Hematopoiesis News Volume 11.22 | Jun 9 2020

TOP STORY

RIG-I Regulates Myeloid Differentiation by Promoting TRIM25-Mediated ISGylation

Scientists deciphered the mechanisms promoting myeloid differentiation by RIG-I. They showed that RIG-I could bind TRIM25 mRNA, resulting in enhanced RNA stability and up-regulated protein expression. [Proc Natl Acad Sci USA] Abstract

(Ranked by impact factor of the journal)

Transcriptional Regulatory Network Controlling the Ontogeny of Hematopoietic Stem Cells

Investigators performed RNA-seq and histone mark ChIP-seq to define the transcriptomes and epigenomes of cells representing key developmental stages of HSC ontogeny in mice. [Genes Dev] Abstract

Iron Overload Alters the Energy Metabolism in Patients with Myelodysplastic Syndromes: Results from the Multicenter FISM BIOFER Study

The authors analyzed how the presence of myelodysplastic hematopoiesis, iron overload and chelation impact mitochondrial metabolism. [Sci Rep] Full Article

A Novel Method to Evaluate Prethawing Viability of Cryopreserved CD34⁺ Hematopoietic Stem Cells for Autologous Transplantation

The authors assessed a novel method to measure postfreezing CD34⁺ cell viability, based on small bag samples; results were compared with those obtained on the corresponding mother bags and bag tails. [Transfusion] Abstract

Dynamics of Hematopoiesis Is Disrupted by Impaired Hematopoietic Microenvironment in a Mouse Model of Hemophagocytic Lymphohistiocytosis

Researchers analyzed the dynamics of hematopoiesis in this mouse model of hemophagocytic lymphohistiocytosis. When treated repeatedly with lipopolysaccharide, the numbers of myeloid progenitor cells and B-lymphoid progenitor cells in the bone marrow rapidly decreased after each treatment in both strains. [Ann Hematol] Abstract

ZBTB7A Links Tumor Metabolism to Myeloid Differentiation

Scientists propose that ZBTB7A acts as the link between differentiation and metabolism, two interconnected cellular processes. In particular, ZBTB7A activated or repressed metabolic programs necessary for the differentiation of specific cell linages while controlling key pathways such as Notch signaling. [Exp Hematol] Abstract

KCTD15 Protein Expression in Peripheral Blood and Acute Myeloid Leukemia

Researchers monitored the potassium channel tetramerization domain containing protein family 15 (KCTD15) expression levels in circulating lymphocytes, monocytes, and granulocytes, as well as in leukemia cells. Significant differences in the expression level of KCTD15 were detected in normal lymphocytes, monocytes, and granulocytes. [Diagnostics (Basel)] Full Article

Oral Intake of Lipopolysaccharide Regulates Toll-Like Receptor 4-Dependent Granulopoiesis

Oral intake of highly endotoxic lipopolysaccharide, but not toll-like receptor-antagonistic lipopolysaccharide derived from Rhodobacter sphaeroides, induced hematopoietic stem and progenitor cell fate decisions toward the neutrophil lineage independent of granulocyte-colony stimulating factor. [Exp Biol Med] Abstract

CLINICAL RESEARCH

Allogeneic Hematopoietic Cell Transplantation with Non-Myeloablative Conditioning for Patients with Hematologic Malignancies: Improved Outcomes over Two Decades

For patients with hematologic malignancies who underwent transplantation with non-myeloablative conditioning, outcomes have improved during the past two decades. [Haematologica] Abstract

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CTCF-Mediated Genome Organization and Leukemogenesis

The authors highlight the role of CCCTC-binding factor (CTCF) and its associated protein complexes in three-dimensional genome organization in development and leukemogenesis, as well as the roles of CTCF boundary defined topologically associated domain in transcription regulation. [Leukemia] Abstract

Visit our reviews page to see a complete list of reviews in the hematopoiesis research field.

Aprea Therapeutics Completes Full Enrollment of Phase III Clinical Trial in TP53 Mutant Myelodysplastic Syndromes (MDS)

Aprea Therapeutics, Inc. announced that patient enrollment in its Phase III clinical trial evaluating eprenetapopt with azacitidine for the treatment of front-line TP53 mutant MDS has been completed. [Aprea Therapeutics, Inc.] Press Release

FDA Approves Elixirgen Therapeutics IND Application for Therapy for Telomere Biology Disorders with Bone Marrow Failure

Elixirgen Therapeutics, Inc. received confirmation from the FDA that its Investigational New Drug (IND) application for its lead candidate, EXG4217, was approved on May 23, 2020. [Elixirgen Therapeutics, Inc.] Press Release

As Pandemic Pounds US Universities, Federal Support Helps Their Labs Stay Afloat

This spring, as the coronavirus pandemic shuttered US higher education, many college presidents began to warn of the dire financial impact of a frozen US economy on their institutions. Their mix of revenue sources largely determined how much they might be hurt. [ScienceInsider] Editorial

NIH Grapples with Rush to Claim Billions in Pandemic Research Funds

For the second time in just over 10 years, the National Institutes of Health (NIH) is scrambling to hand out billions of dollars in emergency research funding and scientists are rushing to get a piece of the action—even as some confusion and concerns abound. [ScienceInsider] Editorial

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NEW Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Illinois at Chicago)

PhD Student Position – Epigenetic Regulation of Hematopoietic Stem Cells (Karolinska Institutet)

PhD Student Position – Leukemic Stem Cell Immune Targeting (Karolinska Institutet)

PhD Studentship – Erythropoiesis (University of Bristol)

Postdoctoral Fellowship – Hematopoiesis, Leukemia, and Bone Marrow Failure Syndromes (The University of Texas Southwestern Medical Center)

Postdoctoral Research Fellow – Hematologic Malignancy (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Molecular Hematology (Heidelberg University Hospital)

Postdoctoral Position – Tumor Immunology (University of Maryland)

Postdoctoral Position – Leukemia (Josep Carreras Leukaemia Research Institute)

Postdoctoral Position – Immunology/Molecular Biology (NIH National Heart, Lung, and Blood Institute)

Postdoctoral Associate – Hematopoiesis (The Jackson Laboratory)

PhD Position – Leukemic Stem Cells and Metabolism (University of Bern)

Postdoctoral Fellow – Hematopoiesis Research (Harvard Medical School)

Assistant/Associate Professor – Hematology & Oncology (UC Davis School of Medicine)

Associate/Professor – Hematology & Oncology (UC Davis School of Medicine)

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