Hematopoiesis News Volume 1.26 | Jul 13 2010

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    Hematopoiesis News 1.26, July 13, 2010.  
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Protein that Predicts Prognosis of Leukemia Patients May Also be a Therapeutic Target  ShareThis
    Researchers have identified a protein, called Musashi 2, that is predictive of prognosis in acute myeloid leukemia and chronic myeloid leukemia patients. [Press release from the Whitehead Institute for Biomedical Research discussing online prepublication in Nature Medicine]

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    SCIENCE NEWS

    Blood-Producing Stem Cells Explained
    A team of researchers have made significant progress in the understanding of hematopoietic stem cells. [Press release from the Institute for Research in Immunology and Cancer (IRIC) of the Université de Montréal discussing online prepublication in Cell Stem Cell]

    ‘Stem Cell Detectives’ Uncover Potential Cancer Cause
    Australian researchers have uncovered a new mutation in stem cells that may be linked to the development of leukemia, breast and colon cancer. [Press release from The Australian National University discussing online prepublication in Blood]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    LABORATORY RESEARCH

    Musashi-2 Regulates Normal Hematopoiesis and Promotes Aggressive Myeloid Leukemia
    Researchers demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. [Nat Med]

    A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal
    Researchers report that human hematopoietic stem cells exhibit delayed DNA double-strand break rejoining, persistent gammaH2AX foci, and enhanced p53- and ASPP1-dependent apoptosis after gamma-radiation compared to progenitors. [Cell Stem Cell]

    Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
    The results demonstrate that quiescence is a double-edged sword that renders hematopoietic stem cells intrinsically vulnerable to mutagenesis following DNA damage. [Cell Stem Cell]

    A Recessive Screen for Genes Regulating Hematopoietic Stem Cells
    Here, researchers demonstrate that chemical mutagenesis of mice combined with advances in hematopoietic stem cell reagents and genome resources can efficiently recover recessive mutations and identify genes essential for generation and proliferation of definitive hematopoietic stem cells and/or their progeny. [Blood]

    Trib1 Links the MEK1/ERK Pathway in Myeloid Leukemogenesis
    Researchers report that interaction between Trib1 and MEK1 is required for Trib1-induced leukemogenesis. [Blood]

    Kinetics and Specificity of FLVCR Export Function and its Dependence on Hemopexin
    Using 55Fe-heme and the fluorescent heme analog zinc mesoporphyrin, researchers investigated whether export by Feline Leukemia Virus Subgroup-C Receptor (FLVCR) depends on the availability and avidity of extracellular heme-binding proteins. [J Biol Chem]

    Essential Role of p400/mDomino Chromatin-Remodeling ATPase in Bone Marrow Hematopoiesis and Cell-Cycle Progression
    Here, researchers generated a conditional knockout mouse for the p400/mDomino gene, and investigated p400/mDomino’s role in adult bone marrow hematopoiesis and in the cell-cycle progression of embryonic fibroblasts. [J Biol Chem]

    CLINICAL RESEARCH

    Chemotherapy-Phased Imatinib Pulses Improve Long-Term Outcome of Adult Patients With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Northern Italy Leukemia Group Protocol 09/00
    Short imatinib pulses were added to chemotherapy to improve the long-term survival of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia, to optimize complete remission and stem-cell transplantation rates. [J Clin Oncol]

    Dynamic Single-Cell Network Profiles in Acute Myelogenous Leukemia (AML) Are Associated with Patient Response to Standard Induction Therapy
    Researchers applied single-cell network profiling (SCNP) using flow cytometry, a tool that allows a comprehensive functional assessment of intracellular signaling pathways in heterogeneous tissues, to two training cohorts of AML samples (n = 34 and 88) to predict the likelihood of response to induction chemotherapy. [Clin Cancer Res]

    INDUSTRY NEWS

    iPierian Closes $22 Million Series B Financing Led By Google Ventures
    iPierian, Inc., the leading biopharmaceutical company using patient-derived induced pluripotent stem cells for drug discovery, announced the closing of a $22 million Series B equity financing. [iPierian, Inc. Press Release]

