigators used proteomics to profile glycoproteins in the human cardiac extracellular matrix (ECM). Atrial specimens were analyzed by mass spectrometry after extraction of ECM proteins and enrichment for glycoproteins or glycopeptides. [Circulation] Abstract

(Ranked by impact factor of the journal)

Bi-Layered Polyurethane – Extracellular Matrix Cardiac Patch Improves Ischemic Ventricular Wall Remodeling in a Rat Model

The objective of this report was to focus on two features by first evaluating the incorporation of a cardiac extracellular matrix component, and second by evaluating the impact of patch anisotropy on the pathological remodeling process initiated by myocardial infarction. [Biomaterials] Abstract

Superabsorbent 3D Scaffold Based on Electrospun Nanofibers for Cartilage Tissue Engineering

Chondrocytes were cultured on 3D scaffold, and their viability and morphology were examined. 3D scaffolds were also subjected to an in vivo cartilage regeneration study on rabbits using an articular cartilage injury model. [ACS Appl Mater Interfaces] Abstract

Oxidized (Non)-Regenerated Cellulose Affects Fundamental Cellular Processes of Wound Healing

Researchers investigated how hemostats such as oxidized regenerated cellulose and oxidized non-regenerated cellulose influence local cellular behavior and contraction of the extracellular matrix. [Sci Rep] Full Article

The Use of a Cartilage Decellularized Matrix Scaffold for the Repair of Osteochondral Defects: The Importance of Long-Term Studies in a Large Animal Model

Scientists investigated the effect of decellularized cartilage-derived matrix scaffolds, by itself and as a composite scaffold with a calcium phosphate base, for the repair of osteochondral defects [Osteoarthritis Cartilage] Abstract

Immunomodulation and Mobilization of Progenitor Cells by Extracellular Matrix Bioscaffolds for Volumetric Muscle Loss Treatment

Extracellular matrix (ECM) implantation promoted perivascular stem cell mobilization, increased presence of neurogenic progenitor cells, and was associated with myotube formation. These cell types were present not only at the periphery of the defect near uninjured muscle, but also in the center of the ECM-filled defect. [Tissue Eng Part A] Abstract

Endothelin-1 Mediated Induction of Extracellular Matrix Genes in Strial Marginal Cells Underlies Strial Pathology in Alport Mice

Investigators explored whether endothelin-1 plays a role in strial pathology. Wild type and Alport mice were treated with the endothelin A receptor antagonist, sitaxentan. The stria vascularis was analyzed for strial capillary basement membrane thickness and for extracellular matrix proteins. [Hear Res] Abstract

Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis

The authors asked how the presence of fibronectin might drive cell-induced tissue morphogenesis, more specifically the formation of gradients in cell density and extracellular matrix composition. [PLoS One] Full Article

Redifferentiation of High-Throughput Generated Fibrochondrocyte Micro-Aggregates: Impact of Low Oxygen Tension

The objective of this study was to produce uniform fibrochondrocyte micro-aggregates with desirable phenotype and tissue homogeneity in large quantities using a simple and reproducible method. Furthermore, the authors investigated if hypoxia could enhance the matrix quality. [Cells Tissues Organs] Full Article

Ovarian Cancer-Peritoneal Cell Interactions Promote Extracellular Matrix Processing

The authors identified several extracellular matrix proteins including, fibronectin, TGFBI, periostin, annexin A2, and PAI-1 that were processed as a result of the ovarian cancer – peritoneal cell interaction. This review focuses on the functional role of these proteins in ovarian cancer metastasis. [Endocr Relat Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Mallinckrodt Receives FDA Fast-Track Designation for Synacthen^® Depot IND Application

Mallinckrodt plc announced the U.S. Food and Drug Administration (FDA) has granted the company’s request for a Fast Track designation for its Investigational New Drug (IND) application for Synacthen^® Depot in the treatment of Duchenne muscular dystrophy. Synacthen Depot is a depot formulation of Synacthen, a synthetic 24 amino acid melanocortin receptor agonist. [Mallinckrodt plc] Press Release

AllCells-Boston to Serve as Company’s Second US-Based Hematologic Tissue Collection Site, Increasing Assurance of Supply and Accelerating Delivery of Fresh Products to Eastern Region and Global Life Science Researchers

AllCells, LLC, announced signing a Clinical Operations lease agreement, and commencing construction of its new clinical collection facility located in metropolitan Boston, MA. The east coast clinic, expected to be operational November 2016, is optimally situated to enhance service to life science researchers located throughout US east coast, Europe, and rest of world. [AllCells, LLC.] Press Release

NEW British Society for Matrix Biology (BSMB) Spring Meeting: Matrix Proteoglycans
April 3-4, 2017
Oxford, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW PhD Position – Tumor Microenvironment in Leukemia (Georg-Speyer-Haus)

Postdoctoral Associate – Molecular and Cell Biology (Stony Brook University)

PhD Student – Molecular and Cell Biology (University of Warsaw)

PhD Studentship – Fibrosis (NUI Galway)

Postdoctoral Fellow/Scientist – Osteoblast Biology (Michigan State University)

Industrial Research Manager – Regenerative Medicine and Tissue Engineering (KU Leuven)

PhD Position – Signal Transduction of Cell Migration (Bar-Ilan University)

Postdoctoral Fellowship – Epigenetic Mechanisms of Decellularized Extracellular Matrix on the Rejuvenation of Adult Stem Cells (West Virginia University)

Postdoctoral Researcher – Enamel Proteins and Biomineralization (University of California, San Francisco)

Postdoctoral Position – Angiogenesis, Proteases and Extracellular Matrix (GENYO)

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