Extracellular Matrix News 7.44 November 10, 2016 | |
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TOP STORYInvestigators showed that myogenic progenitor cells (MPCs) interact with interstitial fibrogenic cells to ensure proper extracellular matrix (ECM) deposition and optimal muscle remodeling in response to hypertrophic stimuli. MPC-dependent ECM remodeling during the first week of a growth stimulus is sufficient to ensure long-term myofiber hypertrophy. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Using genetic deletion and time-lapse imaging, researchers showed that retinal astrocytes require neuronal-derived PDGF as a chemoattractive cue and the retinal basement membrane as a migratory substrate. Genetic ablation of heparan sulfates does not produce the same defects as glycosaminoglycan null mutants. [Cell Reports] Full Article | Graphical Abstract The authors showed that laminin α2 in the basement membrane (BM) serves as the crucial regulator in this axis as laminin α2, likely its 80 kDa fragment from the C terminus, was found to be transported across the seminiferous epithelium at stages VIII-IX of the epithelial cycle, from the BM to the luminal edge of the tubule, possibly being used to modulate apical ectoplasmic specialization restructuring at these stages. [FASEB J] Abstract The authors’ results showed that external mechanical stretching significantly increased COL1A1, TGF-β1 and eIF6 expression as well as dermal fibroblasts proliferation, both in vitro and in vivo. [Sci Rep] Full Article Researchers non-destructively quantified collagen organization, content, and cross-linking within decellularized healthy and infarcted myocardium using second harmonic generation and two photon excited autofluorescence. [Sci Rep] Full Article The Role of α-Smooth Muscle Actin in Fibroblast-Mediated Matrix Contraction and Remodeling Investigators explored the effects of the matrix environment in modulating cardiac fibroblast phenotype, and they investigated the role of α-smooth muscle actin in fibroblast function using loss- and gain-of-function approaches. [Biochim Biophys Acta] Abstract The authors aimed to study the arterial extracellular matrix graft patency in vivo, and possibly improve that patency by graft pre-endothelialization with the recipient porcine autologous cells using their previously reported custom designed dynamic-perfusion bioreactor system. [Tissue Eng Part A] Abstract The objectives of this study were to develop a novel injectable calcium phosphate cement (CPC) construct containing hydrogel fibers encapsulating cells for bone engineering, and to investigate and compare cell viability, proliferation and osteogenic differentiation of human induced pluripotent stem cells- mesenchymal stem cells (MSCs), human embryonic stem cells-MSCs and human umbilical cord MSCs in injectable CPC. [Biomed Mater] Abstract Salbutamol, an agonist of β2-AR, promoted cell proliferation, albumin secretion and urea synthesis in the recellularized liver. Cytokines were screened in isoprenaline/salbutamol-treated recellularized liver, and the expression of IL-6 was significantly increased. Isoprenaline or salbutamol especially promoted the expression of Stat 3 and phosphorylated Stat 3, contributing to the activation of IL-6/Stat 3 signaling in promoting hepatocyte proliferation and recellularized liver function. [Biomed Mater] Abstract | |
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REVIEWSThe Challenge in Using Mesenchymal Stromal Cells for Recellularization of Decellularized Cartilage The authors survey the present state of preparing decellularized cartilage extracellular matrices-derived scaffolds or composites for reconstruction of different cartilage types and of reseeding it particularly with mesenchymal stromal cells. [Stem Cell Rev] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSSymic Bio announced the completion of enrollment for its Phase I/IIa MODIFY-OA clinical trial of SB-061 in the treatment of osteoarthritis of the knee. Top-line results from the trial are expected to be announced in the first half of 2017. [Symic Bio] Press Release Soluble Systems, LLC announces the Palmetto LCD now includes coverage of TheraSkin® over partial and/or full-thickness ulcers involving tendon, muscle, joint capsule or exhibiting exposed bone or sinus tracts, with a clean granular base. [Soluble Systems, LLC. (PR Newswire Association LLC.)] Press Release CollPlant Signs Exclusive Distribution Agreement with Arthrex for Vergenix™STR CollPlant Ltd. announced that it has signed an exclusive distribution agreement with Arthrex for Vergenix™STR for the treatment of tendinopathy. [CollPlant Ltd.] Press Release | |
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POLICY NEWSDonald Trump’s US Election Win Stuns Scientists Republican businessman and reality-television star Donald Trump will be the United States’ next president. Although science played only a bit part in this year’s dramatic, hard-fought campaign, many researchers expressed fear and disbelief as Trump defeated former secretary of state Hillary Clinton. [Nature News] Press Release Big Brain Projects Urged to Aid Public Health Major brain-mapping projects have multiplied in recent years, as neuroscientists develop new technologies to decipher how the brain works. These initiatives focus on understanding the brain, but the World Health Organization wants to ensure that they work to translate their early discoveries and technological advances into tests and treatments for brain disorders. [Nature News] Editorial Hard Work, Little Reward: Nature Readers Reveal Working Hours and Research Challenges A poll answered by thousands of Nature readers suggests that nearly two-thirds have considered quitting research, and that almost 40% work more than 60 hours in a week. The fight for funding is the greatest challenge facing early-career scientists, readers said. [Nature] Editorial Twitterstorm Shows Why Scientific Evidence Matters Grammar and Twitter rarely sit happily, so it would be churlish to point out that when the Welsh MP Glyn Davies tweeted at the weekend: “Nothing more irritating than academics rubbishing the efforts of those operating at the sharp end, without facing up to the hard decisions”, he was inadvertently complaining that people at the sharp end (himself included presumably) do not confront hard decisions. [Nature] Editorial
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EVENTSNEW 19th International Conference on Clinical Application of Adult Stem Cells Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPhD Fellowship – Controlling Cartilage to Bone Transitions (IRCCS Ospedale San Martino) Postdoctoral Fellow – Cancer Research (Luxembourg Institute of Health) Postdoctoral Fellow – Scaffold Design & Drug/Gene Delivery (Nanyang Technological University) Postdoctoral Associate – Molecular Functions of Planar Cell Polarity (Stony Brook University) Postdoctoral Positions – Cellular Information Processing (University of Chicago) Postdoc Position – Molecular Basis of Protein Trafficking (Max Planck Institute of Biochemistry) PhD Position – Tumor Microenvironment in Leukemia (Georg-Speyer-Haus) Postdoctoral Fellow/Scientist – Osteoblast Biology (Michigan State University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Extracellular Matrix News Volume 7.44 | Nov 10 2016