CURRENT PUBLICATIONS LABORATORY RESEARCH Epigenetic Chromatin States Uniquely Define the Developmental Plasticity of Murine Hematopoietic Stem Cells Heritable epigenetic signatures are proposed to serve as an important regulatory mechanism in lineage fate determination. To investigate this, researchers profiled chromatin modifications in murine hematopoietic stem cells, lineage-restricted progenitors, and CD4+ T cells using modified genome-scale mini-chromatin immunoprecipitation technology. [Blood] Haploinsufficiency of Apc Leads to Ineffective Hematopoiesis This study shows that the conditional inactivation of a single allele of Apc in mice leads to the development of severe anemia with macrocytosis and monocytosis. [Blood] The Downregulation of Onzin Expression by PKC(epsilon)-ERK2 Signaling and its Potential Role in Acute Myeloid Leukemia Cell Differentiation Researchers provide the first demonstration that onzin expression is significantly downregulated during differentiation induction of acute myeloid leukemic cell lines and primary cells by all-trans retinoic acid and especially by phorbol 12-myristate 13-acetate. [Leukemia] Development and Function of Myeloid-Derived Suppressor Cells Generated from Mouse Embryonic and Hematopoietic Stem Cells Functional myeloid-derived suppressor cells can be efficiently generated from mouse embryonic stem cells and bone marrow hematopoietic stem cells. [Stem Cells] Wnt Signaling in Hematopoiesis: Crucial Factors for Self-Renewal, Proliferation, and Cell Fate Decisions While in the thymus Wnt signaling provides cytokine-like, proliferative stimuli to developing thymocytes, canonical Wnt signaling in hematopoietic stem cells regulates cells fate decisions, in particular self-renewal versus differentiation. [J Cell Biochem] Rac1 and Rac2 GTPases are Necessary for Early Erythropoietic Expansion in the Bone Marrow but Not in the Spleen Rac1 and Rac2 GTPases are essential for normal bone marrow erythropoiesis but they are dispensable for erythropoiesis in the spleen, implying different signaling pathways for homeostatic and stress erythropoiesis. [Haematologica] CLINICAL RESEARCH Testing the Natural Killer T Cell Hypothesis in Lenalidomide-Treated Myelodysplastic Syndrome Patients Study data challenge the concept that natural killer T (NKT) cell defects contribute to the development of myelodysplastic syndrome, and shows that a clinical response to lenalidomide is not dependent on modulation of NKT cell frequency or function. [Leukemia] Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy This study shows the potent biological activity of recombinant human IL-7 in humans over a well-tolerated dose range and allows further exploration of its possible therapeutic applications. [Clin Cancer Res]
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