Extracellular Matrix News 9.25 June 28, 2018 | |
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TOP STORYPROX1 Is a Transcriptional Regulator of MMP14 Researchers showed that PROX1 suppresses the transcription of MMP14, a metalloprotease involved in angiogenesis and cancer invasion, by binding and suppressing the activity of MMP14 promoter. [Sci Rep] Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers assessed whether transglutaminase 2 plays a causal role in normal and aberrant lung alveolarization. [FEBS J] Abstract Investigators observed that matrix-detached epithelial and carcinoma cells cluster spontaneously via a mechanism that involves the cell adhesion protein PVRL4. They found that this clustering process allows these cells to survive by stimulating a PVRL4/α6β4/Src signaling axis that sustains GPX4 expression and buffers against lipid peroxidation. [J Biol Chem] Abstract | Full Article Invadosome-Mediated Human Extracellular Matrix Degradation by Entamoeba histolytica Scientists showed that the EhMSP-1 silenced parasites cannot efficiently form specialized dot-like polymerized actin structures upon interaction with the human ECM component fibronectin. [Infect Immun] Abstract The authors evaluated in vitro chondrogenic differentiation of dental pulp stem cells from individuals with neurofibromatosis 1 using two-dimensional (2D) and three-dimensional (3D) cultures. [Orphanet J Rare Dis] Full Article miR-21 inhibition reduced ECM protein levels in bleomycin-induced mouse model of pulmonary fibrosis. In human pulmonary fibroblast, miR-21 inhibition reduced transforming growth factor β1-induced ECM protein expression. [J Cell Biochem] Abstract The authors investigated the involvement of the GSK3/βcatenin signaling in the action of ATPγ-S on osteogenic differentiation of primary cell cultures from rat calvaria. [J Cell Biochem] Abstract Scientists report that the fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation by promoting α-1,2 fucosylation. Chemically or genetically increasing the fucose salvage pathway decreased invadopodium numbers and inhibited the proteolytic activity of invadopodia in WM793 melanoma cells. [PLoS One] Full Article The authors investigated the effects of varying the surface properties of two ECMs, collagen I and Matrigel, on placental trophoblast cell morphology, viability, proliferation, and expression of markers involved in differentiation/syncytial fusion. [PLoS One] Full Article Researchers investigated the effect of fibroblast growth factor (FGF)21 on calcification of vascular smooth muscle cell (VSMC) and its mechanism. FGF21 inhibited beta-glycerophosphate induced mineralization in VSMCs as determined by calcium concentration and Alizarin Red S. [Biochem Biophys Res Commun] Abstract Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSExtracellular Matrix-Driven Congenital Muscular Dystrophies The authors summarize the clinical features of two of the most common congenital muscular dystrophies, COL6-related dystrophies and LAMA2-related dystrophies, which are caused by mutations in muscle ECM and basement membrane proteins. [Matrix Biol] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSBoehringer Ingelheim announced a 230 million euro investment into a new Biologicals Development Center at the company’s Research and Development site in Biberach, Germany during the foundation stone laying for the new center. [Boehringer Ingelheim International GmbH] Press Release Health Hub Launches in Collaboration with UCSF UC San Francisco and a newly formed, next-generation nonprofit organization, Health Hub, are announcing their plans to affiliate. Health Hub is designed to help UCSF inventors and qualified entrepreneurs from the local community access the support and professional development they need to grow and build successful companies. [University of California, San Francisco] Press Release | |
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POLICY NEWSScience Candidates: High-Tech Smarts Aren’t Enough for Defeated Obama Aide For many first-time congressional candidates with science and technology backgrounds, fundraising can be a major obstacle. Not to Brian Forde, who was once a senior technology adviser to former-President Barack Obama. [ScienceInsider] Editorial The Karolinska Institute in Stockholm has finally, officially, found disgraced surgeon Paolo Macchiarini guilty of scientific misconduct. However, the verdict is a bitter pill for the four people who raised the alarm about Macchiarini’s fraud. [ScienceInsider] Editorial Top US Court Upholds Trump Travel Ban: Student Visas Already in Decline The travel restrictions now vary by country, and include some exemptions for students. But data from the Department of Justice reveal that the government issued just 289 visas to students from Iran, Libya, Yemen and Somalia in the first three months of this year. [Nature News] Editorial
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EVENTSNEW 2018 National Cancer Research Institute (NCRI) Cancer Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Biomedical Engineering (University of Minnesota) Postdoctoral Researcher – Stem Cell and Regenerative Medicine (NYU Langone Medical Center) Research Associate – Regenerative Medicine (University of Bristol) Director – Davis Center for Regenerative Biology and Medicine (MDI Biological Laboratory) Assistant, Associate or Full Professor – Regenerative Medicine (University of San Diego) Full Professor – Biomedical Sciences (Dublin City University) Postdoctoral Fellow – Bioengineering (Harvard University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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