Hematopoiesis News Volume 10.33 | Aug 27 2019

TOP STORY

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction

Scientists showed that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction but dramatically accumulated within the bone marrow, where they adopted a state associated with energy conservation. [Cell] Full Article | Graphical Abstract

(Ranked by impact factor of the journal)

Precision Mouse Models with Expanded Tropism for Human Pathogens

Researchers showed that implantation of human lung tissue, which contains up to 40 cell types, including nonhematopoietic cells, into immunodeficient mice (lung-only mice) resulted in the development of a highly vascularized lung implant. [Nat Biotechnol] Abstract

hCINAP Regulates the DNA-Damage Response and Mediates the Resistance of Acute Myelocytic Leukemia Cells to Therapy

Investigators found that hCINAP was involved in the repair of double-stranded DNA breaks (DSB) and that its expression correlated with acute myeloid leukemia prognosis. Following DSB, hCINAP was recruited to damage sites where it promoted SENP3-dependent deSUMOylation of NPM1. [Nat Commun] Full Article

TP53 Deficiency Permits Chromosome Abnormalities and Karyotype Heterogeneity in Acute Myeloid Leukemia

The authors generated isogenic TP53-knockout versions of the euploid acute myeloid leukemia cell line EEB to investigate the impact of TP53 on karyotype stability. They showed that chromosome abnormalities spontaneously arose in TP53-deficient cells. [Leukemia] Abstract

The FLT3-ITD Mutation and the Expression of Its Downstream Signaling Intermediates STAT5 and Pim-1 Are Positively Correlated with CXCR4 Expression in Patients with Acute Myeloid Leukemia

Scientists analyzed the relationship between chemokine receptor 4 (CXCR4) expression and the FLT3-ITD mutation in 466 patients with de novo AML to clarify the effect of FLT3-ITD mutations on CXCR4 expression in patients with AML. [Sci Rep] Full Article

Inhibition of GATA2 Restrains Cell Proliferation and Enhances Apoptosis and Chemotherapy Mediated Apoptosis in Human GATA2 Overexpressing AML Cells

By using shRNAi to target GATA2 in acute myeloid leukemia (AML) cell lines, and an AML cell line expressing normal levels of GATA2, the authors found that inhibition of GATA2 caused attenuated cell proliferation and enhanced apoptosis exclusively in AML cell lines that overexpressed GATA2. [Sci Rep] Full Article

Allogeneic Transplantation of Peripheral Blood Stem Cell Grafts Results in a Massive Decrease of Primitive Hematopoietic Progenitor Frequencies in Reconstituted Bone Marrows

Researchers comprehensively analyzed the CD34⁺ compartment in G-CSF-stimulated peripheral blood stem cell grafts of allogeneic donors, in bone marrow (BM) samples of the respective recipients four weeks after allogeneic HSC transplantation, and in BM samples of healthy donors. [Bone Marrow Transplant] Abstract

CLINICAL RESEARCH

Human Herpesvirus 6B and Lower Respiratory Tract Disease after Hematopoietic Cell Transplantation

Investigators tested bronchoalveolar lavage (BAL) fluid for human herpesvirus 6B DNA using polymerase chain reaction in allogeneic hematopoietic cell transplantation recipients who underwent a BAL for evaluation of lower respiratory tract disease from 1992 to 2015. [J Clin Oncol] Abstract

Allogeneic Stem Cell Transplantation Improves Survival in Relapsed Hodgkin Lymphoma Patients Achieving Complete Remission after Salvage Treatment

Researchers performed a retrospective multicenter analysis of 113 patients with refractory/relapsed classic Hodgkin lymphoma who had undergone allogeneic stem cell transplant in Argentina. [Bone Marrow Transplant] Abstract

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Upfront Autologous Hematopoietic Stem Cell Transplantation Consolidation for Patients with Aggressive B-Cell Lymphomas in First Remission in the Rituximab Era: A Systematic Review and Meta-Analysis

