Hematopoiesis News Volume 1.32 | Aug 24 2010

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    Hematopoiesis News 1.33, August 31, 2010.  
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Early Mammalian Erythropoiesis Requires the Dot1L Methyltransferase  ShareThis
    Researchers analyzed Dot1L mutant mice to determine the influence of this enzyme on embryonic hematopoiesis. [Blood]


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    SCIENCE NEWS

    Human Umbilical Cord Blood Cells Aid Lab Animal Brain Cell Survival After Simulated Stroke
    Human umbilical cord blood cells used to treat cultured rat brain cells deprived of oxygen appear to protect astrocytes from cell death after stroke-like damage. [Press release from EurekAlert! discussing online prepublication in Stem Cell Reviews and Reports]

    CAS Chemistry Research Report: A Decade Later Human Genome Discoveries Spur Growth of Cancer Treatments
    Leukemia patients who have struggled with cancer therapy resistance and intolerance will now have more options thanks to targeted drug therapy. Such new treatment options are due, in part, to a rapid increase in journal and patent publications following the discovery of Gleevec. [Chemical Abstracts Service Press Release]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    LABORATORY RESEARCH

    Tissue Transglutaminase Contributes to the All-Trans Retinoic Acid Induced Differentiation Syndrome Phenotype in the NB4 Model of Acute Promyelocytic Leukemia
    Researchers propose that reduced expression of transglutaminase 2 in differentiating acute promyelocytic leukemia cells may suppress effector functions of neutrophil granulocytes and attenuate the all-trans -retinoic acid-induced inflammatory phenotype of differentiation syndrome. [Blood]

    Hedgehog Signaling Maintains Chemoresistance in Myeloid Leukemic Cells
    In this study, researchers show that the chemotherapy-resistant phenotype of myeloid leukemia cells correlates with activation of the Hedgehog pathway, whereas in chemosensitive cells, such activation is less pronounced. [Oncogene]

    A Functional SUMO-Interacting Motif in the Transactivation Domain of c-Myb Regulates its Myeloid Transforming Ability
    Using both a myeloid cell line-based assay and a primary hematopoietic cell assay, researchers addressed the transforming abilities of SUMO binding and conjugation mutants. [Oncogene]

    Arsenic Trioxide Induces Apoptosis through JNK and ERK in Human Mesothelioma Cells
    These results indicated that As2O3 induces apoptosis of NCI-H2052 cells mainly through JNK1/2 activation, and that ERK1/2 is involved in As2O3-induced apoptosis when JNK1/2 are inactivated. [J Cell Physiol]

    Regulation of the PML Tumor Suppressor in Drug-Induced Senescence of Human Normal and Cancer Cells by JAK/STAT-Mediated Signaling
    Here, researchers show that genotoxic drugs that induce senescence, such as 5-bromo-2’deoxyuridine, thymidine, distamycin A, aphidicolin, etoposide and camptothecin all evoke expansion of Promyelocytic leukemia protein nuclear compartment and its association with persistent DNA lesions in several human cancer cell lines and normal diploid fibroblasts. [Cell Cycle]

    Prospective Evaluation of Allogeneic Hematopoietic Stem-Cell Transplantation From Matched Related and Matched Unrelated Donors in Younger Adults With High-Risk Acute Myeloid Leukemia: German-Austrian Trial AMLHD98A
    This study assesses the impact of allogeneic hematopoietic stem-cell transplantation from matched related donors and matched unrelated donors on outcome in high-risk patients with acute myeloid leukemia within a prospective multicenter treatment trial. [J Clin Oncol]

    Prognosis of Binet Stage A Chronic Lymphocytic Leukemia Patients: The Strength of Routine Parameters
    Researchers propose an easy, fast, cost-effective strategy for a trustworthy prognostication in stage A patients, who currently represent over 80% of the chronic lymphocytic leukemia population, allowing physicians to adapt follow-up individually. [Blood]

