Extracellular Matrix News 9.27 July 12, 2018 | |
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TOP STORYNotch-Inducing Hydrogels Reveal a Perivascular Switch of Mesenchymal Stem Cell Fate Researchers studied mesenchymal stem cells in the perivascular microenvironment of endothelial capillaries by modifying a synthetic 3D biomimetic poly(ethylene glycol)-hydrogel system in vitro. [EMBO Rep] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Human Peroxidasin 1 Promotes Angiogenesis through ERK1/2, Akt and FAK Pathways The authors analyzed the effects of peroxidasin 1 gene silencing and supplementation by recombinant hsPxd01 in TeloHAEC endothelial cells on cell migration, tubulogenesis in matrigel and intracellular signal transduction as assessed by kinase phosphorylation and expression of pro-angiogenic genes as measured by qRT-PCR. [Cardiovasc Res] Abstract Purified mouse cartilage oligomeric matrix protein (COMP) directly induced mouse embryonic stem cell (ESC) differentiation into vascular smooth muscle cells both in vitro and in vivo, while the silencing of endogenous COMP markedly inhibited ESC-VSMC differentiation. [J Mol Cell Cardiol] Abstract miR-34a Exerts as a Key Regulator in the Dedifferentiation of Osteosarcoma via PAI-1-Sox2 Axis By applying bone extracellular matrix-osteosarcoma (OS) models, investigators demonstrated the phenotypic heterogeneity of OS cells, consistent with a strong concordance between plasminogen activator inhibitor-1 (PAI-1) and Sox2 expression levels. [Cell Death Dis] Full Article Three-Dimensional Cell Culture Conditions Affect the Proteome of Cancer-Associated Fibroblasts The authors studied the extra- and intracellular proteomic response of skin fibroblasts isolated from healthy volunteers in comparison to cancer-associated fibroblasts (CAF) in 3D culture conditions. Both control cells and CAF changed their proteomic composition based on the culture conditions. [J Proteome Res] Abstract Researchers investigated the interactions between collagen peptides and other constituents present in liquid collagen-based nutraceuticals on normal primary dermal fibroblast function in a novel, physiologically relevant, cell culture model crowded with macromolecular dextran sulphate. [Sci Rep] Full Article Osteogenic Differentiation of Human Mesenchymal Stem Cells in a 3D Woven Scaffold The differentiation of human mesenchymal stem cells (hMSCs) in vitro was studied on 3D scaffolds and compared with differentiation on 2D substrates having the same material composition. Scientists showed that the 3D woven scaffolds have a major impact on hMSCs proliferation and activation. [Sci Rep] Full Article Inhibition of Integrin αVβ6 Changes Fibril Thickness of Stromal Collagen in Experimental Carcinomas The potential role of αVβ6 integrin-mediated activation of latent TGF-β was studied in cultured KAT-4/HT29 and Capan-2 human ductal pancreatic carcinoma cells as well as in xenograft carcinoma generated by these cells. The monoclonal αVβ6 integrin-specific monoclonal antibody 3G9 was used to inhibit the αVβ6 integrin activity. [Cell Commun Signal] Full Article Nitric Oxide Alters Hyaluronan Deposition by Airway Smooth Muscle Cells Exposure of cultured smooth muscle cells to various nitric oxide (NO) donors results in the accumulation of hyaluronan (HA) in the form of unique, cable-like structures. HA accumulates rapidly after exposure to NO and can be seen as early as one hour after NO treatment. [PLoS One] Full Article Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSAdipokine Dysregulation and Adipose Tissue Inflammation in Human Obesity The mechanisms underlying adipose tissue dysfunction include adipocyte hypertrophy and hyperplasia, increased inflammation, impaired extracellular matrix remodeling and fibrosis together with an altered secretion of adipokines. The authors describe how adipose tissue becomes inflamed in obesity and summarize key players and molecular mechanisms involved in adipose inflammation. [Eur J Clin Invest] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSOsiris Therapeutics, Inc. announced the initiation of its “Multicenter, Prospective, Randomized, Open-Label Study with a Crossover Extension Option to Evaluate the Safety and Efficacy of GrafixPL PRIME™ in the Treatment of Chronic Venous Leg Ulcers.” [Osiris Therapeutics, Inc.] Press Release IsoRay Announces FDA Clearance of GammaTile™ Therapy for the Treatment of Recurrent Brain Neoplasms IsoRay, Inc. announced the receipt of FDA 510(k) regulatory clearance for the brachytherapy technology, known as GammaTile™ Therapy that incorporates proprietary Cesium-131 seeds within customizable collagen-based carriers for the treatment of recurrent brain tumors. [IsoRay, Inc.] Press Release | |
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POLICY NEWSIt’s Time to Burst the Biomedical Bubble in UK Research A new study calls for a rebalancing of research and innovation funding to better meet the UK’s economic, social and health needs. [The Guardian] Editorial Chinese Researchers to Get More Autonomy Over Lab Spending Chinese Premier Li Keqiang says the country will ease restrictive rules governing how research funds are used, and cut red tape for researchers. Revised rules are designed to help researchers focus on their work and compete with their counterparts globally. [Nature News] Editorial UK Universities Fall Short on Reporting Misconduct Investigations The United Kingdom should establish a committee to monitor efforts by the nation’s universities to properly conduct misconduct investigations, a parliamentary inquiry recommends. The guidance follows a new report released on 11 July, revealing that one in four UK universities does not comply with research integrity guidelines released six years ago. [Nature News] Editorial
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EVENTSNEW Federation of American Societies for Experimental Biology (FASEB): Skeletal Muscle Satellite Cells and Regeneration Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Translational GlycOmics Program – Career Development in Glycoscience (BloodCenter of Wisconsin) Postdoctoral Research Assistant – Muscular Dystrophy (Queen Mary University of London) Postdoctoral Associate – Biomedical Engineering (University of Minnesota) Postdoctoral Researcher – Stem Cell and Regenerative Medicine (NYU Langone Medical Center) Director – Davis Center for Regenerative Biology and Medicine (MDI Biological Laboratory) Assistant, Associate or Full Professor – Regenerative Medicine (University of San Diego) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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