Hematopoiesis News Volume 10.32 | Aug 20 2019

TOP STORY

Resveratrol Trimer Enhances Gene Delivery to Hematopoietic Stem Cells by Reducing Antiviral Restriction at Endosomes

Scientists showed that temporary co-application of the cyclic resveratrol trimer caraphenol A enhances lentiviral vector gene delivery efficiency to human and non-human primate hematopoietic stem and progenitor cells. [Blood] Abstract

(Ranked by impact factor of the journal)

PTPσ Inhibitors Promote Hematopoietic Stem Cell Regeneration

Researchers describe small molecule inhibitors of protein tyrosine phosphatase-sigma (PTPσ) that promote HSC regeneration in vivo. Systemic administration of the PTPσ inhibitor, DJ001, or its analog, to irradiated mice promoted HSC regeneration, accelerated hematologic recovery, and improved survival. [Nat Commun] Full Article

Runx1 Promotes Murine Erythroid Progenitor Proliferation and Inhibits Differentiation by Preventing Pu.1 Downregulation

Investigators identified the actions of Runx1 and Pu.1 itself at the Pu.1 gene upstream regulatory element as major regulators of Pu.1 expression in burst-forming unit erythrocytes. [Proc Natl Acad Sci USA] Abstract

Targeted Integration and High-Level Transgene Expression in AAVS1-Transgenic Mice after In Vivo Hematopoietic Stem Cell Transduction with HDAd5/35++ Vectors

The authors tested the HDAd-CRISPR + HDAd-donor vector system in AAVS1 transgenic mice using a standard ex vivo HSC gene therapy approach as well as in a new in vivo HSC transduction approach that involved HSC mobilization and intravenous HDAd5/35++ injections. [Mol Ther] Abstract | Graphical Abstract

m⁶A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment

Using single-cell RNA sequencing in combination with transcriptomic profiling of hematopoietic stem and progenitor cells from control and m⁶A methyltransferase Mettl3 conditional knockout mice, scientists found that m⁶A-deficient HSCs failed to symmetrically differentiate. [Cell Rep] Full Article | Graphical Abstract

TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human Vγ9Vδ2 T Cells

The authors analyzed the CDR3 of the TCR of human blood and thymic Vγ9Vδ2 T cells from fetal until adult life. They first identified key differences in the CDR3 repertoire of fetal and adult blood Vγ9Vδ2 T cells, including in CDR3 features important for phosphoantigen reactivity. [J Immunol] Abstract

The Low Toxicity of Graphene Quantum Dots Is Reflected by Marginal Gene Expression Changes of Primary Human Hematopoietic Stem Cells

Investigators report the effects of graphene quantum dots on the transcriptome of CD34⁺ HSCs after an incubation time of 36 hours. [Sci Rep] Full Article

Bmi1 Restricts the Adipogenic Differentiation of Bone Marrow Stromal Cells to Maintain the Integrity of the Hematopoietic Stem Cell Niche

Bmi1 deletion promoted the adipogenic differentiation of leptin receptor⁺ stromal cells and caused progressive fatty changes in the bone marrow (BM) of limb bones with age, resulting in reductions in the numbers of HSCs and progenitors in BM and enhanced extramedullary hematopoiesis. [Exp Hematol] Abstract

CLINICAL RESEARCH

Haploidentical vs. Unrelated Allogeneic Stem Cell Transplantation for Acute Lymphoblastic Leukemia in First Complete Remission: On Behalf of the ALWP of the EBMT

The outcomes of 1234 adult patients with ALL in first complete remission who underwent allogeneic stem cell transplantation between 2007 and 2016 were analyzed. Comparison was done between haploidentical donor, matched unrelated donor, and mismatched unrelated donor. [Leukemia] Full Article

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3D Chromosomal Landscapes in Hematopoiesis and Immunity

The authors summarize the current principles of 3D chromatin organization, how the integrity of the 3D genome governs immune cell development and malignant transformation, as well as how underlying (epi-)genetic drivers of 3D chromatin alterations might act as potential novel therapeutic targets for hematological malignancies. [Trends Immunol] Abstract

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Calquence Granted US Breakthrough Therapy Designation for Chronic Lymphocytic Leukemia

AstraZeneca announced that the FDA granted Breakthrough Therapy Designation for Calquence as a monotherapy treatment for adult patients with chronic lymphocytic leukaemia, one of the most common types of leukemia in adults. [Astrazeneca] Press Release

UChicago Medicine Oncologist to Receive Prestigious Medal for Leukemia Research

For his pioneering hematology research, University of Chicago Medicine oncologist and professor Richard A. Larson, MD, will receive the 2019 Henry M. Stratton Medal from the American Society of Hematology. [The University of Chicago Medicine] Press Release

Brazil’s Budget Cuts Threaten More Than 80,000 Science Scholarships

Brazil’s main science-funding agency will have to suspend more than 80,000 scholarships to postdoctoral researchers and graduate and undergraduate students starting in September unless it receives additional cash from the government. [Nature News] Editorial

The Push to Replace Journal Supplements with Repositories

Broken links, clunky formats, and outdated platforms have both authors and publishers turning to alternative solutions. [The Scientist] Editorial

NEW Cancer Evolution and Combinatorial Cancer Therapies: Concepts and Challenges
January 19-23, 2020
Keystone, Colorado, United States

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NEW Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Scholarship – Blood Cell Formation (Lund University)

Postdoctoral Positions – Stem Cell Biology, Cancer Biology, and Epigenetics (Baylor College of Medicine)

PhD Position – Epigenetic Heterogeneity and Dynamics in Acute Myeloid Leukemia (University of Newcastle)

Postdoctoral Position – Advanced Proteomics & Erythropoiesis (Lund University)

Faculty Positions – Center for Childhood Cancer and Blood Diseases (The Research Institute at Nationwide Children’s Hospital)

Senior Scientist – Immuno-Oncology of Hematologic Malignancies (University of Kansas School of Medicine)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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