Extracellular Matrix News 9.44 November 8, 2018 | |
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TOP STORYGene Signature Discovery May Predict Response to Immune Therapy Scientists have discovered a gene signature biomarker that may predict which patients will respond – or not – to immune therapy. They say the gene signature relates to the body’s molecular network called the ECM that underpins and physically supports cells. [Press release from University Health Network discussing online prepublication in Nature Communications] Press Release | Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Myh10 Deficiency Leads to Defective Extracellular Matrix Remodeling and Pulmonary Disease From omics analyses and follow up studies, the authors found decreased thrombospondin expression accompanied with increased matrix metalloproteinase activity in both mutant lungs and cultured mutant fibroblasts, as well as disrupted ECM remodeling. [Nat Commun] Full Article A 3D-bioprinted patch containing cardiac extracellular matrix hydrogel (cECM) for delivery of pediatric human cardiac progenitor cells (hCPCs) was developed. Cardiac patches were printed with bioinks composed of cECM, hCPCs, and gelatin methacrylate (GelMA). GelMA-cECM bioinks printed uniformly with a homogeneous distribution of cECM and hCPCs. [Adv Healthc Mater] Abstract Researchers investigated whether IQ-domain GTPase-activating protein 1 (IQGAP1) forms a signalosome with endothelin-1/β-arrestin1 network, as signal-integrating module for adhesion components, cytoskeletal remodeling and ECM degradation. [Matrix Biol] Full Article Development of a 3D Collagen Model for the In Vitro Evaluation of Magnetic-Assisted Osteogenesis Investigators demonstrated that static magnetic fields, iron oxide nanoparticles and the collagen matrix could stimulate the proliferation, alkaline phosphatase production and mineralization of MG-63 cells, by influencing matrix/cell interactions and encouraging the expression of Runx2, ON, BMP-2 and BMP-4. [Sci Rep] Full Article Scientists demonstrated efficient tissue engineering approaches applied to normal breast and breast cancer ECM starting from decellularized human biopsies to generate a three-dimensional bioactive model with sodium lauryl ether sulfate solution. [J Cell Physiol] Abstract Researchers found that spontaneous Ca2+ signal of in situ porcine chondrocytes was [Ca2+]o dependent, and mediated by [Ca2+]i store release. T-type voltage-dependent calcium channel mediated [Ca2+]o influx was associated with decreased cell viability and expression levels of ECM deposition genes. [J Cell Physiol] Abstract Scientists investigated the ex vivo mechanisms of action of the Agili-C™ implant in the repair of full-thickness cartilage defects. [Knee Surg Sports Traumatol Arthrosc] Abstract | Press Release The authors determined the potential effects of amniotic suspension allografts on tenocyte cell density, migration, and responses to inflammatory stimuli. Tenocyte cell density was measured using AlamarBlue over multiple time points, while migration was determined using a Boyden chamber assay. [J Orthop Res] Abstract | Full Article Investigators compared cumulus-oocyte complexes before expansion and at late-stage expansion. Using histochemistry the levels of hyaluronan, heavy chains, pentraxin 3, tumor necrosis factor-stimulated gene 6 and phosphorylated-SMAD1/5/8 and -SMAD2 were assessed. [Reprod Fertil Dev] Abstract Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSDissecting Cellular Mechanics: Implications for Aging, Cancer, and Immunity The authors review recent work on the characterization of cell mechanics in disease and discuss the implications of altered viscoelasticity in regulation of immune responses. [Semin Cell Dev Biol] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSOxurion and Beta Therapeutics to Develop New Heparanase Inhibitors for Treatment of Dry AMD Oxurion NV announced that it entered into a strategic research collaboration with Beta Therapeutics Pty Ltd to develop new heparanase inhibitors for the treatment of retinal disorders with large unmet medical needs such as dry age-related macular degeneration. [Oxurion NV] Press Release Ophthotech Corporation announced that it has acquired Inception 4, Inc. expanding Ophthotech’s therapeutic pipeline in age-related retinal indications. Through this acquisition, Ophthotech gains worldwide development and commercialization rights to Inception 4’s small molecule inhibitors of high temperature requirement A serine peptidase 1 protein. [Ophthotech Corporation] Press Release | |
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POLICY NEWSScientists Struggle with Confusing Journal Guidelines Globally, more than two-thirds of researchers find it difficult to prepare manuscripts and to respond to peer-review comments, finds a survey of nearly 7,000 researchers from over 100 countries. [Nature News] Editorial Open-Access Plan Draws Online Protest Hundreds of scientists are pushing back against Plan S, a plan to crack down on scholarly journals’ paywalls, launched 2 months ago by 11 national research funders in Europe. In an open letter published on 5 November, about 800 signatories say they support open access—making papers available free to all readers online—but condemn Plan S as “too risky for science.” [ScienceInsider] Editorial Europe’s Researchers Benefit From Reduced Bureaucracy The European Union has made good on its promise to reduce the amount of red tape that scientists must wade through when applying for grants from its flagship funding program, according to a report released by the European Court of Auditors. [Nature News] Editorial
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EVENTSNEW EMBO-EMBL Symposia: Synthethic Morphogenesis: From Gene Circuits to Tissue Architecture Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Pathogenesis of Sepsis and Lung Inflammation (Boston University) NEW Postdoctoral Fellowship Program – Aging (Niigata University) Associate Professor/ Professor – Regenerative Medicine (University of Toronto) Research Fellow – Immunology (King’s College London) Faculty Position – Biochemistry & Molecular Biology (Mayo Clinic) Postdoctoral Fellow – Bone Regeneration (University of Michigan) Tenure Track Assistant Professor – Biochemistry and Life Sciences (University of Delaware) Postdoctoral Position – Cutaneous Wound Repair (University of Pennsylvania) Postdoctoral Scholar – Cellular Mechanobiology (Washington University in St. Louis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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