Hematopoiesis News 11.10 March 17, 2020 | |
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TOP STORYTherapeutic Base Editing of Human Hematopoietic Stem Cells Scientists purified A3A (N57Q)-BE3 base editor for ribonucleoprotein electroporation of human-peripheral-blood-mobilized CD34+ hematopoietic stem and progenitor cells. [Nat Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells Researchers showed that acute immune stimulation with lipopolysaccharide induced only transient changes in HSC abundance, composition, progeny, and gene expression, but persistent alterations in accessibility of specific myeloid lineage enhancers occurred, which increased responsiveness of associated immune genes to secondary stimulation. [Cell Stem Cell] Abstract | Graphical Abstract Dissecting the Early Steps of MLL Induced Leukemogenic Transformation Using a Mouse Model of AML The authors took advantage of cells conditionally blocked at the multipotent hematopoietic progenitor stage to develop a mixed lineage leukemia (MLL)-r model capturing early cellular and molecular consequences of MLL-ENL expression based on a clear clonal relationship between parental and leukemic cells. [Nat Commun] Full Article Chromatin Accessibility Promotes Hematopoietic and Leukemia Stem Cell Activity Investigators report that the chromatin accessibility regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls myeloid differentiation. HMGN1 amplification is associated with increased accessibility, expression, and histone H3K27 acetylation of loci important for HSCs and leukemia, such as HoxA cluster genes. [Nat Commun] Full Article Four Chinese rhesus macaques of SIV chronic infection were given long-term ART, during which peripheral CD34+HSPCs were purified and infected with CCR5-specific CRISPR/Cas9 lentivirus or GFP lentivirus. After non-myeloablative conditioning, the CCR5-modified or GFP-labeled HSPCs were autotransplanted to four recipients and ART was withdrawn following engraftment. [Mol Ther Methods Clin Dev] Abstract | Full Article | Graphical Abstract Scientists showed that niche intrinsic expression of the CXCR4 chemokine receptor critically regulated hematopoietic stem and progenitor cell (HSPC) maintenance during study‐state, and promoted early hematopoietic regeneration after myeloablative irradiation. At steady‐state, chimeric mice with wild‐type HSPC and marrow stroma that lack CXCR4 showed decreased HSPC quiescence, and their repopulation capacity was markedly reduced. [Stem Cells] Abstract Researchers characterized the morpho-phenotypic features and the functional alterations of bone marrow-derived stromal cells (BMSCs) from myelodysplastic syndrome (MDS) patients and in focal adhesion kinase (FAK) knock-downed HS-5 cells. The decreased expression of FAK or its phosphorylated form in BMSCs from low-risk MDS directly correlated with BMSCs’ functional deficiency and was associated with a reduced level of haemoglobin. [Cells] Full Article CLINICAL RESEARCHScientists compared, for acute lymphoblastic leukemia patients in second complete remission, the allogeneic stem cell transplantation outcome from all four possible alternative hematopoietic stem cell sources, namely matched unrelated 10/10, mismatched unrelated 9/10, haploidentical, and cord blood donors. [Bone Marrow Transplant] Abstract A prospectively registered observational study was conducted to assess the significance of allogeneic hematopoietic stem cell transplantation from highly HLA-matched unrelated donors and cord blood on outcomes in adult acute leukemia and myelodysplastic syndrome. [Bone Marrow Transplant] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
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REVIEWSEnhancers and MYC Interplay in Hematopoiesis The authors focus mainly on the enhancers surrounding MYC in the 8q24 locus. That region comprises several enhancers that associate with other transcription factors, transmembrane receptors, and fusion genes composing complex regulatory networks aberrantly expressed in almost all types of hematological malignancies. [J Mol Med] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
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INDUSTRY NEWSForty Seven and Rocket Pharmaceuticals Announce Research Collaboration for Fanconi Anemia Forty Seven, Inc. and Rocket Pharmaceuticals, Inc. announced that they have entered into a research collaboration to pursue clinical proof-of-concept for Forty Seven’s novel antibody-based conditioning regimen, FSI-174 plus magrolimab, with Rocket’s ex vivo lentiviral vector hematopoietic stem cell gene therapy, RP-L102. [Forty Seven, Inc.] Press Release Roche announced that the European Commission has approved Venclyxto® in combination with Gazyvaro® for the treatment of adult patients with previously untreated chronic lymphocytic leukemia. [F. Hoffmann-La Roche Ltd] Press Release | |
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POLICY NEWSJournals, Peer Reviewers Cope with Surge in COVID-19 Publications Academic journals have already taken steps to accelerate the flow of peer-reviewed information by expediting editorial and peer review for coronavirus-related manuscripts and granting them open-access status upon publication. [The Scientist] Editorial Near-Lockdown in the Bay Area ‘Ratchets Up’ Challenges for Local Biotechs and Labs At the stroke of midnight on Tuesday morning, seven counties in the San Francisco Bay Area went into near-lockdown — ushering in a new reality for biopharma companies and biomedical labs. The “shelter in place” order offers significant leeway for medical research. [STAT News] Editorial
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EVENTSNEW European Hematology Association (EHA) Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Scientist – Cancer Immunotherapy (Asgard Therapeutics and Lund University) Postdoctoral Fellow – Hematopoiesis Research (Harvard Medical School) Postdoctoral Researcher – Pediatric Oncology (Universitätsklinikum Carl Gustav Carus) Research Associate – Stem Cell and Gene Therapy Program (Fred Hutchinson Cancer Research Center) Postdoctoral Position – RNA Modifications, Hematopoiesis and Cancer (Lund University) Postdoctoral Fellow Positions – Hematopoietic Stem Cell Biology (Nationwide Children’s Hospital) Postdoctoral Fellow – Hereditary and Childhood Tumors (The University of British Columbia) Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine) Associate/Professor – Hematology & Oncology (UC Davis School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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