Extracellular Matrix News 9.50 December 20, 2018 | |
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TOP STORYResearchers demonstrated by an independent control of fibril diameter and intrafibrillar crosslinking of three-dimensional (3D) collagen matrices that fibril bending stiffness instructs cell behavior of invasive and non-invasive breast cancer cells. [Biomaterials] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scanningless and Continuous 3D Bioprinting of Human Tissues with Decellularized Extracellular Matrix Investigators describe a method to produce photocrosslinkable tissue-specific decellularized ECM bioinks for fabricating patient-specific tissues with high control over complex microarchitecture and mechanical properties using a digital light processing-based scanningless and continuous 3D bioprinter. [Biomaterials] Abstract | Graphical Abstract Scientists designed and synthesized a new bioactive and biocompatible hydrogel, Nap-GFFYK-Thiol, using disulfide bonds as cleavable linkers to control molecular self-assembly and they hypothesized this hydrogel could enhance the retention and engraftment of human placenta-derived mesenchymal stem cells in a mouse ischemic hindlimb model. [Acta Biomater] Abstract | Graphical Abstract Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland A murine model with fibroblast-specific Pten deletion was used to examine how PTEN regulates matrix remodeling. Using second harmonic generation microscopy, Pten deletion was found to promote collagen alignment parallel to the mammary duct in the normal gland and further remodeling perpendicular to the tumor edge in tumor-bearing mice. [Neoplasia] Full Article The authors investigated the effect of the integrin α5 priming synthetic cyclic peptide on proliferation, migration, and the odontogenic differentiation of dental pulp stem cells. [J Cell Physiol] Abstract Investigators reported that NEAT1 was significantly increased in streptozotocin‐induced diabetic nephropathy (DN) rat models and high‐glucose‐induced mice mesangial cells. They observed that knockdown of NEAT1 greatly inhibited renal injury of DN rats. [J Cell Physiol] Abstract Bone morphogenetic protein‐7 as a vital factor for kidney development and regeneration was incorporated in polycaprolactone nanofibers and after morphological, mechanical, and biocompatible characterization, proliferation, and survival of human embryonic kidney cells were investigated using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, flow cytometry, and gene expression while cultured on scaffolds. [J Cell Biochem] Abstract Researchers investigated ECM to specify adhesive substrates to human dura mater cell (hDMC), the alteration on adhesion‐related molecules in hDMC, and secreted matrix metalloproteinases linked with ECM remodeling after exposure to inflammation. [J Orthop Res] Abstract Scientists determined the effect of adipose-derived stem cells (ADSCs) on production of growth factors and expression levels of intergrins in primary culture of adult human melanocytes with or without ADSCs and in nude mice grafted with such melanocytes. [Biomol Ther (Seoul)] Abstract Subscribe to one of our other 19 science newsletters such as Endothelial Cell News & Dermal Cell News. | |
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REVIEWSRho-ROCK Signaling Regulates Tumor-Microenvironment Interactions The authors briefly discuss the current state of knowledge on the role of Rho-ROCK signaling in regulating the tumor microenvironment and the implications of this knowledge for therapy, potentially via the development of selective inhibitors of the components of this pathway to permit the tuning of signaling flux, including one example with demonstrated utility in pre-clinical models. [Biochem Soc Trans] Abstract Visit our reviews page to see a complete list of reviews in the extracellular matrix research field. | |
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INDUSTRY NEWSGilead Sciences, Inc. and Scholar Rock Holding Corporation announced that the companies have entered into a strategic collaboration to discover and develop highly specific inhibitors of transforming growth factor beta activation for the treatment of fibrotic diseases. [Gilead Sciences, Inc.] Press Release Generex Biotechnology Corporation announced that Regentys Corporation was granted European Patent No. 2983616 entitled “Method And Composition For Treating Inflammatory Bowel Disease Without Colectomy.” [Generex Biotechnology Corporation] Press Release DiscGenics, Inc. announced the Japanese Pharmaceuticals and Medical Devices Agency has approved a Clinical Trial Notification application for IDCT, an allogeneic injectable disc cell therapy for the treatment of degenerative disc disease. [DiscGenics, Inc.] Press Release | |
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POLICY NEWSUniversity of California Squares Off against Major Publisher, With Big Stakes for Access to Research There’s a high-stakes fight in California that could shape the way that academic research gets read and published far beyond the West Coast. The battle is pitting the University of California system against Elsevier, the Netherlands-based publisher of academic journals. At issue is how open-access research gets paid for. [STAT News] Editorial Canadian Government Ending Networks of Centres of Excellence Program Canada’s federal government is ending a 30-year-old research funding program, the Networks of Centres of Excellence, leaving researchers uncertain about where future funding will come from, The Globe and Mail reports. The program will be phased out over the course of the next three years, according to a spokesperson for Science Minister Kirsty Duncan. [The Scientist] Editorial Plan S: The Ambitious Initiative to End the Reign of Paywalls Efforts to eradicate paywalls have been gaining stream in Europe. Over the last few years, university consortia in several countries have been pushing for open-access agreements in negotiations that have occasionally led to heated stalemates. [The Scientist] Editorial Australia Cuts Research Funding for Universities Australian scientists have expressed disappointment over an AU$328.5 million cut to research funding that had been expected over the next four years. In a budget update, the government announced that it will freeze funding increases for the program that supports research, facilities, and training, including of PhDs, at universities. [Nature News] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) 2019 Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Assistant Professor – Sarcoma & Skeletal-Related Malignancies (UC Davis School of Medicine) NEW Postdoctoral Fellow – Extracellular Matrix (UCSF School of Medicine) Scientist – Matrix Biology (STEMCELL Technologies Inc.) Lecturers/ Senior Lecturers – Department of Bioengineering (Imperial College London) Postdoctoral Position – Regenerative Medicine, Stem Cells & Bioengineering (Igenomix Foundation) Tenured Track Faculty Position – Biomedical Engineering (Johns Hopkins University) Postdoctoral Research Fellow – Pathogenesis of Sepsis and Lung Inflammation (Boston University) Postdoctoral Fellowship Program – Aging (Niigata University) Associate Professor/ Professor – Regenerative Medicine (University of Toronto) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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