Extracellular Matrix News Volume 9.26 | Jul 5 2018

TOP STORY

Matrix Metalloprotease-9 (MMP-9)-Producing Monocytes Enable T Cells to Invade the Vessel Wall and Cause Vasculitis

The tissue transcriptome of giant cell arteritis (GCA)-affected temporal arteries contained high amounts of MMP-9 transcripts and immunostaining for pro-MMP-9 localized the enzyme to wall-infiltrating macrophages. MMP-2 and MMP-9 transcripts were also abundant in monocytes and monocyte-derived macrophages from GCA patients. [Circ Res] Abstract | Full Article

(Ranked by impact factor of the journal)

Nanoscale Dysregulation of Collagen Structure-Function Disrupts Mechano-Homeostasis and Mediates Pulmonary Fibrosis

In ex vivo and animal models of lung fibrosis, dual inhibition of lysyl oxidase-like (LOXL) 2 and LOXL3 was sufficient to normalize collagen fibrillogenesis, reduce tissue stiffness, and improve lung function in vivo. [eLife] Full Article | Press Release

Mesenchymal Stem Cells in Combination with Hyaluronic Acid for Articular Cartilage Defects

Researchers investigated the therapeutic effects of bone marrow mesenchymal stem cells combined with hyaluronic acid on articular cartilage repair in canines. [Sci Rep] Full Article

Live Cell Imaging Reveals Focal Adhesions Mechanoresponses in Mammary Epithelial Cells under Sustained Equibiaxial Stress

The authors explored changes in focal adhesion dynamics in HC11 mammary cells in response to a mechanical sustained stress, which resembles the physiological stimuli. They studied the relationship between a global stress and focal adhesion assembly/disassembly, observing an enhanced persistency of focal adhesions under strain as well as an increase in their size. [Sci Rep] Full Article

Exosomes Derived from Calcium Oxalate-Exposed Macrophages Enhance IL-8 Production from Renal Cells, Neutrophil Migration and Crystal Invasion through Extracellular Matrix

Functional investigations revealed that calcium oxalate monohydrate (COM)-treated exosomes enhanced IL-8 production from renal tubular cells, activated neutrophil migration, had increased membrane fragility, had greater binding capacity to COM crystals, and subsequently enhanced crystal invasion through extracellular matrix migration chamber. [J Proteomics] Abstract

Physiological Hypoxia (Physioxia) Impairs the Early Adhesion of Single Lymphoma Cell to Marrow Stromal Cell and Extracellular Matrix. Optical Tweezers Study

Scientists aimed to develop an optical tweezers based assay to precisely evaluate single diffuse large B-cell lymphoma cell adhesion to neighbor cells and extracellular matrix under normoxia and physioxia; and to explore the role of integrins in adhesion of single lymphoma cell. [Int J Mol Sci] Full Article

Cadherin-6B Proteolytic N-Terminal Fragments Promote Chick Cranial Neural Crest Cell Delamination by Regulating Extracellular Matrix Degradation

Investigators report that Cad6B N-terminal fragments promote delamination by enhancing local extracellular proteolytic activity around neural crest cells undergoing epithelial-to-mesenchymal transition en masse. [Dev Biol] Abstract

Staphylococcus aureus Protein A Causes Osteoblasts to Hyper-Mineralize in a 3D Extra-Cellular Matrix Environment

Researchers utilized a collagen glycosaminoglycan scaffold, previously developed for bone tissue engineering, as a representative 3D model of infection. The scaffold resisted degradation and retained its pore structure, which is important for cellular function and survival, when seeded with both cells and bacteria. [PLoS One] Full Article

Fibro/Chondrogenic Differentiation of Dental Stem Cells into Chitosan/Alginate Scaffolds towards Temporomandibular Joint Disc Regeneration

The authors evaluated the potential of chitosan/alginate scaffolds to promote fibro/chondrogenic differentiation of dental pulp stem cells and production of fibrocartilage tissue, serving as a replacement of the natural temporomandibular joint disc. [J Mater Sci Mater Med] Abstract | Graphical Abstract

Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News.

Tumor Matrix Remodeling and Novel Immunotherapies: The Promise of Matrix-Derived Immune Biomarkers

Researchers review tumor matrix dynamics and matrix remodeling in context of anti-tumor immune responses and immunotherapy and propose the exploration of matrix-based biomarkers to identify candidates for immune therapy. [J Immunother Cancer] Full Article

Visit our reviews page to see a complete list of reviews in the extracellular matrix research field.

Servier and Galapagos Announce Start of Global ROCCELLA Phase II Clinical Trial with S201086/GLPG1972 in Osteoarthritis

Servier and the company Galapagos NV announced the start of a global Phase II trial with S201086/GLPG1972 in knee osteoarthritis patients: ROCCELLA. [Servier] Press Release

£215 Million Research Fund to Tackle the Next Generation of Health Challenges

The UK government announced £215 million investment in NHS health research and an additional £3 million for a new research leader programme for nurses and midwives. [Government of UK] Press Release

Hidden Conflicts? Pharma Payments to FDA Advisers after Drug Approvals Spark Ethical Concerns

In examining compensation records from drug companies to physicians who advised FDA on whether to approve 28 psychopharmacologic, arthritis, and cardiac or renal drugs between 2008 and 2014, Science found widespread after-the-fact payments or research support to panel members. The agency’s safeguards against potential conflicts of interest are not designed to prevent such future financial ties. [ScienceInsider] Editorial

Hungarian Academy to Draw Up Alternative Research Budget

The Hungarian Academy of Sciences is set to put forward an “alternative proposal” for the country’s research budget, after the government moved to put the Ministry of Innovation and Technology in charge of financing research institutions, seen as the latest attack on sector autonomy by the authoritarian Orbán administration. [Times Higher Education] Editorial

University of Gothenburg Moves to Fire Professor for Misconduct

The University of Gothenburg has taken steps to remove Suchitra Sumitran-Holgersson from her post as a professor there, after an investigation concluded that she manipulated images in seven out of ten papers. [The Scientist] Editorial

Geneticist Francisco Ayala Quits after Sexual Harassment Accusations

The University of California, Irvine, which found him guilty of inappropriate behavior, will remove Ayala’s name from buildings and scholarships. [The Scientist] Editorial

NEW Cell Symposia: Translation of Stem Cells to the Clinic: Challenges and Opportunities
December 2-4, 2018
Los Angeles, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Assistant – Muscular Dystrophy (Queen Mary University of London)

NEW PhD Fellowship/Scholarship – Nanopatterned Ligands to Study Stem Cell Adhesion and Signaling (Aarhus University)

Postdoctoral Associate – Biomedical Engineering (University of Minnesota)

Postdoctoral Researcher – Stem Cell and Regenerative Medicine (NYU Langone Medical Center)

Postdoctoral Positions – Bone Tissue Regeneration (Stomatological Hospital of Guangzhou Medical University)

Postdoctoral Research Fellow – Skeletal Muscle and Tendon Connective Matrix Biology and Mechanotransduction (Weill Cornell Medical College)

Director – Davis Center for Regenerative Biology and Medicine (MDI Biological Laboratory)

Assistant, Associate or Full Professor – Regenerative Medicine (University of San Diego)

Postdoctoral Fellow – Matrix Biology and Reproduction (University of Texas Southwestern Medical School)

Faculty Position – Developmental Biology and Regenerative Medicine (Seattle Children’s Research Institute)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Extracellular Matrix News? Click here to submit!

Comments or suggestions? Submit your feedback here.