Hematopoiesis News Volume 1.27 | Jul 20 2010

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    Hematopoiesis News 1.27, July 20, 2010.  
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Babraham Scientists Discover a New Mechanism Behind Leukemia  ShareThis
    New research revealed that mice missing two key genes develop an aggressive form of leukemia similar to acute lymphoblastic leukemia, the most common form of leukemia in children. [Press release from the Babraham Institute discussing online prepublication in Nature Immunology]

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    SCIENCE NEWS

    Patient’s ‘Lost’ Blood Can Be Reused in Trauma Surgery
    Reusing an injured patients’ own blood during emergency surgery costs less and avoids the risks associated with using donated blood for transfusions, new research suggests. [Press release from the Beth Israel Deaconess Medical Center discussing online prepublication in the Archives of Surgery]

    New Mechanism that Drives Development of B Lymphocytes in Bone Marrow Discovered
    Scientists have discovered a new mechanism that drives the development of B lymphocytes in the bone marrow. [The Medical News Press Release]

    Delay in Release of Study on Chronic Fatigue Syndrome Prompts an Outcry
    Researchers at the National Institutes of Health and the Food and Drug Administration, citing a need to re-evaluate their data, have delayed publication of a new study believed to provide evidence of a link between chronic fatigue syndrome and a little-known retrovirus. [The New York Times Press Release]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    LABORATORY RESEARCH

    Deletion of the RNA-Binding Proteins ZFP36L1 and ZFP36L2 Leads to Perturbed Thymic Development and T Lymphoblastic Leukemia
    Here, researchers show that mice that lacked ZFP36L1 and ZFP36L2 during thymopoiesis developed a T cell acute lymphoblastic leukemia-dependent on the oncogenic transcription factor Notch1. [Nat Immunol]

    Wnt/Ca2+/NFAT Signaling Maintains Survival of Ph+ Leukemia Cells Upon Inhibition of Bcr-Abl
    To identify genes whose inhibition sensitizes Bcr-Abl+ leukemias to killing by Bcr-Abl inhibitors, researchers performed an RNAi-based synthetic lethal screen with imatinib mesylate in chronic myeloid leukemia cells. [Cancer Cell]

    PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3 p88
    Researchers demonstrate that upon As2O3 exposure, PML undergoes reactive oxygen species-initiated intermolecular disulfide formation and binds arsenic directly. [Cancer Cell]

    Gene Amplification as Double Minutes or Homogeneously Staining Regions in Solid Tumors: Origin and Structure
    In the present paper researchers investigated 10 cell lines from solid tumors showing MYCN amplification as double minutes or homogeneously staining regions. [Genome Res]

    Immune Activation Induces Immortalization of HTLV-1 LTR-Tax Transgenic CD4+ T Cells
    Researchers suggest that immune activation of infected CD4+ T cells plays an important role in the induction of Tax expression, T cell proliferation, and pathogenesis of adult T cell leukemia/lymphoma in HTLV-1-infected individuals. [Blood]

    Drosophila Abelson Kinase Mediates Cell Invasion and Proliferation Through Two Distinct MAPK Pathways” target=”_blank” href=”http://www.nature.com/onc/journal/v29/n28/abs/onc2010155a.html” alias=”C07 Drosophila Abelson Kinase Mediates Cell Invasion and Proliferation Through Two Distinct MAPK Pathways” conversion=”false”>Drosophila Abelson Kinase Mediates Cell Invasion and Proliferation Through Two Distinct MAPK Pathways
    Using the Drosophila wing epithelium as an in vivo model system, researchers show that overexpression (activation) of Drosophila Abl (dAbl) causes loss of epithelial apical/basal cell polarity and secretion of matrix metalloproteinases, resulting in a cellular invasion and apoptosis. [Oncogene]

    CLINICAL RESEARCH

    Hematopoietic Stem Cell Transplantation for Acute Leukemia in Relapse or Primary Induction Failure
    Hematopoietic stem cell transplantation when a patient is not in complete remission is of uncertain benefit. Researchers hypothesized that pretransplantation variables may define subgroups that have a better prognosis. [J Clin Oncol]

    Induction of Complete and Molecular Remissions in Acute Myeloid Leukemia by Wilms’ Tumor 1 Antigen-Targeted Dendritic Cell Vaccination
    Here, in a phase I/II trial, researchers investigated the effect of autologous dendritic cell vaccination in 10 patients with acute myeloid leukemia. [Proc Natl Acad Sci U S A]

    INDUSTRY NEWS

    Scientists at the Samuel Waxman Cancer Research Foundation and the Shanghai Institute of Hematology Receive Grant to Eradicate the Leukemia Stem Cell
    A three-year grant of $375,000 from the Emerald Foundation, Inc. will further expand the collaboration between researchers from the Samuel Waxman Cancer Research Foundation (SWCRF) and researchers at the Shanghai Institute of Hematology. [Samuel Waxman Cancer Research Foundation Press Release]

