SCIENCE NEWS Researchers Discover Key Mutation in Acute Myeloid Leukemia Researchers have discovered mutations in a particular gene that affects the treatment prognosis for some patients with acute myeloid leukemia. [Press release from the National Institutes of Health discussing online prepublication in The New England Journal of Medicine] Arsenic Early in Treatment Improves Survival for Leukemia Patients Arsenic has a significant positive effect on the survival of patients with acute promyelocytic leukemia, when administered after standard initial treatment, according to a new, multi-center study. [Press release from the Wake Forest University Baptist Medical Center discussing online prepublication in Blood] Mathematical Model of Red Blood Cells May Predict Risk of Anemia A collaboration between a physician-researcher at Massachusetts General Hospital and a mathematician from Harvard University has led to development of a mathematical model reflecting how red blood cells change in size and hemoglobin content during their four-month lifespan. [Press release from Harvard School of Engineering and Applied Science discussing online prepublication in the Proceedings of the National Academy of Sciences USA]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) LABORATORY RESEARCH Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors Via Dampening of ROS-Induced p53 Activity In the absence of Mdm2, stable p53R172P induced reactive oxygen species and cell cycle arrest, senescence, and cell death in the hematopoietic compartment. [Cell Stem Cell] The Orphan Nuclear Receptor Nurr1 Restricts the Proliferation of Hematopoietic Stem Cells The findings provide critical insight into the transcriptional control mechanisms that determine whether hematopoietic stem cells remain dormant or enter the cell cycle and begin to proliferate. [Nat Cell Biol] Cannabinoid Receptor 2 and its Agonists Mediate Hematopoiesis and Hematopoietic Stem and Progenitor Cell Mobilization Here, researchers show that bone marrow stromal cells express endocannabinoids (anandamide and 2-arachidonylglycerol), while CB2 receptors are expressed in human and murine hematopoietic stem and progenitor cells. [Blood] Pharmacologic Modulation of the Calcium-Sensing Receptor Enhances Hematopoietic Stem Cell Lodgment in the Adult Bone Marrow Using a calcium-sensing receptor (CaR) agonist, Cinacalcet, researchers assessed the effects of stimulating the CaR on the function of murine hematopoietic stem cells. [Blood] Structure of the Leukemia Oncogene LMO2: Implications for the Assembly of a Hematopoietic Transcription Factor Complex The results together with molecular docking and analysis of evolutionarily conserved residues yield the first structural model of the DNA binding complex containing LMO2, LDB1, SCL/TAL1 and GATA-1. [Blood] PD-L1 Blockade Effectively Restores Strong Graft-Versus-Leukemia Effects Without Graft-Versus-Host-Disease After Delayed Adoptive Transfer of T Cell Receptor Gene-Engineered Allogeneic CD8+ T Cells Researchers investigated whether the use of MHC-mismatched T cells would prolong the in vivo persistence of tumor-reactive T cell receptor gene expressing T cells by continuous antigen-driven proliferation via the endogenous potentially alloreactive receptor. [Blood] Building Multifunctionality Into a Complex Containing Master Regulators of Hematopoiesis The demonstration that non-DNA binding components ETO2 and LIM domain protein LMO2 exert qualitatively distinct functions at endogenous loci illustrates how components of complexes containing master developmental regulators can impart the capacity to regulate unique cohorts of target genes, thereby diversifying complex function. [Proc Natl Acad Sci USA] Physiological and Pathological Population Dynamics of Circulating Human Red Blood Cells Researchers used theory from statistical physics and data from the hospital clinical laboratory [d’Onofrio G, et al. (1995) Blood 85:818-823] to develop a master equation model for red blood cell maturation and clearance. [Proc Natl Acad Sci USA] The E2A-HLF Oncogenic Fusion Protein Acts Through Lmo2 and Bcl-2 to Immortalize Hematopoietic Progenitors The oncogenic fusion protein E2A-HLF is a chimeric transcription factor that arises from the t(17;19) translocation in childhood B cell acute lymphoblastic leukemias and is associated with very poor outcome. Researchers show that retroviral-mediated expression of E2A-HLF alone is sufficient to immortalize primary lymphoid progenitors. [Leukemia] CLINICAL RESEARCH Immunosuppressive CD14(+)HLA-DR(low/neg) Monocytes in B Cell Non-Hodgkin’s Lymphoma Researchers examined the immunophenotype of 40 non-Hodgkin’s lymphoma patients and 27 age-matched controls to better understand systemic immune suppression. [Blood] The Different Extent of B and T Cell Immune Reconstitution after Hematopoietic Stem Cell Transplantation and Enzyme Replacement Therapies in SCID Patients with Adenosine Deaminase Deficiency The mobilization of T cell receptor excision circle+ cells, though lower than in controls, was stable with time after hematopoietic stem cell transplantation treatment, leading to a constant peripheral T cell number and to the diversification of the T cell repertoire; however, it was compromised in children receiving prolonged enzyme replacement therapy with pegylated bovine adenosine deaminase, whose T cells showed progressively narrowing T cell repertoires. [ J Immunol]
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EVENTS (Listed by Date) 9th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases November 17-19, 2010 Sonoma, United States 52nd American Society of Hematology (ASH) Annual Meeting and Exposition December 4-7, 2010 Orlando, United States 5th Annual Stem Cell Meeting on the Mesa December 7, 2010 La Jolla, United States NEW The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine December 17-19, 2010 Guangzhou, China Highlights of American Society of Hematology (ASH) Vancouver January 21-22, 2011 Vancouver, Canada Highlights of American Society of Hematology (ASH) Washington, D.C. January 28-29, 2011 Washington, D.C., United States Highlights of American Society of Hematology (ASH) San Francisco January 28-29, 2011 San Francisco, United States Highlights of American Society of Hematology (ASH) New York February 4-5, 2011 New York, United States Highlights of American Society of Hematology (ASH) San Diego February 4-5, 2011 San Diego, United States BMT Tandem Meetings (ASBMT/CIBMTR) February 17-21, 2011 Honolulu, Hawaii Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment February 23-25, 2011 San Francisco, United States American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer March 3-6, 2011 Vancouver, Canada Keystone Symposia: Hematopoiesis March 27-April 1, 2011 Big Sky, United States United Kingdom National Stem Cell Network 2011 Annual Scientific Conference March 30-April 1, 2011 York, United Kingdom American Association for Cancer Research (AACR) 102nd Annual Meeting 2011 April 2-6, 2011 Orlando, United States 37th Annual Meeting of the European Group for Blood and Marrow Transplantation April 3-6, 2011 Paris, France International Society for Stem Cell Research (ISSCR) 9th Annual Meeting June 15-18, 2011 Toronto, Canada Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community. JOB OPPORTUNITIES Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies) Lab Technologist – Tissue Culture (STEMCELL Technologies) Product Manager – Pluripotent Stem Cells (STEMCELL Technologies) Business Manager – Centre for Blood Cell Therapies (Cell Therapies) Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News at no cost. Visit here to post your career opportunities.
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