Extracellular Matrix News 8.36 September 14, 2017 | |
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TOP STORYCystic cavities were bridged by fibronectin-rich extracellular matrix. The fibrotic extracellular matrix remodeling was mediated by matrix metalloproteinase-9 expressed in macrophages within the fibrotic extracellular matrix. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators isolated neonatal cardiac cells and recellularized into atrial ECM, referred here has engineered atria. Remarkably, miR-199a-3p mediated the enrichment of cardiomyocyte and sinus nodal cell population, and enhanced electrocardiographic signal activity of sinus nodal cells in the engineered atria. [Biomaterials] Abstract Investigators tested the hypothesis that extracellular matrix (ECM) influences the N-methyl-D-aspartate subtype of ionotropic glutamate receptor subunit composition in dissociated neuronal cultures. Experimental removal of ECM using hyaluronidase induced an increase in surface expression of GluN2B. [Sci Rep] Full Article Characterization of Dermal Myofibroblast Differentiation in Pseudoxanthoma Elasticum Scientists revealed that human dermal pseudoxanthoma elasticum fibroblasts possess exaggerated migration capability in wound healing and attenuated myofibroblast contractility in comparison to controls. [Exp Cell Res] Abstract Researchers describe the production, characterization, and use of an injectable, peripheral nerve-specific extracellular matrix-based hydrogel for promoting modulation of the local macrophage and Schwann cell responses at the site of nerve repair in a rodent model of sciatic nerve injury. [J Biomed Mater Res A] Abstract Late-passage ECM-expanded periodontal ligament cells exhibited a much higher proliferation index and lower levels of reactive oxygen species, confirmed by the increased expression of pluripotent markers and enhanced osteogenic capacity. [J Biomed Mater Res A] Abstract SIP-SII inhibited p38/MAPK and PI3K/Akt/mTOR signaling pathways in SKOV-3 cells significantly. What is more, SIP-SII showed amplified inhibitory activity on migration, invasion, and MMP-2 expression in combination with p38-specific inhibitor, PI3K-specific inhibitor or mTOR-specific inhibitor in SKOV-3 cells. [Int J Biol Macromol] Abstract Scientists showed that kruppel-like factor 4 (KLF4) is expressed in the epiphyseal growth plate and articular chondrocytes. Most articular chondrocytes expressed KLF4 in embryos but it localized only in a subset of superficial zone cells in postnatal mice. [Cell Tissue Res] Abstract In a model system of mammary COMMA-1D cells, exogenously and endogenously expressed milk fat globule-EGF factor 8 (MFG-E8) was deposited in the ECM with membranous particles dependently on the phosphatidylserine-binding motifs in the discoidin domains that were essential for association ability to extracellular vesicles. [Genes Cells] Abstract | |
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REVIEWSThe authors provide an overview of recent developments in bone tissue engineering focusing on flavonoids and their potent biological properties that enhance bone health. [Int J Biol Macromol] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSTelos Partners, LLC has been selected by Acera Surgical to lead its Restrata™ wound matrix study titled: “Clinical Outcomes after Treatment with Restrata™ in Diabetic Foot Ulcers: A Case Series of Initial Effectiveness and Safety Measures.” [Telos Partners, LLC] Press Release Humacyte Completes Patient Enrollment for Phase III Clinical Trial of Human Acellular Vessel Humacyte announced that it has completed enrollment of 350 evaluable subjects for its Phase III HUMANITY® study of HUMACYL®, Humacyte’s investigational human acellular vessel. [Humacyte, Inc.] Press Release Young Investigator Award for Dr Elena Rainero Dr Elena Rainero has been awarded the British Society for Matrix Biology Young Investigator Award for 2017. The prestigious award, made possible following a bequest from the estate of Professor John Scott, is presented annually to an early career researcher who has made a significant contribution to matrix biology and has excelled in the early stages of their research career. [The University of Sheffield] Press Release | |
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POLICY NEWSAfter Uproar, U.K. Parliament’s Science Committee Now Has a Female Member The House of Commons Science and Technology Committee tweeted that it was “pleased to announced our membership has been confirmed.” Parliamentary committees had been dissolved after the recent U.K. election, and now the panel was rolling out its new contingent of lawmakers. The only problem: All eight of the mostly smiling faces belonged to men. [ScienceInsider] Press Release UK Gender-Equality Scheme Spreads across the World A program that grades UK universities on gender equality in science is going global. Versions of the rating scheme have started up in the past two years in Australia and Ireland, and a small-scale pilot begins next month in the United States. [Nature News] Editorial
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EVENTSNEW American Society for Cell Biology (ASCB)-European Molecular Biology Organization (EMBO) 2017 Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Research Fellowship – Kidney Disease (Vanderbilt University Medical Center) Faculty Position – Regenerative Biology (Northwestern University) Postdoctoral Research Scientist – Cancer Research (Cancer Research UK Beatson Institute) Postdoctoral Researchers – Cancer Metastasis and Drug Resistance (Tufts University) Postdoctoral Fellow – Tumor Microenvironment and Cancer Stem Cells (Duke University Medical Center) Tenure Track Position – Stem Cell Biology (MD Anderson Cancer Center) Assistant Professor – Stem Cell and Regenerative Biology (Harvard University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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