    SPRYCEL® (Dasatinib) Receives FDA Priority Review for the Treatment of Adult Patients with Newly Diagnosed Chronic Myeloid Leukemia (CML) in Chronic Phase
    Bristol-Myers Squibb Company and Otsuka Pharmaceutical Co., Ltd. announced that the U.S. Food and Drug Administration has accepted for filing and review the supplemental New Drug Application for SPRYCEL® (dasatinib) for the treatment of adult patients with newly diagnosed chronic myeloid leukemia in chronic phase. [Bristol-Myers Squibb Company Press Release]

    White House’s Medicare Pick To Be Installed
    President Barack Obama plans to install his nominee to oversee Medicare and Medicaid, using a tactic aimed at averting a bitter fight in Congress. [The Wall Street Journal]

    POLICY NEWS

    Harold Varmus Sworn in as National Cancer Institute’s 14th Director
    Nobel Prize winner Harold E. Varmus, M.D., today took the oath of office to become the National Cancer Institute’s (NCI) 14th director. NCI is one of the 27 Institutes and Centers that comprise the National Institutes of Health (NIH). [National Institutes of Health, United States]

    Britain Delays Controversial Assessment Scheme for Research
    Britain’s new science minister made good a manifesto pledge today when he announced that the coalition government would delay for one year the implementation of the controversial Research Excellence Framework, a system of assessing university departments for the distribution of funding. [Ministry of Universities and Science, United Kingdom]

    Spanish Science Spending Lockdown
    Spain’s science and innovation minister said that research funding will be “frozen or minimally reduced” as a result of government-wide austerity measures. [Ministry of Science and Innovation, Spain]

    Maryland Stem Cell Research Commission Elects Margaret Conn Himelfarb as Chair
    The Maryland Stem Cell Research Commission announced that it has elected Margaret Conn Himelfarb as chair and Bowen P. Weisheit, Jr. as vice chair. [Maryland Stem Cell Research Commission, United States]

    Clinical Laboratory Improvement Advisory Committee (CLIAC); Notice of Meeting
    [Centers for Disease Control and Prevention, United States]

    Request for Information (RFI) on the National Institutes of Health Plan to Develop the Genetic Testing Registry; Notice [National Institutes of Health, United States]

    Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting [National Institutes of Health, United States]

    National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting [National Institutes of Health, United States]

    July 26-27, 2010: Blood Products Advisory Committee Meeting Waivers for Conflicts of Interest [Food and Drug Administration, United States]

    EVENTS

    Select Biosciences 3rd Annual Stem Cells Europe Conference
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences 2nd Annual World Biobanking Summit
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences Inaugural Cellular Therapy Summit
    August 24-25, 2010
    Edinburgh, Scotland

    The European Molecular Biology Organization (EMBO) Meeting 2010
    September 4-7, 2010
    Barcelona, Spain

    International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
    September 11-14, 2010
    Belgirate, Italy

    Stem Cells USA & Regenerative Medicine Congress 2010
    September 13-15, 2010
    Philadelphia, United States

    Society for Hematology and Stem Cells (ISEH) 2010 Meeting
    September 15-18, 2010
    Melbourne, Australia

    Sickle Cell Disease Association of America (SCDAA) 38th Annual Convention
    September 21-24, 2010
    Washington D.C., United States

    American Society of Hematology (ASH) State-of-the-Art Symposium 2010
    September 24-25, 2010
    Chicago, United States

    Society for the Advancement of Blood Management® (SABM®) 2010 Annual Meeting
    September 24-26, 2010
    San Juan, Puerto Rico

    Stem Cells and Regeneration
    October 3-9, 2010
    Woods Hole, United States

    American Association of Blood Banks (AABB) Annual Meeting 2010
    October 9-12, 2010
    Baltimore, United States

    Fraunhofer Life Science Symposium Leipzig 2010
    October 29-30, 2010
    Leipzig, Germany

    52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    December 4-7, 2010
    Orlando, United States

    Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.

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