TOP STORY Gene Identified That Prevents Stem Cells From Turning Cancerous New research shows that having too many stem cells, or stem cells that live for too long, can increase the odds of developing cancer. By identifying a mechanism that regulates programmed cell death in hematopoietic stem cells, the work is the first to connect the death of such cells to a later susceptibility to tumors in mice.[Press release from Rockefeller University discussing online prepublication in Genes and Development]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Sept4/ARTS Is Required for Stem Cell Apoptosis and Tumor Suppression Here, researchers show that deletion of the mouse Sept4 gene, which encodes the inhibitor of apoptosis protein antagonist ARTS, promotes tumor development. [Genes Dev] Notch Signaling Is a Critical Regulator of Allogeneic CD4+ T Cell Responses Mediating Graft-Versus-Host Disease Results identify Notch as a novel essential regulator of pathogenic CD4+ T cell responses during acute graft-versus-host disease and suggest that Notch signaling in T cells should be investigated as a therapeutic target following allogeneic hematopoietic stem cell transplantation. [Blood] Aberrant Global Methylation Patterns Affect the Molecular Pathogenesis and Prognosis of Multiple Myeloma Researchers have used genome-wide methylation microarrays to analyze differences in CpG methylation patterns in cells relevant to the pathogenesis of myeloma plasma cells, including B cells, normal plasma cells, MGUS, presentation myeloma, and plasma cell leukemia. [Blood] Chemoproteomics-Based Kinome Profiling and Target Deconvolution of Clinical Multi-Kinase Inhibitors in Primary Chronic Lymphocytic Leukemia Cells Researchers profiled a panel of clinical multi-kinase inhibitors for their ability to induce apoptosis in primary chronic lymphocytic leukemia cells. [Leukemia] Arsenic-Induced, SUMO-Dependent Recruitment of RNF4 Into PML Nuclear Bodies Here, researchers analyzed the nuclear trafficking dynamics of promyelocytic leukemia and its SUMO-dependent ubiquitin E3 ligase, RNF4 in response to arsenic. [Mol Biol Cell] Oncoprotein Cot1 Represses Kinase Suppressors of Ras1/2 and 1,25-Dihydroxyvitamin D3-Induced Differentiation of Human Acute Myeloid Leukemia Cells Here, researchers show that the product of protooncogene Cot1 represses the monocytic phenotype in human acute myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3 (1,25D), even though the expression of cellular Cot1 increases early in the process of 1,25D-induced differentiation. [J Cell Physiol] CLINICAL RESEARCH Immune Reconstitution After Haploidentical Hematopoietic Cell Transplantation: Impact of Reduced Intensity Conditioning and CD3/CD19 Depleted Grafts Researchers report on 28 patients after haploidentical hematopoietic cell transplantation with CD3/CD19-depleted grafts using reduced intensity conditioning, which were prospectively evaluated for engraftment and immune reconstitution. [Leukemia]
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POLICY NEWS European Medicines Agency Strengthens Rules on Conflicts of Interests of Its Scientific Experts The European Medicines Agency has published new rules on how the Agency will be handling potential conflicts of interests of its scientific experts, following endorsement by its Management Board. [European Medicines Agency, European Union] IQWiG: Law Must Prescribe Obligation to Publish All Clinical Trials If the currently discussed draft on the “Law on the Reorganization of the Pharmaceutical Market” (AMNOG) is implemented, drug manufacturers will in future have to register their clinical trials at inception and publish results after completion. [Institute for Quality and Efficiency in Health Care (IQWiG), Germany] Loss of UK Genetics Public Bodies Confirmed The official announcement from the UK Government on the future of non-departmental public bodies has confirmed the rumored abolition of a total of 192 public bodies, with a further 118 to be merged. [Foundation for Genomics and Population Health, United Kingdom] More Legal Jousting in Stem Cell Case The two sides in the ongoing court battle over stem cell research filed another batch of legal documents in response to court-ordered deadlines. [Court of Appeals, United States] HHS to Let Secretary’s Genetics Committee Expire The Secretary’s Advisory Committee on Genetics, Health, and Society will disband next month, eight years after its founding. The committee had completed its original task, advising the Department of Health and Human Services (HHS) on a number of issues related to genomics. [Department of Health and Human Services, United States] Advisory Council on Blood Stem Cell Transplantation; Notice of Meeting (FR Doc. 2010-25646) [Department of Health and Human Services, United States] Screening Framework Guidance for Providers of Synthetic Double-Stranded DNA (FR Doc. 2010-25728) [Department of Health and Human Services, United States] Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational Science Awards (CTSA) Initiative (FR Doc. 2010-25589) [Department of Health and Human Services, United States] Agency Information Collection Request. 30-Day Public Comment Request (FR Doc. 2010-25587) [Department of Health and Human Services, United States] Partnerships To Advance the National Occupational Research Agenda (NORA) (FR Doc. 2010-25973) [Centers for Disease Control and Prevention, United States] Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States]
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EVENTS (Listed by Date) 6th Modern Drug Discovery & Development Summit (M3D) October 20-22, 2010 San Francisco, United States American Institute for Cancer Research (AICR) 2010 Annual Cancer Research Conference October 21-22, 2010 Washington, DC, United States Fraunhofer Life Science Symposium Leipzig 2010 October 29-30, 2010 Leipzig, Germany NEW 5th UK Cancer Stem Cell Symposium November 2, 2010 London, United Kingdom 9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research November 7-10, 2010 Philadelphia, United States 22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics November 16-19, 2010 Berlin, Germany 9th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases November 17-19, 2010 Sonoma, United States 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States NEW 5th Annual Stem Cell Meeting on the Mesa December 7, 2010 La Jolla, United States Highlights of American Society of Hematology (ASH) Vancouver January 21-22, 2011 Vancouver, Canada Highlights of American Society of Hematology (ASH) Washington, DC January 28-29, 2011 Washington, DC, United States Highlights of American Society of Hematology (ASH) San Francisco January 28-29, 2011 San Francisco, United States Highlights of American Society of Hematology (ASH) New York February 4-5, 2011 New York, United States Highlights of American Society of Hematology (ASH) San Diego February 4-5, 2011 San Diego, United States BMT Tandem Meetings (ASBMT/CIBMTR) February 17-21, 2011 Honolulu, Hawaii NEW Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment February 23-25, 2011 San Francisco, United States American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada Keystone Symposia: Hematopoiesis March 27-April 1, 2011 Big Sky, United States American Association for Cancer Research (AACR) 102nd Annual Meeting 2011 April 2-6, 2011 Orlando, United States 37th Annual Meeting of the European Group for Blood and Marrow Transplantation April 3-6, 2011 Paris, France International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES Clean Room Team Leader – Cellular Therapy (Cell Medica Limited) Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News at no cost. Visit here to post your career opportunities. Have we missed an important article or publication in Hematopoiesis News? Click here to submit! Comments or Suggestions? Email info@connexoncreative.com with your feedback.
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