    The Samuel Waxman Cancer Research Foundation Awards $1.54 Million in Research Grants for 2010-2011
    The Samuel Waxman Cancer Research Foundation has awarded 13 collaborative research grants and 3 individual research grants, totaling $1.54 million. [Samuel Waxman Cancer Research Foundation Press Release]

    ChemGenex and U.S. FDA Agree on Potential Regulatory Pathway for OMAPRO™
    ChemGenex Pharmaceuticals Limited announced it has agreed with the U.S. Food and Drug Administration a potential regulatory path to progress OMAPRO™ (omacetaxine mepesuccinate) for the treatment of patients with Chronic Myeloid Leukemia. [ChemGenex Pharmaceuticals Limited Press Release]

    Cell Therapeutics, Inc. (CTI) Signs Long-Term Manufacturing Agreement for Pixantrone With NerPharMa
    Cell Therapeutics (CTI) announced that it has signed a manufacturing agreement with NerPharMa DS (a pharmaceutical manufacturing company belonging to Nerviano Medical Sciences S.r.l. (“NerPharMa”), in Nerviano, Italy) for CTI’s drug candidate pixantrone. [Cell Therapeutics, Inc. Press Release]

    POLICY NEWS

    Ireland Keeps Light Shining on Science with New Spending
    In a surprise move, the Irish government (which is tottering on the brink of bankruptcy) announced that it would inject 359 million Euros into research. [Programme for Reseach in Third-Level Institutions, Ireland]

    Russian Researchers Call for Better Coordination of Science
    More than 2200 researchers sent an open letter to Russian President Dmitry Medvedev last week asking the government to set Russian science in order and to consult with the scientific community when making major science-policy decisions. [Russia]

    “Game Over” for British Science?
    The Royal Society and the British Academy strongly warned the British government that looming cuts to science funding could be “irreversibly catastrophic for the future of U.K. science and economic growth” if they go too far. [The Royal Society and the British Academy, United Kingdom]

    House Panel Approves 3.2% Raise for NIH in 2011
    A House of Representatives spending panel yesterday approved a $1 billion increase, to $32 billion, in the 2011 budget for the National Institutes of Health (NIH). [National Institutes of Health, United States]

    NIH Expands National Network for Transforming Clinical and Translational Research
    Nine health research centers have received funds to develop ways to reduce the time it takes for clinical research to become treatments for patients. The funds were awarded as part of the Clinical and Translational Science Awards program which is led by the National Center for Research Resources. [National Institutes of Health, United States]

    Prospective Grant of Exclusive License: The Development of Human Therapeutics for the Treatment of Cancer  [National Institutes of Health, United States]

    Pre-Application Meeting for Request for Applications (RFA-CA-10-016) for the Clinical Proteomic Technologies for Cancer Initiative (CPTC): Proteome Characterization Centers (NOT-CA-10-031) [National Institutes of Health, United States]

    Notice of Intent to Publish a Request for Applications for Tumor Microenvironment Network (TMEN) (NOT-CA-10-032) [National Institutes of Health, United States]

    Clarification of Additional Research Objectives for NICHD PAR-08-138, Genetic Screens to Enhance Zebrafish Research (R01) (NOT-HD-10-015) [National Institutes of Health, United States]

    Notice of Expiration of Biomedical Technology Research Resource (PAR-08-259) and Reissuance of Biomedical Technology Research Center (P41)(PAR-10-225) (NOT-RR-10-011) [National Institutes of Health, United States]

    2011 NIH Directors New Innovator Award Program (DP2) (RFA-RM-10-009) [National Institutes of Health, United States]

    EVENTS (Listed by Date)

    Select Biosciences 3rd Annual Stem Cells Europe Conference
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences 2nd Annual World Biobanking Summit
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences Inaugural Cellular Therapy Summit
    August 24-25, 2010
    Edinburgh, Scotland

    The European Molecular Biology Organization (EMBO) Meeting 2010
    September 4-7, 2010
    Barcelona, Spain

    International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
    September 11-14, 2010
    Belgirate, Italy

    Stem Cells USA & Regenerative Medicine Congress 2010
    September 13-15, 2010
    Philadelphia, United States

    Society for Hematology and Stem Cells (ISEH) 2010 Meeting
    September 15-18, 2010
    Melbourne, Australia

    Sickle Cell Disease Association of America (SCDAA) 38th Annual Convention
    September 21-24, 2010
    Washington D.C., United States

    American Society of Hematology (ASH) State-of-the-Art Symposium 2010
    September 24-25, 2010
    Chicago, United States

    Society for the Advancement of Blood Management® (SABM®) 2010 Annual Meeting
    September 24-26, 2010
    San Juan, Puerto Rico

    Stem Cells and Regeneration
    October 3-9, 2010
    Woods Hole, United States

    American Association of Blood Banks (AABB) Annual Meeting 2010
    October 9-12, 2010
    Baltimore, United States

    Fraunhofer Life Science Symposium Leipzig 2010
    October 29-30, 2010
    Leipzig, Germany

    52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    December 4-7, 2010
    Orlando, United States

    NEW Highlights of American Society of Hematology (ASH) Vancouver
    January 21-22, 2011
    Vancouver, Canada

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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