Hematopoiesis News Volume 11.21 | Jun 2 2020

TOP STORY

Yap1-Scribble Polarization Is Required for Hematopoietic Stem Cell Division and Fate

Scientists identified that HSC fitness response to stress depends on Yap1 and Taz. Deletion of Yap1 and Taz induced a loss of HSC quiescence, symmetric self-renewal ability and rendered HSC more vulnerable to serial myeloablative 5-fluorouracil treatment. [Blood] Abstract

(Ranked by impact factor of the journal)

Multispecies RNA Tomography Reveals Regulators of Hematopoietic Stem Cell Birth in the Embryonic Aorta

To explore the molecular characteristics and key components of the aortic microenvironment, where the first HSCs are generated during development, the authors performed genome-wide RNA tomography sequencing on zebrafish, chicken, mouse and human embryos. [Blood] Abstract

Prevalence and Dynamics of Clonal Hematopoiesis Caused by Leukemia-Associated Mutations in Elderly Individuals without Hematologic Disorders

To evaluate the selection of clonal HSCs, bone marrow of two healthy individuals with mutant DNMT3A was transplanted in a humanized mouse model. [Leukemia] Full Article

Putative Regulators for the Continuum of Erythroid Differentiation Revealed by Single-Cell Transcriptome of Human BM and UCB Cells

Scientists dissected the gene expression dynamics from ProE to OrthoE by carrying out scRNA-seq of erythroblasts isolated from human cord blood and bone marrow cells. They subdivided the human erythropoiesis PolyE and OrthoE into early-/late-PolyE and early-/late-OrthoE, respectively. [Proc Natl Acad Sci USA] Abstract

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

Investigators employed a human embryonic stem cell differentiation system capable of forming definitive myeloid progenitor cells to express RUNX1-ETO in an inducible fashion. [Cell Rep] Full Article | Graphical Abstract

Assessment, and Streamlined Preparation of Low Cytotoxicity Lentiviral Vectors for Mobilized Human Hematopoietic Stem Cell Transduction

By employing hematopoietic UT7epo cells cultured in EPO below maximal dosing, scientists first define a sensitive flow cytometric bioassay for critically assessing cytotoxicities (and titers) of lentivirus preparations. [Exp Hematol] Abstract

Inferring Gene Networks in Bone Marrow Hematopoietic Stem Cell-Supporting Stromal Niche Populations

Application of a combination of algorithms, comprising one identifying reliable paths and potential causative relationships in complex systems, revealed gene networks characteristic of the bone marrow stromal HSC-supportive capacity and of defined niche populations of perivascular cells, osteoblasts and mesenchymal stromal cells. [iScience] Abstract | Graphical Abstract

TLR2 and Dectin-1 Signaling in Mouse Hematopoietic Stem and Progenitor Cells Impacts the Ability of the Antigen Presenting Cells They Produce to Activate CD4 T Cells

Researchers evaluated whether treatment of murine bone marrow hematopoietic stem and progenitor cells with a TLR2 or Dectin-1 ligand impacted the antigen presenting capacity of antigen presenting cells derived from them in vitro. [Cells] Full Article

CLINICAL RESEARCH

Complete Remission of Refractory Juvenile Acute Myeloid Leukemia with RUNX1‐PRDM16 in Bloom Syndrome after Hematopoietic Stem Cell Transplantation

Investigators report the genetic basis and disease evolution of a RUNX1-PRDM16 ‐positive acute myeloid leukemia patient with Bloom syndrome. [Br J Haematol] Abstract

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Dysregulated Hematopoietic Stem Cell Behavior in Myeloid Leukemogenesis

The authors review the ways in which leukemic stem cells take advantage of normal HSC properties to promote survival and expansion, thus underlying disease recurrence and resistance to conventional therapies, and they detail the current understanding of leukemic ‘stemness’ regulation. [Nat Rev Cancer] Abstract

Hematopoietic Stem Cell Self-Renewal In Vivo and Ex Vivo

Investigators present the current understanding of HSC self-renewal in vivo and ex vivo, and discuss important advances in ex vivo HSC expansion that are providing new biological insights and offering new therapeutic opportunities. [Nat Rev Genet] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

MacroGenics Announces Registration Study of Flotetuzumab in Patients with Refractory Acute Myeloid Leukemia

MacroGenics, Inc. announced plans for a clinical study intended to support registration in the US of flotetuzumab, an investigational, bispecific CD123 x CD3 DART^® molecule for patients with acute myeloid leukemia who are refractory to induction therapy. [MacroGenics, Inc.] Press Release

Junior Researchers Hit by Coronavirus-Triggered Hiring Freezes

Juan Manuel Vazquez thought he knew where his career would take him after he wrapped up his PhD in genetics at the University of Chicago in Illinois in May. But the COVID-19 pandemic threatened to upend his plans. [Nature News] Editorial

Sputnik Moment or Budget Breaker: How Will the Pandemic Alter Research Funding?

As the pandemic’s economic toll grows around the world, some experts fear it could harm science for decades by putting many thousands of researchers out of work and forcing nations to slash funding as they rebuild societies. [Nature News] Editorial

In light of COVID-19, many conferences are being cancelled or postponed. As such:

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NEW PhD Student Position – Epigenetic Regulation of Hematopoietic Stem Cells (Karolinska Institutet)

NEW PhD Student Position – Leukemic Stem Cell Immune Targeting (Karolinska Institutet)

PhD Studentship – Erythropoiesis (University of Bristol)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Research Fellow – Hematologic Malignancy (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital)

Postdoctoral Position – Tumor Immunology (University of Maryland)

Postdoctoral Position – Leukemia (Josep Carreras Leukaemia Research Institute)

Postdoctoral Position – Immunology/Molecular Biology (NIH National Heart, Lung, and Blood Institute)

Postdoctoral Associate – Hematopoiesis (The Jackson Laboratory)

PhD Position – Leukemic Stem Cells and Metabolism (University of Bern)

Postdoctoral Fellow – Hematopoiesis Research (Harvard Medical School)

Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine)

Associate/Professor – Hematology & Oncology (UC Davis School of Medicine)

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