    Th17 Immune Responses Contribute to the Pathophysiology of Aplastic Anemia
    Th17 immune responses contribute to aplastic anemia pathohysiology, especially at the early stage during disease progression. [Blood]

    Treatment of Patients with Relapsed/Refractory Multiple Myeloma with Lenalidomide and Dexamethasone With or Without Bortezomib: Prospective Evaluation of the Impact of Cytogenetic Abnormalities and of Previous Therapies
    Researchers prospectively studied the impact of several cytogenetic abnormalities in patients with relapsed/refractory myeloma who received lenalidomide and dexamethasone with or without the addition of bortezomib. [Leukemia]


    INDUSTRY NEWS

    Cerus Signs Agreement to Acquire INTERCEPT Blood System Asian Commercial Rights from BioOne
    Cerus Corporation announced that it has signed an agreement to acquire BioOne Corporation’s commercialization rights for the INTERCEPT Blood System for platelets and plasma, subject to approval of the transaction by BioOne’s shareholders. [Cerus Corporation Press Release]

    Isotechnika Pharma and 3SBio Announce Strategic Partnership to Develop and Commercialize Voclosporin in China
    Isotechnika Pharma Inc. and 3SBio Inc. announced the signing of a development and commercialization agreement for voclosporin, a next generation calcineurin inhibitor being developed for use in the prevention of organ rejection following transplantation and the treatment of autoimmune diseases. [Isotechnika Pharma Inc. Press Release]

    Sanofi’s Bid to Block Lovenox Copy Denied by Judge
    Sanofi-Aventis SA’s request to bar the U.S. Food and Drug Administration from allowing sales of a generic rival to its Lovenox blood thinner was rejected by a federal judge. [Businessweek]


    POLICY NEWS

    Court Sides With State in Baby Blood Storage Case
    Minnesota did not violate families’ privacy rights by collecting and storing children’s blood samples, the state Court of Appeals ruled. [Counthouse News Service]

    NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants
    National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States]

    NIH Director’s Response to Stem Cell Injunction [National Institutes of Health, United States]

    Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20861) [National Institutes of Health, United States]

    Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-21357) [National Institutes of Health, United States]

    National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-21282) [National Institutes of Health, United States]

    National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-21317) [National Institutes of Health, United States]

    National Human Genome Research Institute; Notice of Meetings (FR Doc. 2010-20858) [National Institutes of Health, United States]

    National Center for Research Resources; Notice of Closed Meeting (FR Doc. 2010-21280) [National Institutes of Health, United States]


    EVENTS (Listed by Date)

    The European Molecular Biology Organization (EMBO) Meeting 2010
    September 4-7, 2010
    Barcelona, Spain

    International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
    September 11-14, 2010
    Belgirate, Italy

    Stem Cells USA & Regenerative Medicine Congress 2010
    September 13-15, 2010
    Philadelphia, United States

    Society for Hematology and Stem Cells (ISEH) 2010 Meeting
    September 15-18, 2010
    Melbourne, Australia

    Sickle Cell Disease Association of America (SCDAA) 38th Annual Convention
    September 21-24, 2010
    Washington D.C., United States

    American Society of Hematology (ASH) State-of-the-Art Symposium 2010
    September 24-25, 2010
    Chicago, United States

    Society for the Advancement of Blood Management® (SABM®) 2010 Annual Meeting
    September 24-26, 2010
    San Juan, Puerto Rico

    Stem Cells and Regeneration
    October 3-9, 2010
    Woods Hole, United States

    American Association of Blood Banks (AABB) Annual Meeting 2010
    October 9-12, 2010
    Baltimore, United States

    Fraunhofer Life Science Symposium Leipzig 2010
    October 29-30, 2010
    Leipzig, Germany

    52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    December 4-7, 2010
    Orlando, United States

    Highlights of American Society of Hematology (ASH) Vancouver
    January 21-22, 2011
    Vancouver, Canada

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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