Hematopoiesis News Volume 10.37 | Sep 24 2019

TOP STORY

NHEJ-Mediated Repair of CRISPR-Cas9-Induced DNA Breaks Efficiently Corrects Mutations in HSPCs from Patients with Fanconi Anemia

Researchers showed feasible correction of compromised functional phenotypes in hematopoietic cells from multiple Fanconi anemia (FA) complementation groups, including FA-A, FA-C, FA-D1, and FA-D2. [Cell Stem Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance

Scientists showed aryl hydrocarbon receptor (AHR) signaling was repressed in human acute myeloid leukemia blasts and preferentially downregulated in leukemic stem cell-enriched populations within leukemias. [Cancer Res] Abstract

Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells

CRISPR/Cas9 ribonucleoproteins, in combination with recombinant adeno-associated virus-DJ donor templates, led to gene knockin efficiencies of up to 30% in Lmnb1 and Actb loci of mouse hematopoietic stem and progenitor cells in vitro. [Cell Rep] Full Article | Graphical Abstract

Non-Hematopoietic STAT6 Induces Epithelial Tight Junction Dysfunction and Promotes Intestinal Inflammation and Tumorigenesis

Investigators demonstrated that non-hematopoietic STAT6, but not hematopoietic STAT6, triggered DSS-induced colitis and subsequent tumorigenesis. [Mucosal Immunol] Full Article

Biosafety Studies of a Clinically Applicable Lentiviral Vector for the Gene Therapy of Artemis-SCID

A lentiviral vector expressing physiological levels of human Artemis mRNA from an EF1a promoter without post-transcriptional regulation, was developed as a safe clinically applicable candidate for radiosensitive severe combined immunodeficiency (SCID) gene therapy. [Mol Ther Methods Clin Dev] Abstract | Full Article

Soluble Signals and Remodeling in a Synthetic Gelatin-Based Hematopoietic Stem Cell Niche

A library of methacrylamide-functionalized gelatin hydrogels was used to explore remodeling and crosstalk from mesenchymal stromal cells on the expansion and quiescence of murine HSCs. [Adv Healthc Mater] Abstract

Extracellular Annexin-A1 Promotes Myeloid/Granulocytic Differentiation of Hematopoietic Stem/Progenitor Cells via the Ca²⁺/MAPK Signaling Transduction Pathway

In in vitro studies, recombinant annexin A1 reduced both HSC and granulocyte-macrophage progenitor populations while enhancing mature cells. [Cell Death Discov] Full Article

The Inhibition of CD39 and CD73 Cell Surface Ectonucleotidases by Small Molecular Inhibitors Enhances the Mobilization of Bone Marrow Residing Stem Cells by Decreasing the Extracellular Level of Adenosine

The authorts report that pre-treatment of donor mice with CD39 and CD73 inhibitors facilitated the mobilization of hematopoietic stem progenitor cells as well as other types of bone marrow-residing stem cells. [Stem Cell Rev] Full Article

CLINICAL RESEARCH

Protective Effect of HLA-DPB1 Mismatch Remains Valid in Reduced-Intensity Conditioning Unrelated Donor Hematopoietic Cell Transplantation

Researchers retrospectively evaluated DP mismatch influence on hematopoietic cell transplantation (HCT) outcomes in 310 patients with high-resolution typing, who underwent reduced intensity conditioning HCT. [Bone Marrow Transplant] Abstract

Outcome in Patients with Diffuse Large B-Cell Lymphoma Who Relapse after Autologous Stem Cell Transplantation and Receive Active Therapy

Scientists present the results of a retrospective study of 256 adult patients reported to the European Society for Blood and Marrow Transplantation registry with diffuse large B-cell lymphoma who relapsed after autologous hematopoietic stem cell transplantation performed between 2003 and 2013, and who received active salvage strategies. [Bone Marrow Transplant] Abstract

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Revisiting NTRKs as an Emerging Oncogene in Hematological Malignancies

To assess the broader applicability for Trk inhibitors in hematological malignancies, the authors describe the current state of knowledge about alterations in the NTRK family in these disorders. [Leukemia] Full Article

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Roxadustat Approved in Japan for the Treatment of Anemia Associated with Chronic Kidney Disease in Dialysis Patients

FibroGen, Inc. and Astellas Pharma Inc. announced that Japan’s Ministry of Health, Labour and Welfare approved Evrenzo^® for the treatment of anemia associated with chronic kidney disease in dialysis patients. [FibroGen, Inc.] Press Release

Trovagene Announces Successful Completion of Phase Ib Trial of Onvansertib in Acute Myeloid Leukemia (AML) and Initiation of Patient Enrollment in Phase II

Trovagene, Inc. announced the successful completion of its Phase Ib trial of onvansertib in combination with standard-of-care chemotherapy in AML and initiation of patient enrollment in Phase II. [Trovagene, Inc.] Press Release

University of Minnesota Discovery Is Now a First-in-Human Clinical Trial for Leukemia

The discovery of tri-specific natural killer engagers, a combination protein that bridges an immune cell and a tumor cell to drive tumor cell killing power exponentially, has led to a new Phase I, first-in-human study to treat leukemia. [University of Minnesota (GlobeNewswire, Inc.)] Press Release

Grad Student Unions Dealt Blow as Proposed New Rule Says Students Aren’t ‘Employees’

Graduate students are not “employees” with a right to unionize, according to a rule proposed today by the National Labor Relations Board (NLRB), an agency that’s tasked with enforcing US labor laws. If implemented, the rule would undercut a recent wave of grad student unionization efforts at private US universities. The NLRB will be accepting public comment on the announcement for 60 days. [ScienceMagazine] Editorial

Kashmir’s Communication Blackout Is a ‘Devastating Blow’ for Academics, Researchers Say

Six professors from India’s top science institutions have appealed to the government to lift the blockade of academic and research institutions in Indian-controlled Kashmir. The blockade has been a “devastating blow,” the six write in an open letter published September 18^th. [ScienceMagazine] Editorial

NEW Keystone Symposia: Gene Regulation – From Mechanisms to Disease
January 26-30, 2020
Keystone, Colorado, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Scholar – Hematopoietic Cells (Penn State University)

NEW Postdoctoral Fellowship – Leukemia Pathogenesis (BC Cancer)

Research Technologist (STEMCELL Technologies Inc.)

Visiting Research Specialist – Hematopoietic Stem Cells (University of Illinois)

Faculty – Hematopoietic Biology and Malignancy (MD Anderson Cancer Center)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (University of Texas Southwestern)

Postdoctoral Scholar – Autologous Stem Cell Therapy (Stanford University)

Postdoctoral Scientist – Leukemia Microenvironment (Cedars-Sinai Medical Center)

Postdoctoral Scholarship – Blood Cell Formation (Lund University)

Postdoctoral Positions – Stem Cell Biology, Cancer Biology, and Epigenetics (Baylor College of Medicine)

Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

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