Hematopoiesis News Volume 1.05 | Feb 16 2010

Blood Stem Cells Emerge from Aortic Endothelium by a Novel Type of Cell Transition
Using non-invasive, high-resolution imaging of live zebrafish embryos, researchers show that hematopoietic stem cells emerge directly from the aortic floor, through a stereotyped process that does not involve cell division but a strong bending then egress of single endothelial cells from the aortic ventral wall into the sub-aortic space, and their concomitant transformation into hematopoietic cells. [ Nature]

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Biologists Image Birth of Blood-Forming Stem Cells in Embryo
Biologists at UC San Diego have identified the specific region in vertebrates where adult blood stem cells arise during embryonic development. [Press Release from ScienceDaily discussing online prepublication in Nature]
 

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CURRENT PUBLICATIONS

LABORATORY RESEARCH

In Vivo Imaging of Hematopoietic Cells Emerging from the Mouse Aortic Endothelium
The dynamic de novo emergence of phenotypically defined hematopoietic stem cells (Sca1+, c-kit+, CD41+) directly from ventral aortic hemogenic endothelial cells was illustrated. [Nature]

Impact of Interactions of Cellular Components of the Bone Marrow Microenvironment on Hematopoietic Stem and Progenitor Cell Function
Researchers examined the impact of hematopoietic niche elements on hematopoietic stem and progenitor function by analyzing the combined effect of osteoblasts and stromal cells on Lineage- Sca1+ CD117+ cells. [Blood]

The Midregion, Nuclear Localization Sequence, and C Terminus of PTHrP Regulate Skeletal Development, Hematopoiesis, and Survival in Mice
The results establish that the midregion, nuclear localization sequence, and C terminus of parathyroid hormone-related protein (PTHrP) are crucial for the commitment of osteogenic and hematopoietic precursors to their lineages, and for survival, and many of the effects of PTHrP on development are not mediated by its N terminus. [FASEB J]

Dasatinib Inhibits the Growth of Molecularly Heterogeneous Myeloid Leukemias
Because Src kinases contribute to multiple blood cell functions by triggering a variety of signaling pathways, researchers hypothesized that their molecular targeting might lead to growth inhibition in acute myeloid leukemia. [Clin Cancer Res]

Hematopoietic Stem Cells in Coculture with Mesenchymal Stromal Cells – Modelling the Niche Compartments In Vitro
Here researchers investigated in detail the spatial relationship between hematopoietic stem cells and mesenchymal stromal cells during ex-vivo expansion. [Haematologica]

Role of Chk1 in the Differentiation Program of Hematopoietic Stem Cells
Hematopoietic stem cells isolated from umbilical cord blood were treated with ionizing radiation (IR) and sensitivity and IR induced checkpoints activation were investigated. [Cell Mol Life Sci]

Comparative Transfection of DNA into Primary and Transformed Mammalian Cells from Different Lineages
Studies were undertaken to evaluate and compare the transfection efficacy of several chemical reagents to that of the electroporation/nucleofection system using both adherent cells (primary and transformed airway epithelial cells and primary fibroblasts as well embryonic stem cells) and cells in suspension (primary hematopoietic stem/progenitor cells and lymphoblasts). [ BMC Biotechnol]

Genomic Approaches Uncover Increasing Complexities in the Regulatory Landscape at the Human SCL (TAL1) Locus
To elaborate further the DNA elements which control the regulation of the SCL (TAL1) transcription factor, researchers used genomic tiling microarrays covering 256 kb of the human SCL locus to perform a concerted analysis of chromatin structure and binding of regulatory proteins in human hematopoietic cell lines. [PLoS One]

CLINICAL RESEARCH

Sustained Molecular Response With Interferon Alfa Maintenance After Induction Therapy With Imatinib Plus Interferon Alfa in Patients With Chronic Myeloid Leukemia
Treatment with interferon alfa-2a (IFN) enables discontinuation of imatinib in most patients after prior imatinib/IFN combination therapy and may result in improved molecular response. [J Clin Oncol]

Clinical Characteristics and Outcomes of Adults with Philadelphia Chromosome Positive and/or Bcr-Abl Positive Acute Lymphoblastic Leukemia: a Single Center Study from China
The results of the study indicated that introducing imatinib into treatment of patients with Ph-positive acute lymphoblastic leukemia could improve complete remission rate and survival, especially as early as possible, and allogenic stem cell transplantation was still the first choice for these patients if they had suitable donors. [Leuk Lymphoma]

