Extracellular Matrix News 9.18 May 10, 2018 | |
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TOP STORYSpecific oxidation-dependent modification of extracellular matrix, aided by neutrophils, promoted subsequent αMβ2– and αDβ2-mediated migration/retention of macrophages during inflammation. [Blood] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators identified heparan sulfate proteoglycan proteins, including collagen XVIII and agrin, as important regulators of enteric neural crest-derived cell (ENCDC) development. ENCDCs governed their own migration by actively remodeling their microenvironment through secretion of ECM proteins. [Development] Abstract Scientists showed high-temperature requirement protein A1 (HTRA1) protein level is increased in high-risk retinal pigment epithelium cells along with several extracellular matrix proteins, including known HTRA1 cleavage targets LTBP-1 and clusterin. [Aging Cell] Abstract | Full Article From 122 altered proteins, protein-protein interactions network analysis revealed that downregulated heat shock protein 90 and lamin A/C served as the central nodes of protein-protein interactions involving in several crucial biological functions, including cytoskeleton organization, extracellular matrix organization, and tissue development. [Cell Death Dis] Full Article The authors demonstrated a scaffold made of silk fibroin (SF) which exhibits compression modulus comparable to natural cancellous bone while retaining the appropriate porosities and interconnected pore architecture. The scaffolds also exhibited high resistance to in vitro proteolytic degradation due to the dominant beta sheet conformation of the SF protein. [Sci Rep] Full Article Researchers investigated the role of CTGF in TGF-β-induced extracellular matrix production and myofibroblast transdifferentiation in Graves’ orbital fibroblasts. By Western blot analysis, they demonstrated that TGF-β1 induced the expression of CTGF, fibronectin, and alpha-smooth muscle actin in Graves’ orbital fibroblasts. [Sci Rep] Full Article An Extracellular Matrix-Mimicking Hydrogel for Full Thickness Wound Healing in Diabetic Mice Under typical 2D cell culture conditions, murine 3T3 fibroblasts adhered to, and proliferated on top of the hyaluronan-gelatin (HA-GEL) substrates, which demonstrated that HA-GEL provides a favorable microenvironment for cell survival, adhesion, and proliferation. [Macromol Biosci] Abstract Scientists demonstrated that SND p102 is a key regulator of angiotensin II type 1 receptor (AT1R)-mediating ECM synthesis and cell proliferation in mesangial cells. [Acta Pharmacol Sin] Abstract Chitosan/Gelatin Scaffolds Support Bone Regeneration Histological data following implantation of a chitosan/gelatin scaffold into a mouse femur demonstrated that the scaffolds support the formation of extracellular matrix, while fibroblasts surrounding the porous scaffold produce collagen with minimal inflammatory reaction. [J Mater Sci Mater Med] Abstract | |
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REVIEWSEngineering Musculoskeletal Tissue Interfaces The authors focus on recent advancements in strategies for musculoskeletal interface engineering using different biomaterial-based platforms and surface modification techniques. [Front Mater] Full Article Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSGenome BC Invests $1 million in Funding to Top Canadian 3D Bioprinting Company Aspect Biosystems Genome BC announced $1 million in funding to Aspect Biosystems, a privately held biotechnology company focused on commercializing cutting-edge 3D bioprinting technologies. Aspect’s Lab-on-a-Printer™ 3D bioprinting platform technology enables the rapid creation of functional living tissues. [Aspect Biosystems Ltd.] Press Release £4M Bid to Find Therapies That Prompt Tissues to Repair Stem cell scientists are to join forces with doctors to investigate methods of promoting tissue repair in the liver, lungs and joints. The £4 million project seeks to better understand the environment in which stem cells grow in the body, known as the niche. [The University of Edinburgh] Press Release SwRI Joins Advanced Regenerative Manufacturing Institute Consortium Southwest Research Institute has joined the Advanced Regenerative Manufacturing Institute (ARMI) to help advance large-scale manufacturing of engineered tissues and related technology. ARMI is a consortium of nearly 100 organizations comprised of organizations in industry, government, academia and nonprofit sectors to develop next-generation manufacturing processes and technologies for cells, tissues and organs. [Southwest Research Institute] Press Release | |
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POLICY NEWSFDA Seeks Permanent Injunctions against Two Stem Cell Clinics The FDA, in two complaints filed in federal court, is seeking permanent injunctions to stop two stem cell clinics from marketing stem cell products without FDA approval and for significant deviations from current good manufacturing practice requirements. [U.S. Food and Drug Administration] Press Release Hungarian Scientists Are on Edge As Country Is Poised to Force Out Top University In early April, several days after Viktor Orbán secured his third consecutive term—and fourth overall—as Hungarian prime minister with a landslide victory for his conservative party, the pro-government paper Figyelő; published a list of more than 200 people it called “mercenaries” of George Soros, the American-Hungarian billionaire philanthropist. The list included investigative journalists and human rights advocates—and 30 academics from the Soros-founded, Budapest-based Central European University. [ScienceInsider] Editorial Release of Three Americans by North Korea Bolsters Hopes for Academic Diplomacy The release of three Americans by North Korea is being welcomed in the United States. Leaders of the Pyongyang University of Science and Technology in North Korea also see the move as good news, and are hoping it might ultimately lead to the end of a travel ban that has prevented its U.S. instructors from teaching classes. [ScienceInsider] Editorial
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EVENTSNEW ETH Summer School: New Frontiers in Extracellular Matrix Research: From Regeneration to Immunology, Mechanics and Soft Robotics NEW Federation of American Societies for Experimental Biology (FASEB): Cross-Translational Research in Fibrosis across Organs Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Stem Cells & Regenerative Biology (Helmholtz Zentrum München) NEW Postdoctoral Fellow – Bioengineering (Harvard University) Postdoctoral Fellows – Molecular and Translational Cancer Biology (Thomas Jefferson University) Postdoctoral Position – Bioengineering Cell Fate and Morphogenesis in Organoids (KU Leuven) Postdoctoral Fellow – Wound Signaling (Memorial Sloan Kettering Cancer Center) Assistant Professor – Regenerative Medicine (University of California, San Diego) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Postdoctoral Position – Spinal Cord Injury (Nanyang Technological University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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