The authors perform a systematic review and meta-analysis to assess the totality of evidence pertaining to the efficacy of autologous HSC transplantation consolidation for patients with diffuse large B-cell lymphoma in first remission. [Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Sigilon Therapeutics Receives Orphan Drug Designation for SIG-001 for the Treatment of Hemophilia A

Sigilon Therapeutics announced it has received Orphan Drug Designation for SIG-001, an investigational therapy for hemophilia A that leverages Sigilon’s Shielded Living Therapeutics™ platform to implant cells engineered to produce stable blood plasma levels of factor VIII, a crucial clotting protein. [Sigilon Therapeutics, Inc.] Press Release

GSK Announces Positive Headline Results from the Pivotal DREAMM-2 Study for Multiple Myeloma

GlaxoSmithKline plc announced positive headline results from the pivotal DREAMM-2 open-label, randomized study of two doses of belantamab mafodotin. The 196 patients in the trial had relapsed multiple myeloma, were refractory to an immunomodulatory drug, a proteasome inhibitor, and to treatment with an anti-CD38 antibody. [GlaxoSmithKline plc] Press Release

Rocket Pharmaceuticals Announces Clearance from the Spanish Agency for Medicines and Health Products for the Phase II Registration-Enabling FANCOLEN-II Study of RP-L102 for Fanconi Anemia

Rocket Pharmaceuticals, Inc. announced clearance from the Spanish Agency for Medicines and Health Products to commence enrollment in the FANCOLEN-II Phase II registration-enabling study of RP-L102 for Fanconi anemia in Spain. [Rocket Pharmaceuticals, Inc.] Press Release

Genmab Announces Approval of DARZALEX^® (Daratumumab) in Frontline Multiple Myeloma in Japan

Genmab A/S announced that the Ministry of Health, Labor and Welfare in Japan has approved the use of daratumumab in combination with bortezomib, melphalan and prednisone for the treatment of patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant. [Genmab A/S] Press Release

IU School of Medicine Researcher Hal Broxmeyer Awarded IU President’s Medal

In recognition of his impact and influence, Indiana University (IU) President Michael A. McRobbie presented Hal Broxmeyer with the President’s Medal for Excellence, a rare honor which is awarded to individuals at IU for “outstanding academic, artistic or professional accomplishments or to individuals for exceptional service to the university.” [Indiana University] Press Release

Memo to Italy’s President: Your Researchers Need You

Italy’s coalition government ended abruptly, when the nationalist Lega party of deputy prime minister Matteo Salvini announced that it was walking away from its turbulent coalition with the anti-establishment M5S party, known as the Five Star Movement. The collapse is of great concern: a much-delayed funding increase is now on hold, and the political uncertainty adds further threat. [Nature News] Editorial

NSF Graduate Fellowships Disproportionately Go to Students at a Few Top Schools

As this year’s eligible students begin to labor over their applications, it’s worth asking why certain schools come away with dozens of winners each year—and what that means about the academy at large. [ScienceInsider] Editorial

NEW Cell Death in Immunity and Inflammation
October 6-9, 2019
Crete, Greece

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NEW Research Technologist (STEMCELL Technologies Inc.)

Scientific Communications Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Studies – Normal and Aberrant Hematopoiesis (Karolinska Institutet)

Postdoctoral Scholarship – Blood Cell Formation (Lund University)

Postdoctoral Positions – Stem Cell Biology, Cancer Biology, and Epigenetics (Baylor College of Medicine)

PhD Position – Epigenetic Heterogeneity and Dynamics in Acute Myeloid Leukemia (University of Newcastle)

Postdoctoral Position – Advanced Proteomics & Erythropoiesis (Lund University)

Faculty Positions – Center for Childhood Cancer and Blood Diseases (The Research Institute at Nationwide Children’s Hospital)

Senior Scientist – Immuno-Oncology of Hematologic Malignancies (University of Kansas School of Medicine)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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