Hematopoiesis News 11.06 February 18, 2020 | |
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TOP STORYScientists found that, after mitochondrial activation with replication, HSCs irreversibly remodeled the mitochondrial network and that this network was not repaired after HSC re-entry into quiescence, contrary to hematopoietic progenitors. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)EBF1-Deficient Bone Marrow Stroma Elicits Persistent Changes in HSC Potential Researchers investigated how transcriptional changes in bone marrow mesenchymal stromal cells resulted in long-lasting effects on HSCs. Single-cell analysis of Cxcl12-abundant reticular cells and PDGFRα+Sca1+ cells revealed an extensive cellular heterogeneity but uniform expression of the transcription factor gene Ebf1. [Nat Immunol] Abstract FOXM1 Regulates Leukemia Stem Cell Quiescence and Survival in MLL-Rearranged AML Foxm1 upregulation activated Wnt/β-catenin signaling pathways by directly binding to β-catenin and stabilizing β-catenin protein through inhibiting its degradation, thereby preserving leukemia stem cell (LSC) quiescence, and promoting LSC self-renewal in MLL-rearranged AML. [Nat Commun] Full Article The authors used CRISPR-Cas9 to mimic hereditary persistence of fetal hemoglobin mutations in HBG promoters by generating insertions and deletions, leading to disruption of known and putative repressor binding sites. [Sci Adv] Full Article Researchers investigated hematopoietic cell-specific Hira deletion in mice and showed that it dramatically reduced bone marrow HSCs, resulting in anemia, thrombocytopenia, and lymphocytopenia. In contrast, fetal hematopoiesis was normal in Hira-knockout mice, although fetal HSCs lacked the reconstitution capacity. [Cell Rep] Full Article | Graphical Abstract Investigators deleted a conserved enhancer driving pan-endothelial expression of zebrafish gata2a and showed that Gata2a was required for hemogenic endothelium programming by regulating expression of runx1 and of the second Gata2 orthologue, gata2b. [Commun Biol] Full Article CLINICAL RESEARCHScientists performed a retrospective analysis of data from 74 patients treated with nivolumab. The overall response rate was 58%. Treatment-related adverse events were reported in 56.8% of patients. [Biol Blood Marrow Transplant] Abstract The frequency and clinical importance of hepatitis E virus (HEV) was studied retrospectively in a cohort of 236 Swedish allogeneic HSC transplantation (HSCT) recipients. In blood samples collected at six months after HSCT, HEV RNA was identified in 8/236 patients, and 11/236 patients had detectable anti-HEV IgG and/or IgM, eight of whom were HEV RNA negative. [Bone Marrow Transplant] Abstract Investigators conducted a retrospective study that enrolled 890 allogeneic hematopoietic cell transplantation recipients. The cumulative incidence of Epstein-Barr virus reactivation was 2.9%, 11.7%, 27.3%, and 41.9% for patients with 0, 1, 2, and 3 risk factors, respectively. [Bone Marrow Transplant] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSThe authors review three common treatment modalities used to target BCMA in the treatment of multiple myeloma: bispecific antibody constructs, antibody-drug conjugates, and chimeric antigen receptor-modified T-cell therapy. [Leukemia] Full Article Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSGRAIL, Inc. announced the initiation of the PATHFINDER Study. A prospective, multi-center study, PATHFINDER marks the first time GRAIL’s test results will be returned to healthcare providers and communicated to participants to help guide appropriate diagnostic workup for more than 50 cancer types. [GRAIL, Inc.] Press Release Bristol-Myers Squibb Company announced that the FDA has accepted for Priority Review its BLA for liso-cel, the company’s autologous anti-CD19 chimeric antigen receptor (CAR) T-cell immunotherapy with a defined composition of purified CD8+ and CD4+ CAR T cells for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after at least two prior therapies. [Bristol-Myers Squibb Company] Press Release | |
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POLICY NEWS‘The Disruption Is Enormous.’ Coronavirus Epidemic Snarls Science Worldwide Normal daily life has come to a virtual standstill in large parts of China as a result of the epidemic of COVID-19 – and so has science. Universities across the country remain closed; access to labs is restricted, projects have been mothballed, field work interrupted, and travel severely curtailed. [ScienceInsider] Editorial Harvard, Yale Investigated for Undisclosed Foreign Funding The US Department of Education is investigating Harvard and Yale Universities for allegedly failing to disclose funds from other nations, according to a statement released February 12. First reported by the Wall Street Journal on Wednesday, the investigations are the latest in a series of efforts by the department to crack down on foreign influence in US institutions. [The Scientist] Editorial
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EVENTSNEW European Society for Blood and Marrow Transplantation (EBMT) Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – RNA Modifications, Hematopoiesis and Cancer (Lund University) Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Children’s Hospital) Postdoctoral Researcher – Bioinformatics and Leukemia Stem Cells (The Centre for Genomic Regulation) Postdoctoral Fellow – Hereditary and Childhood Tumors (The University of British Columbia) Postdoctoral Fellowship – Personalized Cancer Treatments (MGH Cancer Center) Postdoctoral Fellow – Erythropoiesis (Mount Sinai School of Medicine) Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine) Associate/Professor – Hematology & Oncology (UC Davis School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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