Extracellular Matrix News 9.47 November 29, 2018 | |
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TOP STORYMechanosignaling via Integrins Directs Fate Decisions of Pancreatic Progenitors Mechanistic studies identified the interaction of the ECM with integrin α5 as the extracellular cue that cell-autonomously, via the F-actin-YAP1-Notch mechanosignaling axis, controlled the fate of bipotent pancreatic progenitors. Whereas ECM-integrin α5 signaling promoted differentiation towards the duct lineage, endocrinogenesis was stimulated when this signaling cascade was disrupted. [Nature] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Mutant p53s Generate Pro-Invasive Niches by Influencing Exosome Podocalyxin Levels Exosomes from mutant p53-expressing tumor cells influenced integrin trafficking in normal fibroblasts to promote deposition of a highly pro-invasive ECM, and quantitative second harmonic generation microscopy indicated that this ECM displayed a characteristic orthogonal morphology. [Nat Commun] Full Article Through its receptor neogenin-1, netrin-1 induced a robust intracellular calcium flux necessary for the transcriptional regulation and persistent catalytic activation of matrix metalloproteinase-3 (MMP3) by vascular smooth muscle cells. Deficiency in MMP3 reduced ECM damage and the susceptibility of mice to develop abdominal aortic aneurysms. [Nat Commun] Full Article Magnetic hyperthermia is a promising therapy for the localized treatment of cancer based on the exposure of magnetic nanoparticles to an external alternating magnetic field. In order to evaluate some of the mechanisms involved in the cellular damage caused by this treatment, two different 3D cell culture models were prepared using collagen, which is the most abundant protein of the ECM. [ACS Appl Mater Interfaces] Abstract Mutation of p53 and activation of KRAS did not increase the viability of murine oviductal epithelial (MOE) cells on 3D collagen. In contrast, loss of PTEN allowed MOE cells to retain normal viability on 3D collagen. Loss of PTEN activated AKT and RAC1/JNK signaling that each contributed to the increased viability, invasion, and attachment in the collagen rich ovarian microenvironment. [Carcinogenesis] Abstract The migration and invasion of extravillous trophoblast (EVT) cells were maximized at the highest dosage of 5 μg/ml of total flavonoids from S. cuscutae (TFSC). The expression of matrix metalloproteinase 9 (MMP9) in EVT cells was significantly increased after TFSC treatment. [Sci Rep] Full Article VANGL2 Protein Stability Is Regulated by Integrin αv and the Extracellular Matrix While integrin αv knockdown reduced vang-like 2 (VANGL2) expression at membrane compartments, it did not affect VANGL2 transcription. Knockdown of integrin β5, but not β1 or β3, also decreased VANGL2 protein levels. Researchers further showed integrin activation and stimulation of cell-matrix adhesion using MnCl2 failed to influence VANGL2. [Exp Cell Res] Abstract Investigators showed that the four marine collagen hydrolysates (MCHs) had no degree of toxicity on the cell lines analyzed; conversely, they were able to stimulate cell growth. They showed a significant antioxidant activity both in cell-free assays as well as in H2O2 or quartz-stimulated macrophages, going from 23% to 60% of reactive oxygen species (ROS) scavenging activity for the four MCHs. [Mar Drugs] Full Article C11 inhibited breast cancer MDA-MB-231 cell migration and invasion via suppression of FGFR1 phosphorylation and its downstream signaling pathway. Suppression of matrix metalloproteinases 2/9 was associated with the anti-motility activity of C11. [Acta Pharmacol Sin] Abstract Scientists aimed to develop a serum-free myogenic differentiation medium for the co-culture of primary myoblasts and mesenchymal stromal cells derived from the bone marrow and adipose tissue on electrospun poly-ε-caprolacton (PCL)-collagen I-nanofibers. [BMC Biotechnol] Full Article Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSThe authors cover the cutting edge in vascular smooth muscle cell modeling of elastin-associated vasculopathy, and aid in the development of human disease modeling and drug screening approaches to identify potential treatments. [Cell Mol Life Sci] Abstract Endothelial Cell Mechanotransduction in the Dynamic Vascular Environment Investigators describe the molecular mechanisms by which endothelial cells perceive and interpret mechanical signals. The translational applications of mechanosensing are then discussed in the context of endothelial-to-mesenchymal transition and engineering of vascular grafts. [Adv Biosyst] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSTen New Collaborative Research Centres The Deutsche Forschungsgemeinschaft is establishing ten new Collaborative Research Centres (CRCs) to further support top-level research in Germany. The new CRCs will receive a total of approximately €120.3 million in funding for an initial four-year period starting on 1 January 2019. [DFG] Press Release ERC Awards €573 Million to Mid-Career Researchers from 40 Countries The European Research Council (ERC) announced the recipients of its Consolidator Grant competition: 291 top scientists across Europe. Funding for these researchers, part of the Horizon 2020 research and innovation program, is worth in total €573 million and will give them a chance to build up their teams and have far-reaching impact. [The European Research Council] Press Release Generex Biotechnology Corporation announced that the company has signed a Binding Letter of Intent to acquire 51% of Regentys Corporation. The company’s first product, Regentys Extra-Cellular Matrix Hydrogel, is a first-in-class, non-pharmacologic, non-surgical treatment option for patients suffering from ulcerative colitis. [Generex Biotechnology Corp.] Press Release | |
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POLICY NEWSDoes Science Have a Bullying Problem? A spate of bullying allegations have rocked several high-profile science institutions. Here’s how researchers, universities, funders and others are dealing with the issue. [Nature News] Editorial Romania Cuts Research Budget for Second Time This Year The Romanian government has sliced off another €49 million from its research budget, as the ministry for research and innovation failed to put out funding calls to spend all of the €350 million it had allocated for 2018. [Science|Business] Editorial Some Research May Be Encouraging Ineffective Prescriptions, Says New Study A new paper published by McGill University researchers in JAMA Internal Medicine suggests that some clinical trials may promote the use of ineffective and costly treatments. That’s the opposite of what clinical trials are aimed at, namely preventing ineffective and costly treatments from being taken up by physicians and patients. [McGill University] Editorial Biomedical Research Is Becoming More Open about Its Funding and Data Biomedical research is shifting to become more open and transparent by providing increasing amounts of information about funding, conflicts of interest and data sharing in their publications, according to a survey of recent papers. [Nature News] Editorial
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EVENTSNEW Gordon Research Seminar: New Views of Organogenesis and Tumorigenesis: From Single Molecules to Therapeutics Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Position – Regenerative Medicine, Stem Cells & Bioengineering (Igenomix Foundation) Tenured Track Faculty Position – Biomedical Engineering (Johns Hopkins University) Postdoctoral Research Fellow – Pathogenesis of Sepsis and Lung Inflammation (Boston University) Postdoctoral Fellowship Program – Aging (Niigata University) Associate Professor/ Professor – Regenerative Medicine (University of Toronto) Research Fellow – Immunology (King’s College London) Faculty Position – Biochemistry & Molecular Biology (Mayo Clinic) Postdoctoral Scholar – Cellular Mechanobiology (Washington University in St. Louis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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