Extracellular Matrix News Volume 9.10 | Mar 15 2018

TOP STORY

Basal Lamina Remodeling at the Skeletal Muscle Stem Cell Niche Mediates Stem Cell Self-Renewal

Researchers showed that upon activation, skeletal muscle stem cells (satellite cells) induced local remodeling of the ECM and the deposition of laminin-α1 and laminin-α5 into the basal lamina of the satellite cell niche. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Inhibition of Osteoclastogenesis by Stem Cell-Derived Extracellular Matrix through Modulating the Intracellular Reactive Oxygen Species

ECM was deposited by mesenchymal stem cells and, after decellularization, the effect of ECM on osteoclastogenesis of bone marrow monocytes was investigated in comparison to standard tissue culture polystyrene. [Acta Biomater] Abstract

MTSS1 and SCAMP1 Cooperate to Prevent Invasion in Breast Cancer

Researchers found that the secretory carrier-associated membrane protein 1 (SCAMP1), a molecule involved in post-Golgi recycling pathways and in endosome cell membrane recycling, enhances metastasis suppressor protein 1 (Mtss1) anti-invasive function in HER2⁺/ER⁻/PR⁻ breast cancer, by promoting its protein trafficking leading to elevated levels of RAC1-GTP and increased cell-cell adhesions. [Cell Death Dis] Full Article

The Mode and Dynamics of Glioblastoma Cell Invasion into a Decellularized Tissue-Derived Extracellular Matrix-Based Three-Dimensional Tumor Model

Scientists propose biomimetic glioblastoma multiforme-specific ECM microenvironment for studying mode and dynamics of glioblastoma cell invasion. Using tissue decellularization process, they constructed a patient tissue-derived ECM-based three-dimensional in vitro model. [Sci Rep] Full Article

Biological and Mechanical Interplay at the Macro- and Microscales Modulates the Cell-Niche Fate

Model monocultures and 1:1 co-cultures on the porcine cardiac ECM of human umbilical vein endothelial cells and human mesenchymal stem cells were mechano-biologically characterized using macro-, and micro- mechanical testing, histology, scanning electron microscopy and molecular biology aspects using quantitiative realtime-PCR arrays. [Sci Rep] Full Article

Extracellular Matrix Proteins as Diagnostic Markers of Breast Carcinoma

Scientists tested the hypothesis that abnormal production of ECM components leads to blood-released ECM molecules representing tumor circulating biomarkers. Production and release of ECM molecules were evaluated in normal human dermal fibroblasts treated with conditioned media from three breast carcinoma cell lines. [J Cell Physiol] Abstract

Cyclopamine Treatment Disrupts Extracellular Matrix and Alleviates Solid Stress to Improve Nanomedicine Delivery for Pancreatic Cancer

Cyclopamine, a special inhibitor of the hedgehog signaling pathway which contributes a lot to ECM formation of pancreatic ductal adenocarcinoma (PDA), was exploited to alleviate solid stress and improve nanomedicine delivery to PDA. [J Drug Target] Abstract

Dermal Fibroblasts Can Activate Matrix Metalloproteinase-1 Independent of Keratinocytes via Plasmin in a 3D Collagen Model

Investigators constructed a 3D model of the dermis using collagen-embedded fibroblasts with or without ultraviolet (UV)-A exposure to mimic photoaging in the dermis. Collagen lattices embedded with UV-A irradiated fibroblasts miniaturized and collagen was degraded to a greater extent than collagen lattices embedded with non-irradiated fibroblasts. [Exp Dermatol] Abstract

Abnormal Extracellular Matrix Remodeling in the Cervix of Pregnant Relaxin-Deficient Mice Is Not Associated with Reduced Matrix Metalloproteinase Expression or Activity

Researchers hypothesized that abnormal collagen remodeling in the cervix of pregnant relaxin-deficient mice is due to excessive collagen and decreased matrix metalloproteinases and estrogen receptors. [Reprod Fertil Dev] Abstract

Extracellular Matrix in Lung Development, Homeostasis and Disease

The authors assessed the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. [Matrix Biol] Abstract

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

iBio Selects Lead Candidate for Its Fibrosis Therapeutics Program

iBio, Inc. announced that it had selected an E4-Fc fusion protein as its lead candidate for further development of a drug against fibrotic diseases, including systemic sclerosis and idiopathic pulmonary fibrosis. [iBio, Inc.] Press Release

AmnioFix^® Injectable Granted Regenerative Medicine Advanced Therapy (RMAT) Designation by the FDA for the Treatment of Osteoarthritis of the Knee

MiMedx Group, Inc. announced that the FDA has granted MiMedx’s micronized amniotic tissue, AmnioFix^® Injectable, the RMAT designation for use in the treatment of osteoarthritis of the knee. [MiMedx Group, Inc.] Press Release

Scientists Beware: The Price Is High, the Payoff Uncertain at Glossy Publications Aimed at Europe’s Decision-Makers

Van der Heyden isn’t the only European researcher to get a hard sell from Pan European Networks, a six-year-old publishing company with offices in Congleton, U.K., and Brussels that promises to provide opportunities for “leading figures from across Europe” to get attention for their work or ideas. Many other scientists had similar experiences, Van der Heyden discovered when he started poking around on blogs and Twitter, including the promise of attention from decision-makers and the warning about the imminent board meeting. [ScienceInsider] Editorial

‘Right-to-Try’ Bill Rejected by House, in Major Blow to GOP Efforts

In a major blow to the effort to pass a federal “right-to-try” law, House Republicans failed to muster the votes to pass a key compromise measure. [STAT News] Editorial

Springer Nature and VSNU Renew Agreement on Open Access Publishing

Springer Nature and the Association of Universities in the Netherlands (VSNU) have renewed their agreement to secure open access publishing for Dutch universities up to 2021. [The Association of Universities in the Netherlands] Editorial

Science ‘Champion’ Dan Lipinski Faces Tough Race in Illinois Primary

Representative Daniel Lipinski—an anti-abortion Democrat who voted against the Affordable Care Act and who only recently has embraced a path to citizenship for undocumented immigrants—knows that he’s out of step with progressives on many social issues. Lipinski will find out whether voters in Illinois’s third congressional district on Chicago’s southwest side feel there’s still room for him in the Democratic Party. [ScienceInsider] Editorial

NEW Canadian Connective Tissue Society (CCTC) 2018 24^th Annual Meeting
May 23-25, 2018
Toronto, Ontario, Canada

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Positions – Bioengineering (George Washington University)

NEW Faculty Position – Stem Cell Biology and Regenerative Medicine (University of Illinois at Chicago)

Postdoctoral Associate – Biomedical Engineering (University of Minnesota)

Principal Scientist – Regenerative Medicine (Boehringer Ingelheim)

Lectureship – Stem Cell Biology (University of Edinburgh)

Senior Stem Cell Scientist – 3D Tissue Engineering (VitroLabs Inc)

Postdoctoral Position – Spinal Cord Injury (Nanyang Technological University)

Executive Director – Bioengineering and Bioscience (Georgia Institute of Technology)

Postdoctoral Fellowships – Nanomedicine and Cell Engineering (The Institute for Bioengineering of Catalonia)

Scientist – Stem Cell and Regenerative Biology (Moderna Therapeutics)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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