Hematopoiesis News 10.44 November 12, 2019 | |
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TOP STORYMechanistically, exercise diminished leptin production in adipose tissue, augmenting quiescence-promoting hematopoietic niche factors in leptin-receptor-positive stromal bone marrow cells. Induced deletion of the leptin receptor in Prrx1-creERT2; Leprfl/fl mice revealed that leptin’s effect on bone marrow niche cells regulated hematopoietic stem and progenitor cell proliferation and leukocyte production, as well as cardiovascular inflammation and outcomes. [Nat Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IL-27 Receptor-Regulated Stress Myelopoiesis Drives Abdominal Aortic Aneurysm Development Researchers report a pathogenic role for the interleukin-27 receptor (IL-27R) in abdominal aortic aneurysm (AAA), as genetic ablation of IL-27R protects mice from the disease development. Mitigation of AAA was associated with a blunted accumulation of myeloid cells in the aorta due to the attenuation of angiotensin II-induced HSC expansion. [Nat Commun] Full Article Protein Lysine 43 Methylation by EZH1 Promotes AML1-ETO Transcriptional Repression in Leukemia Enhancer of zeste homolog 1 (EZH1) knockdown impaired survival and proliferation of AML1-ETO-expressing cells in vitro and in vivo. Investigators found that EZH1 WD domain bound to the AML1-ETO NHR1 domain and methylated AML1-ETO at lysine 43. [Nat Commun] Full Article ATM Activity in T Cells is Critical for Immune Surveillance of Lymphoma In Vivo The authors showed that Atm reactivation in initially Atm-deficient B- and T cell lymphomas induced tumor regression. They further found a reduced T cell abundance in B cell lymphomas from Atm-defective mice and Ataxia-telangiectasia patients. Using T cell-specific Atm-knockout models, as well as allogeneic transplantation experiments, they pinpointed impaired immune surveillance as a contributor to cancer predisposition and development. [Leukemia] Abstract Investigators performed a systematic, mechanistic study of FTY720-induced cell death in acute myeloid leukemia (AML). They found that FTY720 induced cell death in a panel of genetically diverse AML cell lines that was accompanied by rapid phosphatidylserine externalization. [Cell Death Dis] Full Article The authors investigated whether low-dose irradiation before or after an antigen-antibody reaction has an anti-allergic effect. To test this, they activated rat basophilic leukemia mast cells with anti-2,4-dinitrophenyl IgE and 2,–dinitrophenyl human serum albumin, which served as an antigen. [Sci Rep] Full Article Researchers attempted to ameliorate the age-related decline in HSC function by modulating Bmi1 expression. The forced expression of Bmi1 did not attenuate myeloid-biased differentiation of aged HSCs. However, single cell transplantation assays revealed that the sustained expression of Bmi1 augmented the multi-lineage repopulating capacity of aged HSCs. [Biochem Biophys Res Commun] Abstract | Graphical Abstract CLINICAL RESEARCHThis single-arm, open-label, Phase I-II safety and feasibility study was done at two hospitals in Canada. In Part 1, patients received two cord blood units until UM171-expanded cord blood demonstrated engraftment. Once engraftment was documented researchers initiated Part 2, in which patients received a single UM171-expanded cord blood unit with a dose de-escalation design to determine the minimal cord blood unit cell dose that achieved prompt engraftment. [Lancet Haematol] Abstract Scientists analyzed the results of allo-HCT in patients with relapsed/refractory systemic anaplastic large cell lymphoma (sALCL) with special emphasis on the role of brentuximab vedotin (BV) as a bridge to allo-HCT. Forty-four patients with sALCL were included. Twenty-three patients received BV before allo-HCT; BV-treated patients were more heavily pre-treated. [Biol Blood Marrow Transplant] Abstract Donor and recipient blood groups were AB positive and 0 positive respectively, indicating a major ABO incompatibility. The patient was diagnosed with pure red-cell aplasia two months after allogeneic stem-cell transplantation. After failing multiple standard lines of treatment, compassionate treatment with daratumumab was requested. After receiving six doses of daratumumab, the patient had a marked reticulocyte response and consecutively become transfusion independent. [Eur J Haematol] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSThe authors report a case of life-threatening necrotizing fasciitis post HSC transplant, responding to the combination of antibiotics and daily transfusions of non-irradiated granulocyte colony stimulating factors (GCSF) stimulated leukocytes from healthy donors without surgical intervention. They also provide a concise review of the available literature regarding the use of this intervention, its efficacy and safety and comparison of irradiated with non-irradiated transfusions. [Bone Marrow Transplant] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSAVEO Oncology and Biodesix, Inc. announced the initiation of the CyFi-2 study, a randomized Phase II clinical study evaluating ficlatuzumab, AVEO’s potent hepatocyte growth factor inhibitory antibody product candidate, in combination with high-dose cytarabine vs. high-dose cytarabine alone in patients with relapsed and refractory acute myeloid leukemia (AML). [AVEO Oncology] Press Release AB8939 Receives Orphan Drug Designation for Acute Myeloid Leukemia from FDA AB Science SA announces that the FDA has granted the company Orphan Drug designation for compound AB8939 in the treatment of acute myeloid leukemia. [AB Science SA] Press Release Teneobio, Inc. announced that it has received orphan drug designation by the FDA for the treatment of multiple myeloma. [Teneobio, Inc.] Press Release | |
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POLICY NEWSMore South Korean Academics Caught Naming Kids as Co-Authors The number of South Korean academics accused of naming children as co-authors on research manuscripts — even though the children did not contribute to the research — continues to grow. [Nature News] Editorial What the Protests and Violence in Chile Mean for Science As universities shut down, researchers are demonstrating — and meeting with lawmakers to figure out if science can help solve socio-economic inequality. [Nature News] Editorial
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EVENTSNEW Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine) Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.) Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine) Associate/Professor – Hematology & Oncology (UC Davis School of Medicine) PhD Project – Physical Biology of Blood Stem Cells (University of York) Postdoctoral Fellowship (Versiti Blood Research Institute) Faculty Positions – Gene Editing (Indiana University School of Medicine) Postdoctoral Scholar – Hematopoietic Cells (Penn State University) Postdoctoral Fellowship – Leukemia Pathogenesis (BC Cancer) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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