Extracellular Matrix News 7.43 November 3, 2016 | |
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TOP STORYScientists report a microfluidic-based method for encapsulating single cells in an approximately six-micrometre layer of alginate that increases the proportion of cell-containing microgels by a factor of ten, with encapsulation efficiencies over 90%. [Nat Mater] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Structure and Function of a Prostate Cancer Dissemination Permissive Extracellular Matrix The authors investigated the structure and function of an extracellular matrix that facilitates prostate cancer metastasis by comparing orthotopic tumors that frequently metastasize, to poorly metastatic subcutaneous tumors. [Clin Cancer Res] Abstract Impact of Collagen/Heparin Multilayers for Regulating Bone Cellular Functions Layer-by-layer films of type I collagen, the major constituent of bone extracellular matrix, and heparin, a glycosaminoglycan, were assembled on poly(l-lactic acid) substrates to evaluate the impact of the biomacromolecular coating on cell activity. [ACS Appl Mater Interfaces] Abstract Investigators showed that the low-sulfated sHA (sHA1) interacts with fibronectin (FN) and influences fibril assembly. The interaction of FN fibrils with sHA1 and Hep, but not with non-sulfated HA was visualized by immunofluorescent co-staining. [Sci Rep] Full Article Laminin-Guided Highly Efficient Endothelial Commitment from Human Pluripotent Stem Cells Using a short fragment of laminin 411, an extracellular matrix (ECM) predominantly expressed in the vascular endothelial basement membrane, researchers demonstrated that the directed switching of defined ECMs robustly yields highly-purified endothelial progenitor cells without cell sorting from human pluripotent stem cells in an integrin-laminin axis-dependent manner. [Sci Rep] Full Article Gα13 Switch Region 2 Relieves Talin Autoinhibition to Activate αIIbβ3 Integrin Scientists provide evidence that Switch Region 2 of the ubiquitously expressed G protein (G13) directly interacts with talin, relieves its state of autoinhibition, and triggers integrin activation. Biochemical analysis of G13 shows SR2 binds directly to the F3 lobe of talins head domain and competes with the rod domain for binding. [J Biol Chem] Abstract | Full Article Lysyl Hydroxylase 2 Is Secreted By Tumor Cells and Can Modify Collagen in the Extracellular Space It is generally accepted that lysyl hydroxylase 2 (LH2) modifies procollagen α chains on the endoplasmic reticulum prior to the formation of triple helical procollagen molecules. Investigators report that LH2 is also secreted and modifies collagen in the extracellular space. [J Biol Chem] Abstract | Full Article An Integrated Stochastic Model of Matrix-Stiffness-Dependent Filopodial Dynamics Investigators developed a model to relate filopodial focal adhesion dynamics to integrin-mediated Rho signaling kinetics. Results showed that focal adhesion maturation, i.e., focal adhesion links reinforcement and integrin clustering, dominates over filopodial dynamics. [Biophys J] Abstract Moderate Hyperoxia Induces Extracellular Matrix Remodeling by Human Fetal Airway Smooth Muscle Cells Hyperoxia exposure significantly increased collagen I and collagen III deposition, increased pro- and cleaved matrix metalloproteinase 9 (MMP9) activity, and decreased endogenous MMP inhibitor, TIMP1, expression. Hyperoxia-induced change in caveolin-1 expression was assessed as a potential mechanism for the changes in extracellular matrix deposition. [Pediatr Res] Abstract Researchers aimed to use a novel, droplet-based, microfluidic platform to evaluate the prognostic value of a panel of thirty-four genes that regulate the composition of extracellular matrices in colorectal carcinoma. [Biomicrofluidics] Full Article | |
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REVIEWSThe Integrin Adhesome Network at a Glance The authors integrate the consensus adhesome, a set of 60 proteins that have been most commonly identified in isolated integrin adhesion complex (IAC) proteomes, with the literature-curated adhesome, a theoretical network that has been assembled through scholarly analysis of proteins that localize to IACs. [J Cell Sci] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSTELA Bio Announces OviTexâ„¢ Reinforced BioScaffolds Implanted in 100 Hernia Repair Procedures TELA Bio, Inc. announced the company’s OviTexâ„¢ RBSs have been implanted in more than 100 hernia repair procedures since receiving U.S. Food and Drug Administration 510(k) clearance in June 2016. [TELA Bio, Inc. (PR Newswire Association LLC.)] Press Release Philogen SpA Receives Orphan Drug Designation for the Treatment of Soft Tissue Sarcoma Philogen S.p.A. announced that the European Commission has granted Orphan Drug Designation to L19TNF – a non-covalent trimer of tumor necrosis factor fused to an antibody specific to the extra-domain B of fibronectin in single-chain variable fragment format – for the treatment of soft-tissue sarcoma. [Philogen S.p.A. (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSTracker Flags up Failures to Report Clinical Trials An automated tool has trawled through thousands of records on the world’s leading clinical-trials database to reveal which drug firms and academic institutions are failing to publish the results of their trials. The US Department of Health and Human Services announced tougher rules to push the researchers that it funds to publish clinical-trial designs and results. [Nature News] Editorial Publisher Pulls 58 Articles by Iranian Scientists over Authorship Manipulation A tranche of 58 articles authored by 282 Iran-based researchers were retracted by a leading scientific publisher, which said it had found signs that the peer review and publication processes had been compromised. [Nature News] Editorial Young Scientists Ditch Postdocs for Biotech Start-Ups There is a vanguard of young biomedical scientists who have started companies instead of taking the conventional academic path and pursuing postdoctoral studies after their PhDs. Among the factors driving this change are an infusion of money into early-stage biotech investing, the emergence of biotech incubators and the scarcity of academic jobs in science. [Nature News] Editorial Beyond Trump vs Clinton: A Scientist’s Guide to the US Election Choices that voters make will influence other levels of government — and some of these decisions will steer the course of science and science policy. [Nature News] Editorial
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EVENTSNEW Gordon Research Conference: Stem Cells & Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Fellowship – Controlling Cartilage to Bone Transitions (IRCCS Ospedale San Martino) Postdoctoral Fellow – Cancer Research (Luxembourg Institute of Health) Postdoctoral Fellow – Scaffold Design & Drug/Gene Delivery (Nanyang Technological University) Postdoctoral Associate – Molecular Functions of Planar Cell Polarity (Stony Brook University) Postdoctoral Positions – Cellular Information Processing (University of Chicago) Postdoc Position – Molecular Basis of Protein Trafficking (Max Planck Institute of Biochemistry) PhD Position – Tumor Microenvironment in Leukemia (Georg-Speyer-Haus) Postdoctoral Fellow/Scientist – Osteoblast Biology (Michigan State University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Extracellular Matrix News Volume 7.43 | Nov 3 2016