TOP STORY Blood Deficiencies are Strong Predictors of Poor Outcome For healthcare professionals diagnosing primary Sjogren’s Syndrome, the incidence of blood based deficiencies is the strongest predictor of a poor outcome in patients according to the results of a study. [Press release from EurekAlert! discussing research presented at the Annual Congress of the European League Against Rheumatism (EULAR 2010)]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Revised Map of the Human Progenitor Hierarchy Shows the Origin of Macrophages and Dendritic Cells in Early Lymphoid Development Here, researchers provide a comprehensive analysis of the human hematopoietic hierarchy by clonally mapping the developmental potential of seven progenitor classes from neonatal cord blood and adult bone marrow. [Nat Immunol] GSK-3 Promotes Conditional Association of CREB and Its Coactivators with MEIS1 to Facilitate HOX-Mediated Transcription and Oncogenesis Researchers demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. [Cancer Cell] Immature B Cell Progenitors Survive Oncogenic Stress and Efficiently Initiate Ph+ B-Acute Lymphoblastic Leukemia Researchers demonstrate that B cell progenitors up to and including the pro-B cell efficiently initiate Philadelphia chromosome positive (Ph+) B-acute lymphoblastic leukemia. [Blood] Modeling the Human 8p11-Myeloproliferative Syndrome in Immunodeficient Mice Here, researchers report that expression of ZMYM2/FGFR1 (previously known as ZNF198/FGFR1) or BCR/FGFR1 in normal human CD34+ cells from umbilical-cord blood leads to increased cellular proliferation and differentiation towards the erythroid lineage in vitro. [Blood] In Vitro and In Vivo. Advantages Over Bone Marrow-Derived Mesenchymal Stem Cells” target=”_blank” href=”http://ajp.amjpathol.org/cgi/content/abstract/ajpath.2010.091042v1″ alias=”C08 Adipose Tissue-Derived Mesenchymal Stem Cells Facilitate Hematopoiesis In Vitro and In Vivo
. Advantages Over Bone Marrow-Derived Mesenchymal Stem Cells” conversion=”false”>Adipose Tissue-Derived Mesenchymal Stem Cells Facilitate Hematopoiesis In Vitro and In Vivo. Advantages Over Bone Marrow-Derived Mesenchymal Stem Cells In this study, researchers extensively evaluated the hematopoiesis-supporting properties of adipose tissue-derived mesenchymal stem cells, which are largely unknown. [Am J Pathol] CLINICAL RESEARCH Effect of Graft Source on Unrelated Donor Hematopoietic Stem-Cell Transplantation in Adults with Acute Leukemia: A Retrospective Analysis Researchers aimed to determine the optimal role of umbilical-cord blood grafts in transplantation for adults with acute leukemia, and to establish whether current graft-selection practices are appropriate. [Lancet Oncol] Prognostic Impact of Monosomal Karyotype in Young Adult and Elderly Acute Myeloid Leukemia: The Southwest Oncology Group Experience Monosomal Karyotype (MK), defined as two or more monosomies, or a single monosomy in the presence of structural abnormalities, has recently been reported as identifying a distinct subset of acute myeloid leukemia (AML) patients with an extremely poor prognosis. In an effort to confirm this observation, researchers analyzed the prognostic impact of MK in 1344 AML patients between the ages of 16 and 88 years treated on Southwest Oncology Group protocols. [Blood] Monocyte Derivatives Promote Angiogenesis and Myocyte Survival in a Model of Myocardial Infarction In this study, researchers have investigated the hypothesis that previously reported beneficial effect of peripheral blood mononuclear cells cultured under angiogenic conditions on cardiovascular function following ischemia is not limited to EPCs but also to monocytes contained therein. [Cell Transplant] High Rate of Stem Cell Mobilization Failure after Thalidomide and Oral Cyclophosphamide Induction Therapy for Multiple Myeloma The results demonstrate that the combination of thalidomide and oral cyclophosphamide impairs stem cell mobilization and indicate that drugs with no previously reported relevant effect on stem cell mobilization can have a substantial impact when given in combination. [Bone Marrow Transplant]
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POLICY NEWS National Heart, Lung, and Blood Institute Funds Research to Improve Safety of Red Blood Cell Transfusions The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, is funding nine research grants to determine if the safety and efficacy of red blood cell transfusions vary depending on how long the cells have been stored. [National Institutes of Health, United States] New Videos Reveal How NIH Identifies the Most Promising Research Applications The National Institutes of Health’s Center for Scientific Review released a new video to show new applicants and others how NIH assesses over 80,000 grant applications each year to help find those with the most merit. [National Institutes of Health, United States] NIH and Wellcome Trust Announce Partnership to Support Genomic, Population-Based Studies in Africa The National Institutes of Health (NIH) and the Wellcome Trust announced a partnership with African researchers to conduct genetic and environmental studies in Africa of common, non-communicable disorders, such as heart disease and cancer, as well as communicable diseases, such as malaria. [National Institutes of Health, United States] Notice of Intent to Publish a Funding Opportunity Announcement for the Centers Program for Research on HIV/AIDS and Mental Health (P30) (NOT-MH-10-022) [National Institutes of Health, United States] Expanding and Personalizing Treatment Options for Alcohol Use Disorders Including Pharmacogenomics (R01) (PAS-10-215) [National Institutes of Health, United States] Increased Budget Limit for Applications Submitted in Response to PAR-09-135, Replication, Fine-Mapping and Sequencing: Follow-Up on Genome-Wide Association Studies for Arthritis and Musculoskeletal and Skin Diseases (R01) (NOT-AR-10-040) [National Institutes of Health, United States] Novel NeuroAIDS Therapeutics: Integrated Preclinical/Clinical Program (P01) (PAR-10-216) [National Institutes of Health, United States] July 26-27, 2010: Meeting of the Blood Products Advisory Committee Announcement [Food and Drug Administration, United States]
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EVENTS XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI) June 26-July 1, 2010 Berlin, Germany Translational Cancer Medicine 2010 – USA July 11-14, 2010 San Francisco, United States United Kingdom National Stem Cell Network (UKNSCN) Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences 2nd Annual World Biobanking Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland The European Molecular Biology Organization (EMBO) Meeting 2010 September 4-7, 2010 Barcelona, Spain International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States Society for Hematology and Stem Cells (ISEH) 2010 Meeting September 15-18, 2010 Melbourne, Australia Stem Cells and Regeneration October 3-9, 2010 Woods Hole, United States American Association of Blood Banks (AABB) Annual Meeting 2010 October 9-12, 2010 Baltimore, United States Fraunhofer Life Science Symposium Leipzig 2010 October 29-30, 2010 Leipzig, Germany 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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