Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News| Extracellular Matrix News 9.34 August 30, 2018 | |
 | |
| |
TOP STORYIdentification of a Novel Anoikis Signaling Pathway Using the Fungal Virulence Factor Gliotoxin Researchers identified an anoikis pathway using gliotoxin (GT), a virulence factor of the fungus Aspergillus fumigatus, which causes invasive aspergillosis in humans. GT prevented integrin binding to RGD-containing extracellular matrix components by covalently modifying cysteines in the binding pocket. [Nat Commun] Full Article | |
| |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Investigators report that ribitol, a pentose alcohol with previously unknown function in mammalian cells, partially restored functional O-mannosylation of α-dystroglycan in a dystroglycanopathy model containing a P448L mutation in the fukutin-related protein (FKRP) gene, which is clinically associated with severe congenital muscular dystrophy. [Nat Commun] Full Article Midgut Laterality Is Driven by Hyaluronan on the Right Whereas hyaluronan (HA) is normally synthesized bilaterally as a simple polysaccharide, the authors showed that covalent modification of HA by the enzyme Tsg6 on the right triggered distinct cell behavior necessary to drive the conserved midgut rotation and to pattern gut vasculature. [Dev Cell] Full Article | Graphical Abstract Visualizing Collagen Proteolysis by Peptide Hybridization: From 3D Cell Culture to In Vivo Imaging Researchers showed that fluorescently labeled collagen hybridizing peptide robustly visualized the pericellular matrix turnover caused by proteolytic migration of cancer cells within 3D collagen culture, without the use of synthetic fluorogenic matrices or genetically modified cells. [Biomaterials] Abstract Scientists demonstrated that ALDH+ human oral squamous cell carcinoma (OSCC) cells are characterized by upregulated expression of the pluripotency transcription factors OCT4, Nanog and Sox2, as well as exhibit enhanced cancer stemness, as demonstrated by enhanced tumorsphere formation. [Sci Rep] Full Article A novel 3D tumor-tissue invasion model which supports rapid, reproducible setup and user-definition of tumor and surrounding tissue compartments was developed. High-cell density tumor compartments were created using a custom-designed fabrication system and standardized oligomeric type I collagen to define and modulate ECM physical properties. [Sci Rep] Full Article The authors investigated multiscale changes of stiffness induced by chronic intermittent hypoxia in the ECM of left ventricular myocardium in a murine model of obstructive sleep apnea. [Front Physiol] Full Article Increased Extracellular Matrix Density Disrupts E-Cadherin/β-Catenin Complex in Gastric Cancer Cells Using a density-varying ECM, scientists studied the effect of ECM density on both intercellular- and ECM-interactions according to alterations of ECM-mediated signaling. [Biomater Sci] Abstract Investigators determined the effects of piperlongumine on cardiac fibroblasts proliferation, and extracellular matrix (ECM) production under angiotensin II conditions, and further investigated the underlying molecular mechanism. [J Cell Biochem] Abstract Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
| |
| |
REVIEWSBiomimetic Delivery of Signals for Bone Tissue Engineering The authors review biomimetic strategies in signaling delivery for bone tissue engineering, with a focus on delivery systems rather than specific molecules. Both fundamental considerations and specific design strategies are discussed with examples of recent research progress, demonstrating the significance and potential of biomimetic delivery systems for bone tissue engineering. [Bone Res] Full Article Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
| |
INDUSTRY NEWSOrgenesis Inc., along with BGN Technologies and the National Institute for Biotechnology in the Negev, announced a collaboration to develop and commercialize a novel alginate scaffold technology for cell transplantation with an initial focus on autoimmune diseases. [Orgenesis Inc.] Press Release UTA Bioengineer to Develop Hydrogel to Repair Heart Tissue after Heart Attacks A University of Texas at Arlington (UTA) bioengineering professor has won a new $460,000 grant from the National Institutes of Health to develop a biodegradable and bioactive hydrogel to repair heart tissue after heart attacks. [The University of Texas at Arlington] Press Release | |
| |
POLICY NEWSClinical Trials Have Far Too Little Racial and Ethnic Diversity The symptoms of conditions such as heart disease, cancer and diabetes, as well as the contributing factors, vary across lines of ethnicity, as they do between the sexes. If diverse groups aren’t part of these studies, we can’t be sure whether the treatment will work in all populations or what side effects might emerge in one group or another. [Scientific American] Editorial Top UK Genomics Institute Investigates Bullying Allegations An investigation into allegations of bullying is under way at one of the world’s top genomics centers — the Wellcome Sanger Institute in Hinxton, UK. According to The Guardian, which first reported on the investigation at Sanger, the complaints come from current and former staff members and include allegations against the institute’s director, geneticist Michael Stratton, who has been at the helm since 2010. [Nature News] Editorial Yale Prof Gets Endowed Chair Four Years After Harassment Finding Michael Simons, a Yale School of Medicine professor who was removed from a leadership post in 2014 after the university found him guilty of sexual harassment, was given an endowed professorship in the school’s cardiology department. In response, faculty members “went into an uproar,” and the school removed an online press release about Simons’s honor, Yale Daily News reported. [The Scientist] Editorial New Research: Financial Disclosure Lacking in Publication of Clinical Trials A substantial proportion of pharmaceutical industry payments to authors of oncology clinical trials published in major scientific journals are not disclosed, new research shows. The publications focused on clinical trials that tested new cancer drugs. The new findings were published as a research letter in the journal JAMA Oncology. [OHSU] Editorial
| |
EVENTSNEW EMBO Workshop “Molecular Mechanisms of Developmental and Regenerative Biology” NEW TERMIS-EU 2019 Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Position – Extracellular Matrix Research (University of Pennsylvania) NEW Postdoctoral Position – Cutaneous Wound Repair (University of Pennsylvania) Faculty Positions – Biomedical Research (Memorial Sloan Kettering Cancer Center) Tenure Track Fellowships – Aging and Chronic Disease (University of Liverpool) Postdoctoral Associate – Matrix Biology (Massachusetts Institute of Technology) Postdoctoral Scholar – Cellular Mechanobiology (Washington University in St. Louis) Postdoctoral Position – ECM and Cancer (The University of Illinois at Chicago) Translational GlycOmics Program – Career Development in Glycoscience (BloodCenter of Wisconsin) Assistant, Associate or Full Professor – Regenerative Medicine (University of San Diego) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Extracellular Matrix News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