Outcome of Allogeneic Bone Marrow Transplantation from Unrelated Donors for Adult Philadelphia Chromosome-Negative Acute Lymphocytic Leukemia in First Complete-Remission
The study suggested that unrelated allogeneic stem cell transplantation (allo-SCT) could improve leukemia-free survival of patients with a potential graft-versus-leukemia effect. [Int J Hematol]

New 10-Year United Kingdom Blood Stem Cell Strategy to be Created
Gillian Merron, Public Health Minister, has asked the National Health Service Blood and Transplant to lead a team of experts in creating a new 10-year strategy for the provision of blood stem cells, including those from cord blood to fight leukemias and other blood disorders. [National Health Service Blood and Transplant Press Release]

National Institutes of Health Grants to Children’s Hospital Will Advance Novel Stem Cell Treatments for Blood Disorders
Two large federal grants recently awarded to The Children’s Hospital of Philadelphia will advance the frontiers of research into cellular therapies. Both programs aim to engineer human cells into new generations of cells and tissues for patients suffering from blood diseases, cancer and, likely, a greater range of other disorders. [PR Newswire]

Ablynx Selects GPCR Targeting Development Candidate, Announces New Data on Alternative Routes of Delivery for Nanoantibodies and Provides an R&D Update
Ablynx announced that it has selected a new GPCR targeting development candidate, ALX-0651, an anti-CXCR4 Nanobody which is being developed for hematopoietic stem cell mobilization. [Ablynx Press Release]

Biologics, Inc. Selected to Provide Pharmacy Management Services in National Marrow Donor Program Clinical Trial
Biologics, Inc. announced that its Oncology Clinical Trial Services division has been selected by the National Marrow Donor Program®, a nonprofit organization that facilitates unrelated hematopoietic cell transplants.
[Biologics Inc. Press Release]

Stem Cell Therapy Board Elects HistoStem CEO Hoon Han Chairman
Dr. Hoon Han, president and chief executive of HistoStem Co. Ltd., was elected chairman of the board of Stem Cell Therapy International Inc. [Tampa Bay Business Journal]

Data Monitoring Committee Recommends Continuation of Phase III Study of StemEx®, a Cord Blood Stem Cell Product, for Leukemia and Lymphoma
The Gamida Cell-Teva Joint Venture (JV) announced that the Data Monitoring Committee has independently reviewed preliminary data from the pivotal registration, Phase III clinical trial of StemEx (called ExCell) and has recommended that the JV continue to enroll patients in this study. [Gamida Cell Press Release]

Athersys Receives U.S. Patent Covering Adult Stem Cell Composition & Production
Athersys, Inc. announced that it has been granted U.S. patent 7,659,118 that covers non-embryonic multipotent stem cells, their isolation and expansion, and related pharmaceutical compositions. [Athersys Inc. Press Release]

Delays in Grant Application Submission due to Widespread Winter Storm (NOT-OD-10-061) [National Institutes of Health, United States]

Recovery Act Limited Competition: Program to Enhance National Institutes of Health-Supported Global Health Research Involving Human Subjects (S07) (RFA-OD-10-006) [National Institutes of Health, United States]

Institutional Clinical and Translational Science Award (U54) (RFA-RM-10-001) [National Institutes of Health, United States] 

IACUC 101 Workshop and PRIM&R 2010 IACUC Conference: March 21-23, 2010 in Baltimore, MD (NOT-OD-10-059) [National Institutes of Health, United States]

Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002) [National Institutes of Health, United States]

Investigator Initiated Multi-Site Clinical Trials (Collaborative R01) (PAR-10-096) [National Institutes of Health, United States]

Expressions of Interest for Membership of the Therapeutic Goods Committee [Therapeutic Goods Administration, Australia]

2010 Bone Marrow Transplant (BMT) Tandem Meetings
February 24-28, 2010
Orlando, United States

36th Annual Meeting of the European Group for Blood & Marrow Transplantation (EBMT)
March 21-24, 2010
Vienna, Austria

12th Biennial Canadian Blood and Marrow Transplant Group (CBMTG) Conference
April 7-10, 2010
Vancouver, Canada

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
June 26-July 1, 2010
Berlin, Germany

Society for Hematology and Stem Cells (ISEH) 2010 Meeting
September 15-18, 2010
Melbourne, Australia

American Association of Blood Banks (AABB) Annual Meeting 2010
October 9-12, 2010
Baltimore, United States

52nd American Society of Hematology (ASH) Annual Meeting and Exposition
December 4-7, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

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