Hematopoiesis News 11.18 May 12, 2020 | |
| |
TOP STORYDevelopmental Trajectory of Pre-Hematopoietic Stem Cell Formation from Endothelium To examine the cell and molecular transitions between endothelial, hemogenic endothelial, and intra-arterial cluster (IAC) cells, and the heterogeneity of hematopoietic stem and progenitor cells within IACs, investigators profiled ~37,000 cells from the caudal arteries of embryonic day 9.5 (E9.5) to E11.5 mouse embryos by single-cell RNA sequencing and single-cell assay for transposase-accessible chromatin sequencing. [Blood] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Altered MicroRNA Expression Links IL6 and TNF-Induced Inflammaging with Myeloid Malignancy Researchers identified loss of miR-146a as driving aging-associated inflammation in AML patients. miR-146a expression declined in old wild-type mice, and loss of miR-146a promoted premature HSC aging and inflammation in young miR-146a-null mice, preceding development of aging-associated myeloid malignancy. [Blood] Abstract MBNL1 Regulates Essential Alternative RNA Splicing Patterns in MLL-Rearranged Leukemia Through transcriptomic profiling of experimental systems, scientists showed that in leukemic cells, MBNL1 regulated alternative splicing of several genes including those essential for MLL-rearranged leukemogenesis, such as DOT1L and SETD1A. [Nat Commun] Full Article The ASXL1-G643W Variant Accelerates the Development of CEBPA Mutant Acute Myeloid Leukemia In order to further the understanding of the role of ASXL1 lesions in malignant hematopoiesis, the authors generated a novel knock-in mouse model carrying the most frequent ASXL1 mutation identified in myelodysplastic syndrome patients, p.G643WfsX12. [Haematologica] Abstract The Gut Hormone Receptor GIPR Links Energy Availability to Control of Hematopoiesis The authors assessed the expression of the glucose-dependent insulinotropic polypeptide receptor Gipr in bone marrow lineages and examined functional roles for the GIPR in control of hematopoiesis. [Mol Metab] Abstract | Graphical Abstract Prdm3 and Prdm16 Cooperatively Maintain Hematopoiesis and Clonogenic Potential Scientists showed that combined Mds1-Evi1/Prdm16 deficiency caused bone marrow failure within 15 days, with rapid loss in all progenitor compartments, while the peripheral blood showed progressive reductions in peripheral monocytes and granulocytes. [Exp Hematol] Abstract In vitro megakaryocyte differentiation, proliferation and maturation by romiplostim was less efficient compared to stimulation with murine thrombopoietin. [Exp Hematol] Full Article Biomimetic Aorta-Gonad-Mesonephros-on-a-Chip to Study Human Developmental Hematopoiesis Investigators showed that an Aorta-Gonad-Mesonephros-on-a-chip efficiently derived endothelial-to-hematopoietic transition from human induced pluripotent stem cells compared with regular suspension culture. The presence of mesenchymal stroma and endothelial cells rendered functional HPCs in vitro. [Biomed Microdevices] Abstract Compared to healthy controls, type 1 diabetes patients had significantly lower levels of hematopoietic stem/progenitor cells (HSPCs) and duration of diabetes was inversely correlated with HSPC levels. Significant direct correlations were found between HSPC levels and the coefficient of variation of glucose levels or time in hypoglycaemia, which were stronger in patients with short-term than in those with long-standing diabetes. [J Endocrinol Invest] Abstract CLINICAL RESEARCHTo define the tolerability and outcome of allogeneic hematopoietic stem cell transplant following CAR T-cell therapy, researchers retrospectively reviewed pediatric/young adult patients with relapsed/refractory B-ALL who underwent this treatment. [Bone Marrow Transplant] Abstract Subscribe to one of our other 19 science newsletters such as Cord Blood News & Cell Therapy News. | |
| |
REVIEWSAdvances in CAR T Therapy for Hematologic Malignancies The authors summarize the progress of CAR T therapeutics within malignant hematology thus far and highlight ongoing advances in the field. [Pharmacotherapy] Abstract Visit our reviews page to see a complete list of reviews in the hematopoiesis research field. | |
| |
INDUSTRY NEWSHitachi Chemical Advanced Therapeutics Solutions, LLC and apceth Biopharma GmbH announced that they have expanded their relationship with bluebird bio with long-term development and manufacturing services agreements for clinical and commercial supply for multiple therapies. [Hitachi Chemical Advanced Therapeutics Solutions, LLC (Business Wire, Inc.)] Press Release Gamida Cell Ltd. announced positive topline results from its Phase III clinical study evaluating the safety and efficacy of omidubicel, an investigational advanced cell therapy in development as a potential life-saving treatment option for patients in need of bone marrow transplant. [Gamida Cell Ltd.] Press Release Incysus Therapeutics, Inc. announced that the first patient in a Phase I clinical study titled, “Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide” has been treated at The University of Kansas Cancer Center. [Incysus Therapeutics, Inc. (GlobeNewswire, Inc.)] Press Release | |
| |
POLICY NEWSCoronavirus Shut-Downs Pose Huge Threat to Australian Research Jobs Research in Australia will face drastic cuts in funding and jobs as a consequence of the COVID-19 pandemic and economic shut-downs, according to a report by organizations representing the country’s researchers and academia. [Nature News] Editorial Secretive Jasons to Offer Advice on How to Reopen Academic Labs Shut by Pandemic A group of prominent academic scientists that has been advising the US government on security matters since the Cold War is conducting a quick-turnaround, pro bono study of a new threat to national security-the impact of COVID-19 on academic research. And this time it’s personal. [ScienceInsider] Editorial
| |
EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Hematologic Malignancy (Fred Hutchinson Cancer Research Center) NEW Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital) Postdoctoral Position – Tumor Immunology (University of Maryland) Postdoctoral Position – Leukemia (Josep Carreras Leukaemia Research Institute) Postdoctoral Position – Immunology/Molecular Biology (NIH National Heart, Lung, and Blood Institute) Postdoctoral Associate – Hematopoiesis (The Jackson Laboratory) PhD Position – Leukemic Stem Cells and Metabolism (University of Bern) Scientist – Cancer Immunotherapy (Asgard Therapeutics and Lund University) Postdoctoral Fellow – Hematopoiesis Research (Harvard Medical School) Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine) Associate/Professor – Hematology & Oncology (UC Davis School of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Hematopoiesis News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|