CURRENT PUBLICATIONS LABORATORY RESEARCH The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal Lmo2 promotes the self-renewal of preleukemic thymocytes, providing a mechanism by which committed T cells can then accumulate additional genetic mutations required for leukemic transformation. [Science] Transferrin Therapy Ameliorates Disease in Beta-Thalassemic Mice Results indicate that transferrin is a limiting factor contributing to anemia in these mice and suggest that transferrin therapy might be beneficial in human beta-thalassemia. [Nat Med] Knockdown of Fanconi Anemia Genes in Human Embryonic Stem Cells Reveals Early Developmental Defects in the Hematopoietic Lineage Researchers have created a human-specific in vitro system to study early hematopoietic development in Fanconi anemia using a lentiviral RNAi strategy in human embryonic stem cells. [Blood] Investigation of Murine Spleen as a Niche for Hematopoiesis Evidence for the maintenance of donor-type myeloid cells after 2 to 4 weeks reflected development from hematopoietic progenitors endogenous to spleen. Overall, this study adds further evidence that spleen can support endogenous myelopoiesis. [Transplantation] FOG-1-Mediated Recruitment of NuRD is Required for Cell Lineage Re-Enforcement During Hematopoiesis To test the importance of transcriptional co-factor Friend of GATA1 (FOG-1)/nucleosome remodelling and histone deacetylase (NuRD) interaction for hematopoiesis in vivo, researchers generated mice with a mutation that specifically disrupts FOG-1/NuRD interaction. [EMBO J] Cyclin C Regulates Human Hematopoietic Stem/Progenitor Cell Quiescence Researchers have identified an important role of cyclin C (CCNC) in regulating human hematopoietic stem/progenitor cell quiescence, as knocking down CCNC expression in human cord blood CD34+ cells resulted in a significant increase in quiescent cells that maintain CD34 expression. [Stem Cells] Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells This study compared the gene expression profiles of steady-state bone marrow hematopoietic stem cells (HSCs) to non-self-renewing multipotent progenitors; to HSC treated with mobilizing drugs that expand the HSC pool and induce egress from the marrow; and to leukemic HSC in a mouse model of chronic myelogenous leukemia. [PLoS ONE] Extrinsic Signals Determine Myeloid-Erythroid Lineage Switch in MN1 Leukemia To test whether the microenvironment impacts on leukemic phenotype, researchers exploited the MN1 model of acute myeloid leukemia under defined genetically-modified microenvironmental conditions. [Exp Hematol]
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