Extracellular Matrix News 9.20 May 24, 2018 | |
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TOP STORYNew Biomaterial Helps Regrow Brain Tissue after Stroke in Mice In a first-of-its-kind finding, a new stroke-healing gel helped regrow neurons and blood vessels in mice with stroke-damaged brains, researchers report. [Press release from Duke University discussing online prepublication in Nature Materials] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)A Size Switchable Nanoplatform for Targeting the Tumor Microenvironment and Deep Tumor Penetration Scientists constructed a novel size-adjustable nanoplatform for efficient drug delivery into solid tumors. The smart size-switchable nanoplatform was prepared by conjugating small dendrigraft poly-L-lysine to poly(ethylene glycol)-poly(caprolactone) micelles via a matrix metalloproteinase 2-sensitive peptide. [Nanoscale] Abstract The authors investigated the laminin expression in human developing and adult retina, showing laminin α1, α5, β1, β2 and γ1 to be predominantly expressed in Bruch’s membrane and the inner limiting membrane. Blocking of laminin γ3 function in retinal organoids resulted in the disruption of laminar organization and synapse formation, the loss of photoreceptor organization and retinal ganglion cells. [Cell Death Dis] Full Article Proteomic Characterization of the Extracellular Matrix of Human Uterine Fibroids Investigators performed systematic ECM enrichment procedure and comparative proteomic analyses to profile the ECM composition of genetically annotated different size fibroids and adjacent normal myometrium. [Endocrinology] Abstract Researchers hypothesized that a change in extrinsic osmotic pressure would alter the production of extracellular matrices by zone-specific chondrocytes. They incubated spheroidal cartilage organoids, formed by specific longitudinal depth zone-derived chondrocytes, under different levels of osmotic pressure. [Int J Mol Sci] Full Article Hyaluronic Acid Influence on Normal and Osteoarthritic Tissue-Engineered Cartilage Scientists identified gene expression profiles associated with hyaluronic acid treatment of normal and osteoarthritis-like tissue-engineered cartilage. To document ECM formation, glycosaminoglycans were stained with Safranin-O and cartilage-specific type II collagen was detected immunohistochemically. [Int J Mol Sci] Full Article Investigators showed that HIV-associated activation of mitogen-activated protein kinase (MAPK) leads to upregulation of transcription factor NF-κB and matrix metalloproteinase-9. This induces the disruption of tight and adherens junctions, increasing HSV-1 cell-to-cell spread. [J Gen Virol] Full Article Extracellular Matrix Protein DMP1 Suppresses Osteogenic Differentiation of Mesenchymal Stem Cells Dentin matrix protein 1 (DMP1) is an ECM protein enriched in bone tissue and terminal cells, which is well-known in promoting osteoblast and osteocyte maturation, and facilitates mineralization. DMP1 conditional knockout mice model under Prx1cre was generated to explore whether DMP1 regulates mesenchymal stem cells osteogenic differentiation. [Biochem Biophys Res Commun] Abstract Regulation of Interferon Signaling and HCV-RNA Replication by Extracellular Matrix The native HuH-7 human hepatoma cell line and HuH-7 cells were stably transfected with full-length chronic hepatitis C virus (HCV)-RNA fused with Renilla luciferase (OR6 cells) were cultured on ECM-coated dishes or non-coated plastic dishes (NDs), and treated with human interferon (IFN)-α. After IFN-α treatment, the amount of HCV-RNA and viral protein produced by OR6 cells cultured on coated dishes was higher than that produced by cells cultured on NDs. [Int J Mol Med] Abstract | Download Full Srticle | |
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REVIEWSThe authors discuss the current therapeutic strategies to modulate ECM components to improve islet engraftment. [Curr Diab Rep] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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SCIENCE NEWSSpinalCyte Announces Presentations at the American Society of Gene & Cell Therapy SpinalCyte, LLC announced poster presentations highlighting a recent double-blind, placebo controlled human trial of CybroCell™ HDFs to treat degenerative disc disease along with Superior Immune Modulation for Arthritis and Treatment of Acute Liver Failure. [Press release from SpinalCyte, LLC. discussing research presented at the 21st Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), Chicago] Press Release Prometic Presents New Clinical Data on PBI-4050 for the Treatment of Idiopathic Pulmonary Fibrosis Prometic Life Sciences Inc. announced an oral presentation of new clinical data assessing the effect of its lead small molecule candidate, PBI-4050, on blood biomarkers for the treatment of idiopathic pulmonary fibrosis. [Press release from Prometic Life Sciences Inc. discussing research presented at the American Thoracic Society (ATS) 2018 International Conference] Press Release | |
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INDUSTRY NEWSLeonhardt Ventures and Axolotl Biologix announced a strategic partnership to explore therapeutic and commercial opportunities of combining Leonhardt’s bioelectric stimulator + micro pump + mixed stem cell-based compositions for organ regeneration with the Axolotl Biologix lineup of amniotic-derived fluid products. [Leonhardt Vineyards LLC.] Press Release Oncternal Therapeutics, Inc., a clinical-stage biotechnology company developing first-in-class therapies for rare and common malignancies, announced a clinical supply arrangement with Pharmacyclics through which Pharmacyclics supplies ibrutinib, a small molecule inhibitor of Bruton’s tyrosine kinase, for a Phase Ib/II clinical trial combining Oncternal’s novel monoclonal antibody, cirmtuzumab, and ibrutinib in patients with mantle cell lymphoma and chronic lymphocytic leukemia /small lymphocytic leukemia . [Oncternal Therapeutics, Inc.] Press Release | |
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POLICY NEWSItaly’s New Prime Minister Defended Discredited Stem Cell Therapy The electoral victory of two populist parties in March had Italian scientists worried that a new era of antiscientific policies might be around the corner—and yesterday’s appointment of Giuseppe Conte as the country’s new prime minister is making some even more nervous. [ScienceInsider] Editorial Swedish Court Blocks New Home for Nobel Foundation A Swedish court has blocked construction of a controversial new Nobel Center planned for central Stockholm’s waterfront. The eight-story, brass-clad structure is expected to serve as a hub for the Nobel Foundation’s activities, including the annual December award ceremonies for the world’s most prestigious science prizes. [ScienceInsider] Editorial Scientist Who Received Millions from NIH Leaves Alabama Posts A professor who received about $5 million in grants from the National Institutes of Health left his posts at the University of Alabama, Birmingham (UAB), and Birmingham VA Medical Center last year after an investigation found evidence of image manipulation in 20 of his papers, Retraction Watch has learned. [The Scientist] Editorial
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EVENTSNEW The New York Stem Cell Foundation (NYSCF) Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Assistant, Associate or Full Professor – Regenerative Medicine (University of San Diego) Full Professor – Biomedical Sciences (Dublin City University) Postdoctoral Position – Stem Cells & Regenerative Biology (Helmholtz Zentrum München) Postdoctoral Fellow – Bioengineering (Harvard University) Postdoctoral Fellows – Molecular and Translational Cancer Biology (Thomas Jefferson University) Postdoctoral Position – Bioengineering Cell Fate and Morphogenesis in Organoids (KU Leuven) Postdoctoral Fellow – Wound Signaling (Memorial Sloan Kettering Cancer Center) Assistant Professor – Regenerative Medicine (University of California, San Diego) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Postdoctoral Position – Spinal Cord Injury (Nanyang Technological University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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