Hematopoiesis News 11.03 January 28, 2020 | |
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TOP STORYLineage Tracing on Transcriptional Landscapes Links State to Fate During Differentiation The authors identified states of primed fate potential and located them on a continuous transcriptional landscape. They identified two routes of monocyte differentiation that left an imprint on mature cells. [Science] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers identified the conserved B4galt1 gene as a critical regulator of thrombopoiesis in megakaryocyte (MKs). β4GalT1 deficiency increased the number of fully differentiated MKs. However, the resulting lack of glycosylation enhances β1 integrin signaling leading to dysplastic MKs with severely impaired demarcation system formation and thrombopoiesis. [Nat Commun] Full Article The authors showed that nicotinamide phosphoribosyl-transferase (Nampt) blockage strongly ameliorated acute graft-versus-host disease (GVHD) and limited leukemic expansion. Nampt was highly elevated in serum of patients with gastrointestinal GVHD and was particularly abundant in human and mouse intestinal T cells. [Leukemia] Abstract | Press Release Scientists performed a comprehensive study of 200 adult patients with T-cell acute lymphoblastic leukemia (T-ALL) included in the GRAALL2003/2005 protocols to address the clinical significance of IL7Rp mutations. Next-generation sequencing of the IL7Rp revealed that IL7Rp mutations were frequent in adult T-ALL, particularly in immature/early T-cell progenitor-ALL. [Leukemia] Abstract To explore the potential risk stratification markers in this group of patients, the authors evaluated their genetic mutational landscape by a 35-gene myeloid neoplasm (MN)-focused next-generation sequencing panel and examined the association of mutations to progression of MNs. The study included 56 patients over a 10-year period with isolated del(20q), of whom 23 harbored at least one mutation. [Blood Cancer J] Full Article Scientists developed an experimental-analytical hybrid method, Quadratic phenotypic optimization platform (QPOP), which ranked drug combinations using a limited amount of tumor2. QPOP identified optimal combinations based on the observation that biological response to perturbations could be mapped to a second-order polynomial equation. [Blood Cancer J] Full Article Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism The authors compared human primary bone marrow adipocytes (BM-Ads) did not decrease in size compared to white adipocytes, suggesting they harbored unique metabolic properti with paired subcutaneous adipocytes (SC-ADs) using proteomic and lipidomic approaches. They found that that, although SC-Ads and BM-Ads shared similar morphological features, they possessed distinct lipid metabolism. [Cell Rep] Full Article | Graphical Abstract Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow Researchers present an unexpected role of vitamind D receptor (VDR) in normal hematopoiesis and in leukemogenesis. Limited VDR expression is associated with impaired myeloid progenitor differentiation and is a new prognostic factor in acute myeloid leukemia. In mice, the lack of Vdr resulted in increased numbers of hematopoietic and leukemia stem cells and quiescent hematopoietic stem cells. [Cell Rep] Full Article On-Chip Recapitulation of Clinical Bone Marrow Toxicities and Patient-Specific Pathophysiology Investigators showed that a vascularized human bone marrow (BM)-on-a-chip supported the differentiation and maturation of multiple blood cell lineages over four weeks while improving CD34+ cell maintenance, and that it recapitulatef aspects of BM injury, including myeloerythroid toxicity after clinically relevant exposures to chemotherapeutic drugs and ionizing radiation, as well as BM recovery after drug-induced myelosuppression. [Nat Biomed Eng] Abstract CLINICAL RESEARCHScientists conducted a prospective trial exploring the feasibility of early withdrawal of immunosuppression at day 60 followed by dose escalation of prophylactic donor lymphocyte infusion (pDLI) after alemtuzumab-based, T-cell depleted conditioning for patients with high-risk hematologic malignancies. pDLI were administered at day 75 to day 90 and again in four-eight week intervals with receipt of up to 5 pDLI infusions. [Bone Marrow Transplant] Abstract Researchers compared the immunologic landscape of formalin-fixed paraffin-embedded bone marrow trephine samples from acute myeloid leukemia (AML), chronic myeloid leukemia (AML), and B-cell acute lymphoblastic leukemia patients at diagnosis to controls with 30 immunophenotype markers using multiplex immunohistochemistry and computerized image analysis. They identified distinct immunologic profiles specific for leukemia subtypes and controls enabling accurate classification of AML, chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, and control subjects [Blood Adv] Full Article | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSPersonal Tumor Antigens in Blood Malignancies: Genomics-Directed Identification and Targeting The authors review the advances in systematic identification of minor histocompatibility antigens and neoantigens arising from personal somatic alterations or recurrent driver mutations. These exciting efforts pave the path for the implementation of personalized combinatorial cancer therapy. [J Clin Invest] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSHTG Molecular Diagnostics, Inc. announced it has received notification of validation of European patent number EP 3356554 for its methods for subtyping diffuse large B-cell lymphoma, effective October 2019. HTG was previously granted a patent for this technology in the United States in 2018. [HTG Molecular Diagnostics, Inc.] Press Release Feds Fund Innovative Health Research Happening at DAL, NSHA and IWK Dalhousie University is home to four of the newest recipients of funding from the Government of Canada for their innovative health research. The $1,159,527 in funding is provided by the Canadian Institutes of Health Research Project Grants, which help researchers gather the kind of information they need to make real improvements to clinical practice, health service delivery, and public health policy. [Dalhousie University] Press Release | |
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POLICY NEWSTop Harvard Chemist Charged with Lying about Ties to Chinese Government Program The head of Harvard University’s chemistry department was charged with attempting to conceal his involvement in a Chinese government program to bring scientists to China, an escalation of a crackdown by US authorities on what they perceive as a campaign to steal ideas born in American universities and medical centers. [STAT News] Editorial Iranian Students Denied Entry to US Despite having valid visas to attend universities, more than a dozen would-be graduate students have been detained at the airport and sent back to Iran in recent months. [The Scientist] Editorial Brazil’s Pick of a Creationist to Lead Its Higher Education Agency Rattles Scientists The appointment of a creationism advocate to lead the agency that oversees Brazil’s graduate study programs has scientists there concerned-yet again-about the encroachment of religion on science and education policy. President Jair Bolsonaro’s administration on Saturday January 25th named Benedito Guimarães Aguiar Neto to head the agency, known as CAPES, who previously served as the rector for a private religious school which advocates the teaching and study of intelligent design. [ScienceInsider] Editorial
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EVENTSNEW The Evolving Landscape of Cancer Modeling Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Hereditary and Childhood Tumors (The University of British Columbia) NEW Medical Technologist – Blood Bank (The University of Texas MD Anderson Cancer Center) Scientist – Hematopoietic Stem and Progenitor Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Fellowship – Personalized Cancer Treatments (MGH Cancer Center) Team Leader – Clonal Evolution in Leukemia (Institute of Cancer Research) Faculty Position – Cancer Epidemiology (MD Anderson Cancer Center) Research Fellow – Hematology & Blood Disorders (New York Blood Center) Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine) Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine) Associate/Professor – Hematology & Oncology (UC Davis School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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