Extracellular Matrix News 8.41 October 19, 2017 | |
| |
TOP STORYFibroblasts cultured on gelatin-coated surfaces were maintained in the presence of ascorbic acid to strengthen matrix deposition over one–three weeks. The resulting fibrillar cell-derived matrices were denuded of cells, and other cells were subsequently cultured on them, after which their behavior was monitored. [Nat Protoc] Full Article | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Knockdown of mutated in colorectal cancer (MCC) in HCT116 colon cancer cells caused a reduction in E-cadherin protein level, which is a hallmark of epithelial–mesenchymal transition in cancer, and consequently diminished the E-cadherin/β-catenin complex. [Oncogene] Full Article In primary hepatic stellate cells from normal and fibrotic rat liver, researchers demonstrated that myocardin, a canonical serum response factor cofactor, was upregulated in hepatic myofibroblasts and differentially regulates smooth muscle (SM) α-actin, γ-actin, and β-actins through activation of an ATTA box in the SM α-actin and a CCAAT box in γ-actin and β-actin promoters, respectively. [Lab Invest] Full Article Using protrusion-isolation schemes and RNA-Seq, scientists found that RNAs localized in protrusions of migrating fibroblasts can be distinguished in two groups, which were differentially enriched in distinct types of protrusions, and were additionally differentially dependent on adenomatous polyposis coli. [Sci Rep] Full Article Investigators found that intravenous injection of exosomes secreted by human adipose mesenchymal stem cells decreased the size of scars and increased the ratio of collagen III to collagen I in murine incisional wounds. Exosome treatment also prevented the differentiation of fibroblasts into myofibroblasts and increased the ratio of transforming growth factor (TGF)-β3 to TGF-β1 in vivo. [Sci Rep] Full Article A randomized, controlled, multicenter clinical trial was conducted to evaluate the efficacy of dehydrated human amnion/chorion membrane allograft as an adjunct to multilayer compression therapy for the treatment of non-healing full-thickness venous leg ulcers. [Int Wound J] Full Article | Press Release LOX-1 Is Involved in IL-1β Production and Extracellular Matrix Breakdown in Dental Peri-Implantitis The authors explored whether lectin-type oxidized LDL receptor 1 (LOX-1), interleukin 1 beta (IL-1β), matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) were involved in the nosogenesis of human dental peri-implantitis and determine the role of LOX-1 in IL-1β, MMP2 and MMP9 production in response to Porphyromonas gingivalis. [Int Immunopharmacol] Abstract Scientists have integrated two electrospun polycaprolactone matrices with different fiber diameters in one chip. They then studied the 3D migration of MDA-MB-231 breast cancer cells into the matrices under the influence of a chemotactic gradient. [Biomed Microdevices] Abstract Researchers performed immunofluorescence analysis of components of stable, mature extracellular matrix produced by primary human renal proximal tubular epithelial cells and renal fibroblasts in response to cytokine stimulation. [Biol Open] Abstract | |
| |
REVIEWSFrom Supramolecular Polymers to Multi-Component Biomaterials Scientists show the translation of one-dimensional supramolecular polymers into multi-component functional biomaterials for regenerative medicine applications. [Chem Soc Rev] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
| |
INDUSTRY NEWSMiMedx Group, Inc. announced that the company has been notified by the FDA that its Investigational New Drug Phase IIB clinical study for osteoarthritis of the knee may proceed. [MiMedx Group, Inc.] Press Release Anika Therapeutics, Inc. announced that regulatory authorities in Australia granted approval to MONOVISC®, Anika’s single injection viscosupplement for the treatment of pain associated with osteoarthritis of all synovial joints, including the hip and knee. [Anika Therapeutics, Inc.] Press Release | |
| |
POLICY NEWSRand Paul Takes a Poke at U.S. Peer Review Panels Senate Republicans have launched a new attack on peer review by proposing changes to how the U.S. government funds basic research. [ScienceInsider] Editorial Efforts to Save Leading Hungarian University Hit Hurdle The threatened Central European University in Budapest has been dealt a blow in its efforts to avert possible closure in Hungary. The country’s parliament voted to postpone, for a year, a decision that would allow the university to keep operating there. [Nature News] Editorial New Definitions of Scientific Units Are on the Horizon Revamped definitions of scientific units are on their way. In the biggest overhaul of the international system of units since its inception in 1960, a committee is set to redefine four basic units — the ampere, the kilogram, the kelvin and the mole — using relationships to fundamental constants, rather than abstract or arbitrary definitions. [Nature News] Editorial Top Chinese University to Consider Social-Media Posts in Researcher Evaluations One of China’s most prestigious universities plans to give some articles in newspapers and posts on major social-media outlets the same weight as peer-reviewed publications when it evaluates researchers. [Nature News] Editorial
| |
EVENTSNEW Gordon Research Conferences: Chromatin Structure & Function Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Assistant Professor – Stem Cell And Regenerative Biology (Columbia University) NEW Postdoctoral Fellow – Inflammatory Bowel Disease (Emory University) Postdoctoral Position – Bioengineering and Regenerative Medicine (Maastricht University) Postdoctoral Positions – Neuroscience (Harvard Medical School) Assistant or Associate Professor – Biomedical Engineering (University of British Columbia) Postdoctoral Position – Wound Healing (University of Connecticut Health Center) Postdoctoral Research Fellowship – Kidney Disease (Vanderbilt University Medical Center) Postdoctoral Researchers – Cancer Metastasis and Drug Resistance (Tufts University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Extracellular Matrix News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|